Integrated Health Science Facility Core

综合健康科学设施核心

• 批准号: 10600122
• 负责人: Matthew C Cave
• 金额: $ 13.74万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10600122
• 关键词: Adult; Affect; Basic Science; Biological; Biological Markers; Biometry; Charge; Charities; Childhood; Chronic Disease; Clinical; Clinical Research; Clinical Trials; Clinical Trials Unit; Communities; Consent; Consultations; Core Facility; Data; Data Analyses; Development; Disease; Doctor of Medicine; Early Diagnosis; Ensure; Environment; Environmental Health; Evaluation; Fee-for-Service Plans; Goals; Health; Health Sciences; Health Services Accessibility; Human; Human Resources; Human Subject Research; Informatics; Infrastructure; Interdisciplinary Study; Interest Group; Intervention; Knowledge; Life; Measurement; Measures; Metagenomics; Metals; National Institute of Environmental Health Sciences; Nature; Performance; Pharmaceutical Preparations; Physicians; Pilot Projects; Pollution; Population Research; Prevention; Program Evaluation; Proteomics; Public Health Practice; Randomized; Reporting; Research; Research Design; Research Personnel; Research Support; Retrieval; Sampling; Scientist; Services; Technology; Therapeutic Intervention; Time; Training and Education; Translating; Translational Research; Universities; biobank; clinical practice; cohort; community engagement; community involvement; community organizations; cost effective; design; experience; follow-up; human data; human subject; improved; innovation; instrument; instrumentation; interest; lifestyle factors; member; metabolomics; multidisciplinary; patient oriented; programs; recruit; response; sample collection; sex; transcriptomics; volatile organic compound

The overarching objective of the Integrated Health Sciences Facility Core (IHSFC) of the Center for Integrated Environmental Health Sciences (CIEHS) is to translate basic research on pollution and lifestyle factors influencing human health and chronic diseases. The multi-disciplinary IHSFC provides infrastructure facilitating translational human subjects EHS research for the CIEHS, university, and community. The ultimate goal is to improve public health and clinical practice. The IHSFC supports patient-oriented clinical research; group and population-based research; and community engaged/led research. The IHSFC is comprised of two interacting subunits: the Research Administration and Planning Subunit (RAPS) and the Research Implementation Subunit (RIS). The IHSFC interacts with other CIEHS cores and the Research Interest Groups (RIGs) to (i) provide access to state-of-the-art instrumentation and technologies; (ii) increase multidisciplinary collaboration; and (iii) enhance partnerships with community-based organizations. The IHSFC’s first specific aim is to administer the IHSFC and plan translational human subjects EHS research. This aim is performed by RAPS. RAPS provides IHSFC access to CIEHS members, trainees, and the community. RAPS solicits applications for human subjects research; and then reviews, prioritizes and financially subsidizes supported applications. RAPS defines IHSFC research in the context of the NIEHS Translational Research Framework. Community- proposed research ideas are assigned to an appropriate CIEHS member for development and execution. RAPS provides translational research training/education; and tracks and reports performance metrics to the Administrative Core for evaluation. RAPS provides scientific, study design, and community engagement consultation through linkages to the RIGs and other CIEHS cores. These consultations ensure that all IHSFC- supported studies: (i) are rigorously designed and powered; (ii) are consistent with CIEHS’s theme and research interests; and (iii) consider the involvement of community organizations impacting this research. The IHSFC’s second specific aim is to implement IHSFC research. This aim is performed by the RIS. RIS provides human subjects research services and access to state-of-the-art bio-analytic instrumentation and technologies through linkage to the Integrated Toxicomics & Environmental Measurement Facility Core (ITEMFC). In turn, ITEMFC measures exposure and ‘omics-based disease biomarkers. RIS leverages UofL’s adult Clinical Trials Unit (CTU), the Kosair Charities Pediatric Clinical Research Units (KCPCRU), and existing cohorts/biorepositories to obtain human subjects data and biological samples. Next, RIS provides linkage to other CIEHS cores for biomarker measurement, data analysis, and knowledge dissemination. Based on the combination of physician-scientists engaged in EHS research and clinical research units found nowhere else, the IHSFC has the unique capacity to conduct impactful translational EHS research, including biomarker studies and interventional clinical trials.

综合中心综合健康科学设施核心（IHSFC）的总体目标 环境健康科学（CIEHS）是翻译有关污染和生活方式因素的基础研究 影响人类健康和慢性疾病。多学科的IHSFC提供基础架构支持 转化人类主题EHS研究CIEHS，大学和社区。最终目标是 改善公共卫生和临床实践。 IHSFC支持面向患者的临床研究；小组和 基于人群的研究；和社区参与/领导研究。 IHSFC由两个相​​互作用组成 亚基：研究管理和计划亚基（RAP）和研究实施 亚基（RIS）。 IHSFC与其他CIEHS核心和研究兴趣组（钻机）相互作用（i） 提供最先进的仪器和技术； （ii）增加多学科合作； （iii）增强与社区组织的伙伴关系。 IHSFC的第一个具体目的是 管理IHSFC并计划转化人类主题EHS研究。这个目标是通过说唱表演的。 RAPS为CIEHS成员，受训者和社区提供IHSFC访问权限。 RAPS SOLIDS应用程序 人类受试者研究；然后审查，优先级和财务补贴支持的申请。 RAPS在NIEHS翻译研究框架的背景下定义了IHSFC研究。社区- 拟议的研究思想被分配给适当的CIEHS成员进行开发和执行。 RAPS提供翻译研究培训/教育；并跟踪和报告性能指标 评估的行政核心。 RAPS提供科学，研究设计和社区参与 通过与钻机和其他CIEHS内核的联系进行咨询。这些咨询确保所有IHSFC- 支持的研究：（i）经过严格设计和动力； （ii）与CIEHS的主题一致 研究兴趣； （iii）考虑影响这项研究的社区组织的参与。 IHSFC的第二个具体目的是实施IHSFC研究。此目标由RIS执行。 RIS提供 人类受试者的研究服务以及获得最先进的生物分析仪器和技术 通过与综合毒理和环境测量设施核心（ITEMFC）的联系。反过来， ItemFC测量暴露和“基于OMICS的疾病生物标志物”。 RIS利用UOFL的成人临床试验 单位（CTU），Kosair慈善机构儿科临床研究单位（KCPCRU）和现有 队列/生物敏化仪以获取人类受试者数据和生物学样本。接下来，RIS提供了与 其他用于生物标志物测量，数据分析和知识传播的CIEHS核心。基于 从事EHS研究和临床研究单位的身体科学家的结合，没有其他地方 IHSFC具有进行有影响力的翻译EHS研究的独特能力，包括生物标志物 研究和介入的临床试验。