Environmental Liver Disease

环境性肝病

• 批准号: 9762903
• 负责人: Matthew C Cave
• 金额: $ 51.72万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9762903
• 关键词: Academia; Address; Adolescent; Adult; Affect; Animal Model; Area; Cardiovascular Diseases; Cessation of life; Chemical Exposure; Chemicals; Child; Cirrhosis; Collaborations; Data; Development; Diabetes Mellitus; Endocrine; Environment; Environmental Health; Epidemiologist; Exposure to; Fatty Liver; Goals; Government Agencies; Health; Hepatocyte; Industry; Lipids; Liver; Liver diseases; Malignant neoplasm of liver; Medical Societies; Metabolism; Methods; Mission; National Institute of Environmental Health Sciences; Nutrient; Obesity; Physicians; Poison; Policies; Polychlorinated Biphenyls; Population; Practice Guidelines; Reproducibility; Research; Resources; Scientist; Strategic Planning; Time; Training and Education; Transplantation; Vinyl Chloride; Vision; Work; chronic liver disease; diagnostic biomarker; disease registry; environmental chemical; global health; human subject; innovation; next generation; programs; sex

Liver disease is a major global health problem. Fatty liver disease, or excess accumulation of lipids in hepatocytes, affects more than 25% of the worldwide adult population, but children and adolescents may also be affected. Chronic liver disease may progress to cirrhosis and liver cancer resulting in liver-related death or transplantation. Liver disease also impacts the development of diabetes and cardiovascular disease. Liver diseases may be caused or influenced by exposures to environmental chemicals, but this is an understudied area. To address these problems, this project establishes a major integrative and collaborative research program, the Environmental Liver Disease Revolutionizing Innovative, Visionary Environmental Health Research Program (ELD-RIVER). ELD-RIVER will have a transformative impact in the field. The project investigates two broad scientific themes: (i) the impact of endocrine and metabolism disrupting chemicals (EDCs/MDCs) in fatty liver disease, and (ii) other liver diseases (such as liver cancer) associated with chemical exposures. The ELD-RIVER takes a broad integrative scientific approach by investigating relevant chemicals; nutrient:chemical interactions; both animal models and human subjects; and both sexes through state-of-the-art methods including multi-‘omics. EDC/MDC exposures may also impact liver disease through their effects on obesity and diabetes. Thus, obesity and diabetes endpoints will also be evaluated. While the specific projects are expected to evolve over time, the initial work focusses on exposures to polychlorinated biphenyls and vinyl chloride. Both of these chemicals currently rank in the top five in the Agency for Toxic Substances and Disease Registry (ATSDR) Substance Priority List. ELD-RIVER strictly adheres to the principles of scientific rigor and reproducibility and data transparency and availability. ELD-RIVER leverages existing collaborations between multiple organizations including academia, government agencies, industry, and scientific/medical societies. The vision is for ELD-RIVER to become the global hub for environmental liver disease research. To accomplish its translational mission, the program integrates the work of basic scientists, epidemiologists, and physicians. The project will also develop diagnostic biomarkers, new treatments, practice guidelines, and it has the potential to impact policy change. Along the way, unique institutional education/training resources will be utilized so that ELD-RIVER will help produce the next generation of environmental health scientists. The work proposed is relevant to Strategic Plan of the National Institute of Environmental Health Sciences (Themes 1, 2, and 5 and Goals 1, 4, 7, and 8).

肝病是一个主要的全球健康问题。脂肪肝病或超过脂质的积累 肝细胞影响超过25％的全球成年人口，但儿童和青少年也可能 受到影响。慢性肝病可能会发展为肝硬化和肝癌，导致与生命有关的死亡或 移植。肝病还会影响糖尿病和心血管疾病的发展。肝 疾病可能是对环境化学物质的暴露引起或影响的，但这是一种理解 区域。为了解决这些问题，该项目建立了一项主要的综合和协作研究 计划，环境肝脏疾病革命性创新，有远见的环境健康研究 程序（ELD-RIVER）。 ELD-RIVER将对该领域产生变革性的影响。该项目调查了两个广泛的科学 主题：（i）内分泌和代谢破坏化学物质（EDCS/MDC）在脂肪肝病中的影响， （ii）与化学暴露有关的其他肝病（例如肝癌）。 ELD-RIVER需要 通过研究相关化学品的广泛综合科学方法；营养：化学相互作用；两个都 动物模型和人类受试者；以及通过包括多'词的最先进方法的性别。 EDC/MDC暴露也可能通过对肥胖症和糖尿病的影响影响肝病。那，肥胖 还将评估糖尿病终点。 虽然预计特定项目会随着时间的流逝而发展，但最初的工作集中于接触 多氯联苯和氯化乙烯基。目前，这两种化学物质都排名该机构的前五名 用于有毒物质和疾病登记处（ATSDR）物质优先级。 Eld-River严格遵守 科学严谨，可重复性以及数据透明度和可用性的原则。 Eld-River杠杆 多个组织之间的现有合作 科学/医学会。愿景是Eld-River成为环境肝的全球枢纽 疾病研究。为了完成翻译任务，该计划整合了基础科学家的工作， 流行病学家和医生。该项目还将开发诊断生物标志物，新疗法，实践 指南，它有可能影响政策变化。一路上，独特的机构教育/培训 资源将被利用，以便Eld-River将有助于生产下一代环境健康 科学家。提出的工作与国家环境卫生研究所的战略计划有关 科学（主题1、2和5以及进球1、4、7和8）。