Neurodevelopmental Pathways Linking Physical Abuse and Affective Dysregulation

连接身体虐待和情感失调的神经发育途径

基本信息

批准号：
10000191
负责人：
Jamie Lars Hanson
金额：
$ 7.83万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-22 至 2021-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10000191
关键词：
Adolescence Adult Affective Affective Symptoms Amygdaloid structure Anxiety Basic Science Behavior Behavioral Brain Child Childhood Chronic Complement Data Development Developmental Process Diffusion Magnetic Resonance Imaging Dimensions Elements Emotional Emotions Exposure to Foundations Functional Magnetic Resonance Imaging Hippocampus (Brain)Individual Intervention Interview Investigation Life Link Long-Term Effects Longevity Magnetic Resonance Imaging Measures Mediating Memory Mental Depression Mental Health Methods Modeling Mood Disorders Moods Neurobiology Noise Outcome Participant Pathway interactions Patient Self-Report Prefrontal Cortex Psychopathology Public Health Race Records Reporting Risk Risk Factors Risk Marker Sampling Social Work Stress Structure Time Variant Work Youth analytical tool base boys brain circuitry cohort early life adversity epidemiology study experience follow-up insight male maltreatment men multimodality neural circuit neurobehavioral neurobiological mechanism neuroimaging novel physical abuse prevent prospective psychologic racial diversity relating to nervous system research study response social social inequality therapy development

项目摘要

Title Neurodevelopmental Pathways Linking Physical Abuse and Affective Dysregulation Project Summary/Abstract Exposure to physical abuse is a significant risk factor for the development of affective disorders later in life. Though this major public health issue has been well studied and well replicated, much remains unclear about the mechanisms connecting abuse and later depression and anxiety. Past work has primarily relied on self- report measures of maltreatment, which may have significant and confounding biases. Furthermore, previous research studies focused on neurobiological alterations after abuse have only examined one neurobiological marker of risk in the same individuals (such as brain function, but not brain structure). Here, our work leverages existing data collected as part of the Pittsburgh Youth Study, a longitudinal project that followed two cohorts of boys through childhood, adolescence, and into adulthood. At the most recent follow-up, neuroimaging data were collected on a subset of 205 men. For this project, we will focus on corticolimbic circuitry (including the amygdala, portions of the prefrontal cortex, and hippocampus) in relation to physical abuse. This brain circuitry is theorized to be central to processing of emotional and social information, core dysregulated elements in depression and anxiety. Identifying the neurobehavioral bases of these links is crucial to our understanding of the developmental sequelae of abuse, the emergence of depression and anxiety after maltreatment, and the development of intervention strategies aimed at ameliorating the long-term effects of physical abuse. To these ends, this application has two specific aims. First, we will investigate linkages between neurobiology, physical abuse, and symptoms of affective psychopathology. We hypothesize that physical abuse will be related to heightened amygdala functional activity. We additionally predict that abused individuals with heightened amygdala functional activity, as well as reduced amygdala-ventromedial prefrontal cortex connectivity will show the greatest levels of depression and anxiety. Second, we aim to investigate how the chronicity of abuse may impact corticolimbic brain structure and function (again, assessed with multiple methods of MRI). For this aim, we will use latent class-modeling and multivariate MRI analytic tools to examine differences in amygdala and ventromedial prefrontal structure, function, and connectivity. By leveraging rich prospective longitudinal data, we may be able to more accurately characterize foundational principles of brain organization, and more directly connect neurobiology to experiences of abuse. With an alarming amount of children suffering abuse, investigation of these links is important and timely. Our proposed work represents an unprecedented opportunity to understand the neurobiological sequelae of physical abuse. This work can also aid in answering basic science questions, such as how environmental experience influences long-term brain development. Furthermore, this work can powerfully inform our understanding of mood dysregulation in relation to physical abuse.

标题连接身体虐待和情感失调的神经发育途径项目概要/摘要遭受身体虐待是晚年发生情感障碍的一个重要危险因素。尽管这一重大公共卫生问题已得到充分研究和复制，但仍有很多不清楚之处将虐待与后来的抑郁和焦虑联系起来的机制。过去的工作主要依靠自我报告虐待的措施，这些措施可能存在重大且令人困惑的偏见。此外，之前的专注于虐待后神经生物学改变的研究仅检查了一种神经生物学同一个人的风险标记（例如大脑功能，但不是大脑结构）。在这里，我们的工作利用作为匹兹堡青年研究的一部分收集的现有数据，这是一个纵向项目，跟踪了两个一群男孩经历童年、青春期和成年期。在最近的一次随访中，收集了 205 名男性的神经影像数据。对于这个项目，我们将重点关注皮质边缘与身体相关的电路（包括杏仁核、前额皮质的部分和海马体）虐待。从理论上讲，这种大脑回路是处理情感和社会信息的核心，是处理情感和社会信息的核心。抑郁和焦虑中失调的因素。识别这些链接的神经行为基础是对于我们理解虐待的发展后遗症、抑郁症的出现和虐待后的焦虑，以及旨在改善长期焦虑的干预策略的制定身体虐待的影响。为此，该应用程序有两个具体目标。首先，我们将调查神经生物学、身体虐待和情感精神病理学症状之间的联系。我们假设身体虐待与杏仁核功能活动增强有关。我们还预测杏仁核功能活动增强且杏仁核腹内侧功能减少的受虐待个体前额皮质连接将显示出最高程度的抑郁和焦虑。其次，我们的目标是研究长期虐待如何影响皮质边缘的大脑结构和功能（再次评估 MRI 的多种方法）。为此，我们将使用潜在类别建模和多元 MRI 分析检查杏仁核和腹内侧前额叶结构、功能和连接性差异的工具。经过利用丰富的前瞻性纵向数据，我们也许能够更准确地描述基础特征大脑组织原理，更直接地将神经生物学与虐待经历联系起来。与一个遭受虐待的儿童数量惊人，对这些联系进行调查非常重要且及时。我们提出的工作为了解身体虐待的神经生物学后遗症提供了前所未有的机会。这项工作还可以帮助回答基本科学问题，例如环境经验如何影响大脑的长期发育。此外，这项工作可以有力地帮助我们理解与身体虐待相关的情绪失调。