Investigating Links Between Racial and Ethnic Discrimination, Neurobiology, and Internalizing Symptomatology

调查种族和民族歧视、神经生物学和内化症状学之间的联系

基本信息

批准号：
10673000
负责人：
Jamie Lars Hanson
金额：
$ 19.88万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10673000
关键词：
Address Adolescence Adolescent Adrenal Glands Adult African American Amygdaloid structure Anxiety Area Biological Biological Markers Brain Cardiac Childhood Chronic Color Communities Critical Pathways Data Development Discrimination Emotions Exposure to Feeling Female Functional Magnetic Resonance Imaging Goals Hypothalamic structure Image Individual Inflammation Intervention Knowledge Latino Link Longevity Machine Learning Measures Mental Depression Mental Health Meta-Analysis Morbidity - disease rate Neurobiology Neurophysiology - biologic function Participant Pathway interactions Pattern Perception Personal Satisfaction Physiological Physiology Pituitary Gland Prefrontal Cortex Prevention Problem behavior Process Psychopathology Race Reporting Research Rewards Risk Role Sampling Scanning Skin Socioeconomic Status Stress Symptoms Testing Thinking Time Variant Ventral Striatum Work Youth anxiety symptoms biological systems children of color cognitive development cohort depressive symptoms epidemiology study ethnic discrimination executive function experience improved innovation insight interest low socioeconomic status machine learning method mortality neural neural circuit neuroimaging novel prevent psychosocial stressors racial discrimination reward processing sex social symptomatology therapy design tool

项目摘要

Title: Investigating Links Between Racial and Ethnic Discrimination, Neurobiology, and Internalizing Symptomatology Project Summery/Abstract: Racial and ethnic discrimination significantly impact mental health, with these types of negative experiences linked to greater depression and anxiety. While these relations have now been well established in large-scale epidemiological studies, how racial and ethnic discrimination get “under the skin” to create mental health challenges is poorly understood. Suggestive data underscores that racial and ethnic discrimination may be best conceptualized as forms of chronic psychosocial stressors, especially as these experiences are linked with multi-system biological dysregulation. With these physiological changes likely impacting the brain and brain development, it will be critical to understand if racial and ethnic discrimination influence brain development during childhood and adolescence, a developmental transition when the brain is rapidly changing and when mental health problems are increasing. If racial and ethnic discrimination are compromising brain development during this time, such negative experiences may have reverberating repercussions across the lifespan. In the short term, this research will provide insight into how race-related social experiences impact the brain and lead to depression and anxiety, and shed light on underlying mechanisms (i.e., emotion- and reward- processing) that play a role in internalizing problems among youth of Color. In the long term, this knowledge may be critical to the prevention of poor mental health in adolescence and in adulthood among youth of Color. To achieve these goals, this research will leverage, the Adolescent Brain Cognitive Development (ABCD) Study (Total N=11,875; youth of Color N=~4490) and use cutting-edge neuroimaging and machine learning methods to examine if brain functional connectivity is impacted by levels of discrimination. Based on past work in adversity exposed cohorts, we have an a priori interest in the amygdala, ventral striatum, and portions of the prefrontal cortex. We believe that variations in these neural circuits critical for emotion- and reward- processing, as well as executive control, will relate to an increased risk for depression and anxiety; however, we will look for associations between discrimination and functional connectivity across the whole brain. We will also investigate if youth's sex and socioeconomic status moderate the strength of relations between discrimination, neural functioning, and internalizing issues. Pinpointing critical pathways between youth of Color's context and brain development, pathways that are typically overlooked when youth are aggregated, may be crucial for identifying targets for interventions to prevent depression and anxiety. Understanding these mechanisms may also give insight into brain development that may be applied to the prevention of other problem behaviors.

标题：调查种族和民族歧视、神经生物学和内化之间的联系症状学项目总结/摘要：种族和民族歧视会严重影响心理健康，带来这些类型的负面经历与更大的抑郁和焦虑有关，而这些关系现在已经在很大程度上得到了确立。流行病学研究，种族和民族歧视如何“深入皮肤”以创造心理健康人们对这些挑战知之甚少。暗示性数据强调，种族和民族歧视可能是存在的。最好将其概念化为慢性社会心理压力源的形式，特别是当这些经历相互关联时多系统生物失调，这些生理变化可能会影响大脑和大脑发育，了解种族和民族歧视是否影响大脑至关重要儿童期和青春期的发育，大脑快速变化时的发育过渡当心理健康问题日益严重时，如果种族和民族歧视正在损害大脑。在此期间的发展中，此类负面经历可能会在整个社会产生深远的影响从短期来看，这项研究将深入了解与种族相关的社会经历如何影响人的寿命。大脑并导致抑郁和焦虑，并揭示了潜在的机制（即情绪和奖励）从长远来看，这些知识在有色人种青少年的问题内化方面发挥着作用。可能对于预防有色人种青少年青春期和成年期心理健康状况不佳至关重要。为了实现这些目标，本研究将利用青少年大脑认知发展（ABCD）研究（总数 N=11,875；有色青年 N=~4490）并使用尖端神经影像和机器学习根据过去的工作检查大脑功能连接是否受到歧视程度影响的方法。在经历过逆境的人群中，我们对杏仁核、腹侧纹状体和大脑的一部分有先验的兴趣。我们相信这些神经回路的变化对于情绪和奖励至关重要。然而，处理和执行控制会增加抑郁和焦虑的风险；我们将寻找整个大脑的辨别能力和连接功能之间的关联。还调查青少年的性别和社会经济地位是否调节了青少年之间关系的强度歧视、神经功能和内化问题。颜色的背景和大脑发育，当年轻人聚集时通常被忽视的途径，了解这些可能对于确定预防抑郁和焦虑的干预目标至关重要。机制还可以深入了解大脑发育，从而可用于预防其他疾病问题行为。