Integrative Health Sciences

综合健康科学

• 批准号: 7434800
• 负责人: John D Groopman
• 金额: $ 68.03万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7434800
• 关键词: Address; Basic Science; Biological Markers; Certification; Clinical; Clinical Trials; Clinical Trials Data Monitoring Committees; Communities; Community Outreach; Complex; Core Facility; Development; Discipline; Disease; Early Diagnosis; Education and Outreach; Environmental Health; Epidemiology; Ethics; Faculty; Fostering; Goals; Health Sciences; Health Services Accessibility; Human Subject Research; Intervention; Intervention Studies; Investigation; Population; Prevention intervention; Preventive Intervention; Public Health; Public Health Applications Research; Public Health Schools; Purpose; Research; Research Infrastructure; Research Personnel; Schools; Services; Speed; Structure; Support of Research; Technology; Training; Translational Research; Translations; base; burden of illness; design; disorder risk; human subject; improved; instrumentation; interdisciplinary approach; member; research and development

A2. Purpose, Rationale and Objectives The purpose of the Integrated Health Sciences Facility Core (IHSFC) is to facilitate and enhance the speed at which translation of basic research discovery occurs into clinical or public health applications by members of the Johns Hopkins NIEHS Center in Urban Environmental Health. The rationale for incorporating and enhancing the functions of several of our existing facility cores into this new structure is built upon the recognition that addressing the problems of urban environmental health requires multidisciplinary approaches and ever increasing complex technologies. Our past facility core structure often had the unintended consequence of "stove piping" services. Since we are striving to facilitate the tackling of problems across disciplines, we have designed the IHSFC to streamline the ability of Center investigators to do translational research by creating a "one-stop" core that encompasses the services, instrumentation and seed-money necessary to promote linkages to public health. We feel that the IHSFC has taken what we have done well in the past in several facility cores and enhanced these services in a new format that will serve the Center during the next renewal cycle. The specific objectives of this core are: ¿ To provide services and access to instrumentation and technologies that foster integration of basic science into public health research, including epidemiology, prevention and intervention studies. ¿ To support research to improve exposure characterization, early detection of disease risk, biomarker discovery and development of preventive interventions for environmentally related diseases. ¿ To enhance partnerships between researchers and the community that impact on conduct of clinical and public health research through the linkage of the IHSFC with the Community Outreach and Education Core (COEC) in this Center. Translational research always encompasses population or clinical-based investigations that involve human subjects with the goal of reducing disease burden. Irrespective of whether these studies involve etiologic or active interventions, all of these investigations must undergo extensive human subjects review by the Public Health Institutional Review, Submission and Tracking (PHIRST) committee at the Johns Hopkins Bloomberg School of Public Health (http://phirst.jhsph.edu/). All faculty are required to take online training certification about the ethics of human subjects research (at www.citiprogram.org). Furthermore, investigators involved in clinical trials are strongly encouraged to avail themselves of the Center for Clinical Trials (http://cct.jhsph.edu) in the School to provide guidance for ethical research, and the development of data safety and monitoring boards. Thus, the extensive institutional commitment and infrastructure for human subject's research at this School obviates the need for the IHSFC to duplicate these activities.

A2. 目的、理由和目标 综合健康科学设施核心（IHSFC）的目的是促进和加强 基础研究发现转化为临床或公共卫生应用的速度 约翰·霍普金斯大学 NIEHS 城市环境健康中心成员 合并的理由。 并将我们现有的几个设施核心的功能增强到这个新结构的基础上 认识到解决城市环境健康问题需要多学科方法 我们过去的设施核心结构经常出现意想不到的情况。 “炉子管道”服务的后果，因为我们正在努力促进问题的解决。 学科，我们设计了 IHSFC 来简化中心研究人员进行转化的能力 通过创建涵盖服务、仪器和种子资金的“一站式”核心进行研究 我们认为 IHSFC 已经采取了我们在这方面做得很好的做法。 过去在几个设施核心中，并以新的格式增强了这些服务，该格式将在 下一个更新周期。 该核心的具体目标是： ¿提供促进基础科学整合的服务和仪器和技术 进入公共卫生研究，包括流行病学、预防和干预研究。 ¿支持改善暴露特征、疾病风险早期检测、生物标志物的研究 发现和开发与环境相关的疾病的预防性干预措施。 ¿加强研究人员和社区之间的伙伴关系，影响临床和 通过 IHSFC 与社区外展和教育核心的联系开展公共卫生研究 （COEC）在该中心。 转化研究始终涵盖涉及人类的人口或临床研究 无论这些研究是否涉及病因学或疾病负担。 积极干预，所有这些调查都必须经过公众广泛的人类受试者审查 约翰·霍普金斯大学彭博社的卫生机构审查、提交和跟踪 (PHIRST) 委员会 公共卫生学院 (http://phirst.jhsph.edu/) 所有教师都必须参加在线培训认证。 关于人类受试者研究的伦理（参见 www.citiprogram.org）。 强烈鼓励临床试验利用临床试验中心 (http://cct.jhsph.edu) 在学院为伦理研究以及数据安全和监测的发展提供指导 因此，人类受试者研究的广泛机构承诺和基础设施。 学校无需 IHSFC 重复这些活动。