LOW COST MULTI-MODAL ARRAY BASED SMALL ANIMAL SCANNER

基于多模态阵列的低成本小动物扫描仪

• 批准号: 8180293
• 负责人: Jonathan Matthew Cannata
• 金额: $ 49.52万
• 依托单位: WINPROBE CORPORATION
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-05 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8180293
• 关键词: Acoustics; Address; Animal Experimentation; Animals; Biomedical Engineering; Breathing; California; Cancer Detection; Characteristics; Clinical; Clinical Research; Code; Color; Communication; Contrast Media; Costs and Benefits; Custom; Detection; Devices; Diagnostic Neoplasm Staging; Disease; Elements; Environment; Equipment; Frequencies; Functional Imaging; Future; Generations; Goals; Hand; Heart; Housing; Human; Image; Imagery; Intravenous; Investigation; Laboratory Animal Production and Facilities; Language; Lateral; Malignant Neoplasms; Medical; Medical Imaging; Methods; Modality; Modification; Molecular; Morphologic artifacts; Motion; Movement; Mus; Nervous Mouse; Nodule; Optics; Organ; Penetration; Performance; Phase; Phase I Clinical Trials; Polymers; Power Sources; Price; Process; Production; Protocols documentation; Research; Research Design; Research Methodology; Research Personnel; Resolution; Resources; Running; Sales; Sampling; Savings; Scanning; Science; Sentinel Lymph Node; Shapes; Shivering; Signal Transduction; Small Business Innovation Research Grant; Specificity; Speed; Staging; Structure; Surface; System; Technology; Testing; Texas; Thrombus; Thyroid Gland; Time; Transducers; Ultrasonic Transducer; Ultrasonics; Ultrasonography; United States National Institutes of Health; Universities; absorption; acoustic imaging; age discrimination; analog; antibody conjugate; anticancer research; arm; attenuation; austin; base; bean; cancer cell; clinical application; computerized data processing; cost; design; design and construction; digital; high risk; improved; innovation; instrument; instrumentation; lymph nodes; malignant breast neoplasm; meetings; nanoparticle; nanosized; neoplastic cell; plasmonics; professor; programs; public health relevance; theories; tool; tumor; tumor growth; vector

DESCRIPTION (provided by applicant): Low cost high frequency (15, 20 and 25 MHz), and high resolution medical imaging linear array transducers will be designed and constructed for commercial sale under the direction and design of the NIH Resource Center for Ultrasonic Transducer Technology at the University of Southern California. A newly developed high performance ultrasonic scanner, the UltraVision, with the unique feature of having its high speed digital functions entirely within a large Field Programmable Gate Array chip, will be reprogrammed to accommodate the transducers. The UltraVision supports the very advanced features of elastography and optoacoustics and these modes will continue to be functional at these high frequencies. The system will initially be targeted to the morphological and functional imaging of cancer tumors in small animals. The animal studies will be under the direction of the Biomedical Engineering Department of the University of Texas at Austin where Associate Professor Stanislav Emelianov has already guided the UltraVision's design of optoacoustics and elastography. The initial aim is to provide researchers with an accessible tool for cancer research in small animals that will reduce the cost of the science and animal usage. Bringing the new modalities of functional imaging will also increase the specificity of cancer detection and staging. The long term goal is to develop an instrument that will be capable of supporting the emerging field of molecular specific imaging with antibody conjugated nano particles. This new field of optoacoustic imaging of nano particles is very compelling due to their sensitivity, the ability to synthesize their optical spectral absorption, and their non-toxicity. The transducers will be constructed on a 2-2 piezocomposite design known to the investigators Drs. Cannata and Shung and transferred to WinProbe where they will be set up for construction in volumes to be commercialized. The modification to the UltraVision will be largely performed in Very High Speed Integrated Circuit Hardware Description Language, which is not a simple task but it is the only method of accommodating the needs of performing the functions at the required speeds and costs. The acoustic lines will be formed by interlacing and cross-correlation to achieve a very high resolution performance. As the UltraVision Medical Ultrasound System is being commercialized for Breast cancer discrimination and the ageing of thrombi, its price savings from production volume will be shared into the research environment. PUBLIC HEALTH RELEVANCE: This project develops high frequency transducers for a newly developed and uniquely designed medical ultrasonic scanner to image small anatomical structures and to display their functionality. Initially targeted for use in the research of cancer with small animals, its future is seen in the emerging field of functional imaging of the human sentinel lymph nodes with contrast of cancer attaching nano particles. The modifications to the system will be designed to preserve the scanners very low equipment cost.

描述（由申请人提供）：低成本高频（15、20和25 MHz）和高分辨率医学成像线性阵列传感器将在南加州大学NIH超声传感器技术的指导和设计下设计和构建，用于商业销售。新开发的高性能超声扫描仪The Ultravision，其独特功能是将其高速数字功能完全在大型的可编程门阵列芯片中进行重新编程，以适应传感器。 Ultravision支持弹性学和光声的非常高级的特征，这些模式将在这些高频下继续起作用。该系统最初将针对小动物中癌症肿瘤的形态和功能成像。动物研究将在德克萨斯大学奥斯汀分校生物医学工程系的指导下进行，副教授Stanislav Emelianov已经指导了Ultravision的OptoAcoustics和OptoAcoustics和Sulastography的设计。最初的目的是为研究人员提供用于小动物癌症研究的可访问工具，以降低科学和动物使用的成本。带来功能成像的新方式也将增加癌症检测和分期的特异性。长期目标是开发一种能够用抗体共轭纳米颗粒支持分子特异性成像的新兴场。纳米颗粒的光声成像的新领域由于其灵敏度，合成其光谱吸收的能力以及无毒性而非常引人注目。换能器将在研究人员DRS已知的2-2压电材料设计上构造。 Cannata和Shung转移到Winprobe，在那里他们将建立以商业化的批量建设。对紫外线的修改将主要以非常高速的集成电路硬件说明语言进行，这不是一个简单的任务，但这是满足以所需速度和成本执行功能需求的唯一方法。声线将通过插槽和互相关形成，以实现很高的分辨率性能。 随着紫外线超声系统因乳腺癌识别和血栓的衰老而被商业化，因此其生产量的价格将共享到研究环境中。 公共卫生相关性：该项目为新开发和独特设计的医学超声扫描仪开发高频传感器，以对小型解剖结构进行图像并显示其功能。最初是针对小动物研究癌症研究的目标，其未来是在人类前哨淋巴结的功能成像领域中看到的，与附着纳米颗粒的癌症对比。对系统的修改将旨在保护扫描仪的设备成本非常低。