Marietta Community Actively Researching Exposure Study

玛丽埃塔社区积极开展暴露研究

基本信息

批准号：
7429169
负责人：
Erin N Haynes
金额：
$ 58.87万
依托单位：
UNIVERSITY OF CINCINNATI
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-04-01 至 2013-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7429169
关键词：
Address Adult Affect Age Air Air Pollution Alloys Ammonia Animal Feed Animals Apoptosis Appendix Attention Automobile Driving Awareness Biochemical Biological Biological Markers Blood Blood - brain barrier anatomy Brain Breathing Canada Censuses Child Child Development Chinese People Chronic Code Cognitive Collection Communities Complex County Cyclohexane Cyclohexanes Data Databases Deposition Development Differentiation and Growth Distress Dopamine Dose Dust Elements Environmental Exposure Environmental Health Environmental Risk Factor Exhibits Exposure to Eye Burns Fertilizers Fetus Fright Functional disorder Future Gasoline Hair Headache Health Health Policy Home environment Human Industry Infant Knowledge Language Tests Lead Literature Location Long-Term Effects Manganese Manuals Marketing Mathematics Measures Memory Mental disorders Metal exposure Metallic Tastes Metals Methanol Methods Mexico Modeling Moods Motor Muscle Fatigue Myalgia Nail plate Nausea Neighborhoods Neonatal Neuraxis Neurodevelopmental Deficit Neurologic Neurotoxins Newborn Infant Nose Numbers Odors Ohio Oral Oral cavity Outcome Parkinsonian Disorders Particle Size Particulate Pathway interactions Performance Personal Financing Pharyngeal structure Pilot Projects Placenta Plants Policies Pollution Population Predisposition Prevention intervention Process Public Health Quality Control Range Rattus Reaction Time Recruitment Activity Regulation Relative (related person)Reporting Research Research Design Research Project Grants Resources Risk Rural Sampling Scientific Advances and Accomplishments Sensory Smell Perception Sore Throat Source Specimen Steel Study Section Symptoms Taste Perception Testing Time Tooth structure Toxic Environmental Substances Toxicant exposure Training Tremor United States Environmental Protection Agency Universities Visual Washington Water advocacy organizations air cleaner air monitoring base dissemination research drinking water early childhood interest member neurobehavior neurobehavioral neurodevelopment neuropsychiatry neurotoxic neurotoxicity newspaper article particle respiratory response sample collection symposium

Address Adult Affect Age Air Air Pollution Alloys Ammonia Animal Feed Animals Apoptosis Appendix Attention Automobile Driving Awareness Biochemical Biological Biological Markers Blood Blood - brain barrier anatomy Brain Breathing Canada Censuses Child Child Development Chinese People Chronic Code Cognitive Collection Communities Complex County Cyclohexane Cyclohexanes Data Databases Deposition Development Differentiation and Growth Distress Dopamine Dose Dust Elements Environmental Exposure Environmental Health Environmental Risk Factor Exhibits Exposure to Eye Burns Fertilizers Fetus Fright Functional disorder Future Gasoline Hair Headache Health Health Policy Home environment Human Industry Infant Knowledge Language Tests Lead Literature Location Long-Term Effects Manganese Manuals Marketing Mathematics Measures Memory Mental disorders Metal exposure Metallic Tastes Metals Methanol Methods Mexico Modeling Moods Motor Muscle Fatigue Myalgia Nail plate Nausea Neighborhoods Neonatal Neuraxis Neurodevelopmental Deficit Neurologic Neurotoxins Newborn Infant Nose Numbers Odors Ohio Oral Oral cavity Outcome Parkinsonian Disorders Particle Size Particulate Pathway interactions Performance Personal Financing Pharyngeal structure Pilot Projects Placenta Plants Policies Pollution Population Predisposition Prevention intervention Process Public Health Quality Control Range Rattus Reaction Time Recruitment Activity Regulation Relative (related person)Reporting Research Research Design Research Project Grants Resources Risk Rural Sampling Scientific Advances and Accomplishments Sensory Smell Perception Sore Throat Source Specimen Steel Study Section Symptoms Taste Perception Testing Time Tooth structure Toxic Environmental Substances Toxicant exposure Training Tremor United States Environmental Protection Agency Universities Visual Washington Water advocacy organizations air cleaner air monitoring base dissemination research drinking water early childhood interest member neurobehavior neurobehavioral neurodevelopment neuropsychiatry neurotoxic neurotoxicity newspaper article particle respiratory response sample collection symposium

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项目摘要

DESCRIPTION (provided by applicant): Manganese (Mn) is an essential element, yet is neurotoxic in excess. Despite the fact that infants and young children may be at greater risk for Mn neurotoxicity than adults, very few studies have evaluated the effect of chronic Mn exposure on child development. Marietta, Ohio, a rural Appalachian community, has been home to the only metal refinery in the US and Canada for over 50 years. In response, the community formed Neighbors for Clean Air (NCA). The University of Cincinnati (UC) has been asked by NCA to assist them in understanding their exposure and related health effects, if any. For this project, Marietta Community Actively Researching Exposure Study (CARES), the community has defined the research agenda, determining the research questions, objectives, specific aims and identifying resources available within the community to conduct the research. Members of the community will be engaged in all facets of the research project, including environmental sampling, neurobehavioral assessment, project coordination, and collection of biological specimens. The primary objectives of this application are to examine biological indicators of Mn exposure in children and understand the effects of chronic manganese exposure in children. UC will provide training, oversight and expertise in environmental health research, to address the following hypothesis: Exposure to Mn during early childhood is significantly associated with neurodevelopmental deficits in high exposed children ages 7-8 years compared to an age matched low/unexposed group. In order to test the hypothesis, the following community-driven specific aims will be accomplished. Specific Aim 1: Assess environmental Mn exposure within a high Mn exposure community, Marietta, OH and a low Mn exposure community, Cambridge, Ohio. Specific Aim 2: Evaluate comparisons of the neurobehavioral effects in children exposed to Mn in a high Mn exposure community, Marietta, OH and a low Mn exposure community, Cambridge, Ohio. Specific Aim 3: Evaluate comparisons of the neuromotor effects in children exposed to Mn exposure community, Marietta, OH and a low Mn exposure community, Cambridge, Ohio. Given the unique susceptibility of children to toxicant exposure and the opportunity to study Mn exposure in a chronically exposed community, we anticipate this project to significantly impact local and national public health policy related to Mn exposure. Project Narrative Exposure: to manganese (Mn) can result in neurological deficiencies, and here is great potential for global exposure to Mn in the form of MMT, an anti-knock agent to replace lead in gasoline. The Marietta Community Actively Researching Exposure Study (CARES) is a community-based study designed to explore the health effects of long term Mn exposure in children. PUBLIC HEALTH RELEVANCE: Exposure to manganese (Mn) can result in neurological deficiencies, and here is great potential for global exposure to Mn in the form of MMT, an anti-knock agent to replace lead in gasoline. The Marietta Community Actively Researching Exposure Study (CARES) is a community-based study designed to explore the health effects of long term Mn exposure in children.

描述（由申请人提供）：锰（MN）是必不可少的元素，但神经毒性过剩。尽管婴儿和幼儿可能比成年人面临MN神经毒性的风险更大，但很少有研究评估了慢性MN暴露对儿童发育的影响。俄亥俄州玛丽埃塔（Marietta）是一个农村阿巴拉契亚社区，已经成为美国和加拿大唯一的金属炼油厂的所在地，已有50多年的历史了。作为回应，社区形成了清洁空气（NCA）的邻居。 NCA已要求辛辛那提大学（UC）帮助他们了解其暴露及其相关的健康影响（如果有）。对于这个项目，玛丽埃塔社区积极研究暴露研究（CARES），社区定义了研究议程，确定了研究问题，目标，特定的目的，并确定社区内可用的资源来进行研究。社区成员将参与研究项目的所有方面，包括环境抽样，神经行为评估，项目协调和生物标本的收集。该应用的主要目标是检查儿童MN暴露的生物学指标，并了解儿童慢性锰暴露的影响。 UC将在环境健康研究方面提供培训，监督和专业知识，以解决以下假设：与年龄相匹配的低/暴露群体相比，儿童早期在童年时期暴露于MN与7-8岁儿童的神经发育缺陷显着相关。为了检验该假设，将实现以下社区驱动的特定目标。具体目标1：评估俄亥俄州玛丽埃塔（Marietta）的高MN暴露社区中的环境MN暴露，以及俄亥俄州剑桥市的低MN暴露社区。具体目的2：评估在俄亥俄州玛丽埃塔（Marietta）的高MN暴露社区中暴露于MN的儿童中神经行为影响的比较，以及俄亥俄州剑桥市的低MN暴露社区。特定目标3：评估俄亥俄州玛丽埃塔（Marietta）的MN暴露社区的儿童中神经运动效应的比较，以及俄亥俄州剑桥市的低MN暴露社区。鉴于儿童对毒物暴露的独特敏感性以及在长期暴露社区中研究MN暴露的机会，我们预计该项目将显着影响与MN暴露有关的地方和国家公共卫生政策。项目叙述性暴露：锰（MN）可能导致神经缺陷，这是全球暴露于MN的巨大潜力MMT，MMT是一种抗凝剂，替代汽油中的铅。 Marietta社区积极研究暴露研究（CARES）是一项基于社区的研究，旨在探索长期MN暴露在儿童中的健康影响。公共卫生相关性：接触锰（MN）可能导致神经缺陷，这是MMT以MMT的形式全球暴露于MN的巨大潜力，MMT是一种抗凝剂，以取代汽油中的铅。 Marietta社区积极研究暴露研究（CARES）是一项基于社区的研究，旨在探索长期MN暴露在儿童中的健康影响。