Retention, Maintenance and Enhancement of the Communities Actively Researching Exposure Study (CARES)

社区积极研究暴露研究 (CARES) 的保留、维护和加强

• 批准号: 10159288
• 负责人: Erin N Haynes
• 金额: $ 35.77万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-06 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10159288
• 关键词: Adolescent; Adult; Age; Air; Anatomy; Applications Grants; Biological; Biological Markers; Blood; Brain; Caregivers; Chemistry; Chicago; Child; Childhood; Cohort Studies; Collaborations; Communities; Community Developments; Data; Data Management Resources; Data Set; Development; Dust; Environmental Epidemiology; Environmental Exposure; Environmental Health; Environmental Impact; Equipment and supply inventories; Etiology; Evaluation; Exposure to; Funding; Grant; Growth and Development function; Hair; Home; Illinois; Infrastructure; Knowledge; Lab-On-A-Chips; Laboratories; Longevity; Magnetic Resonance Imaging; Maintenance; Manganese; Measurement; Measures; Metals; Methods; Motor; National Institute of Environmental Health Sciences; Neuroanatomy; Neurodevelopmental Deficit; Neuropsychology; Ohio; Outcome; Parents; Participant; Pediatric cohort; Pediatric epidemiology; Physiology; Play; Police; Population; Psychosocial Factor; Reporting; Research; Resources; Role; Saliva; Scientific Advances and Accomplishments; Scientist; Serum; Side; Soil; Structure of nail of toe; Time; Training; United States; Urine; Whole Blood; biobank; cohort; community engaged research; data management; data sharing; deciduous tooth; early childhood; improved; innovation; neurodevelopment; next generation; novel; participant retention; patient engagement; point of care; preservation; primary caregiver; research study; sensor; toxicant; water sampling

PROJECT SUMMARY Manganese (Mn) plays an essential role in normal growth and development The Communities Actively Researching Exposure Study (CARES) was built upon community-engaged research practices. Participants reside in three communities with the nation's highest levels of ambient Mn: Marietta and East Liverpool, Ohio, and Southeast Side Chicago, Illinois. The CARES cohort consists of over 600 children and their primary caregiver, with two time-points (ages 7-9 years and ages 13-17 years) of extensive neurodevelopmental outcomes, biomarkers of exposure, and home environmental measures. The CARES has been supported by multiple NIEHS-funded grants and has been instrumental in the training of next generation community- engaged environmental health scientists for over a decade. The cohort has been instrumental in the development of a lab-on-a-chip sensor for blood metals assessment and is currently exploring the impact of Mn on neuroanatomy, function, chemistry, and physiology through magnetic resonance imaging. Through this project, the CARES research team will be able to conduct the following: Aim 1) Maintain the integrity of the CARES cohort by implementing community-engaged research strategies to improve participant retention; Aim 2) Expand CARES to enhance characterization of critical windows of exposure across the lifespan, and assess the role of caregiver, child, and community-level psychosocial factors on the etiology of toxicant-induced neurodevelopmental deficits; and Aim 3) Maintain and enhance biorepository and data management infrastructure and develop methods to implement data sharing. The CARES is the only cohort poised to investigate ambient exposure to Mn and its relationship to brain function in both a pediatric and adolescent population. The proposed cohort retention, enhancement, and maintenance plans will accelerate and sustain the ability of the CARES cohort to investigate the impact of ambient Mn on neurodevelopmental outcomes, inform federal polices related to ambient exposure to Mn, and serve as a valuable resource for environmental health science trainees and scientists across the globe.

项目摘要 锰（MN）在正常增长和发展中起着至关重要的作用 研究曝光研究（CARES）是建立在社区参与研究实践的基础上的。参与者 居住在三个社区，拥有全国最高水平的环境MN：玛丽埃塔和俄亥俄州东利物浦， 和伊利诺伊州芝加哥东南部。照料队列由600多名儿童及其主要 护理人员，有两个时间点（年龄在7-9岁和13-17岁）的广泛神经发育 结果，暴露的生物标志物和家庭环境措施。照顾得到了 多个NIEHS资助的赠款，并在下一代社区的培训中发挥了作用 - 参与环境健康科学家已有十多年了。该队列在 开发用于血液金属评估的实验室芯片传感器，目前正在探索 通过磁共振成像进行神经解剖学，功能，化学和生理学的MN。通过这个 项目，关怀研究团队将能够进行以下操作：目标1）保持 通过实施社区参与的研究策略来改善参与者的保留率来关心队列；目的 2）扩大护理以增强整个寿命的关键暴露窗口的表征，并评估 照料者，儿童和社区级的心理社会因素在毒物引起的病因上的作用 神经发育缺陷；目标3）维护和增强生物座位和数据管理 基础架构和开发实施数据共享的方法。照顾是唯一准备 研究儿科和青少年的环境暴露于MN及其与大脑功能的关系 人口。拟议的队列保留，增强和维护计划将加速和维持 关怀队列研究环境MN对神经发育结果的影响的能力， 告知与环境暴露于MN有关的联邦政策，并作为环境的宝贵资源 全球健康科学学员和科学家。