Instrumentation for microSPECT and microPET imaging

microSPECT 和 microPET 成像仪器

• 批准号: 7592840
• 负责人: peter L choyke
• 金额: $ 37.34万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7592840
• 关键词: Animal Experimentation; Animals; Area; Basic Science; Beds; Charge; Chemicals; Collimator; Computer Systems Development; Computer software; Coupled; Custom; DAQ; Data Analyses; Development; Devices; Diagnostic; Electronics; Evaluation; Event; Floods; Future; Gamma Cameras; Goals; Growth and Development function; Human; Image; Imaging Device; Imaging technology; Individual; Label; Laboratory Animals; Light; Medical; Mind; Mission; Mus; National Cancer Institute; Nuclear; Optics; Pathway interactions; Photons; Pliability; Positioning Attribute; Positron-Emission Tomography; Purpose; Radioisotopes; Radionuclide Imaging; Research; Research Personnel; Scientist; Side; Speed; Structure; Support Groups; System; Technology; Testing; Time; Tube; Ultrasonography; Validation; Work; base; cancer therapy; computerized data processing; cost; design; detector; human subject; improved; instrumentation; molecular imaging; news; novel; photomultiplier; programs; simulation; single photon emission computed tomography; thallium-doped sodium iodide

The Molecular Imaging Program (MIP) of the National Cancer Institute is charged with the task of developing chemical probes specific to pathways associated with the development, growth and treatment of cancer. Radionuclide-labeled compounds are an important subset of such agents. Successfully developed radionuclide-labeled compounds offer the ultimate prospect of PET, SPECT and planar imaging in human subjects for medical diagnostic and management purposes, and equally powerful applications in basic science when used for probe validation in small laboratory animals. The MIP radionuclide instrumentation group supports this basic science mission by exploring and implementing new radionuclide imaging technologies that improve or advance the state of MIP small animal imaging. Development work carried out by the RIG and its (essential) collaborators is based on the notion of directed exploration where technological opportunities are examined at the research level (panel A, Figure 1) but with a particular systems level goal in mind (panel B, Figure 1). Figure 1. (A): Research areas in imaging system development: (B): current focused systems level development project: dual gamma camera planar projection imaging system for single photon, high-speed dynamic whole body bio-distribution studies in mice. To illustrate this parallelism, work is now underway in the RIG in each of the areas shown in Figure 1A: LaBr3 slab and NaI(Tl) pixelated detector modules and support electronics development (CIT-NIH/RIG); evaluation of a new, modular DAQ system (Thomas Jefferson National Accelerator Facility (JLAB), Newport News, VA/RIG); creation of a high speed data processing interface using both centroid event positioning and advanced Maximum Likelihood (ML) positioning (RIG/CIT); and evaluation of a commercial system (Nuclear Mac) for image display and analysis (RIG/CIT). Each of these sub-system projects are evaluated in light of the current systems level goal of creating a dual planar gamma camera device for imaging mice while at the same time providing information in each technical area for potential use in our next systems level development project. For example, one of the detector modules (M1 or M2 in Figure 1B) will be comprised of a rectangular pixelated NaI(Tl) array coupled to two side-by-side Hamamatsu H8500 position-sensitive photomultiplier tubes (PSPMTs, panel A, Figure2). Initial imaging results obtained with this combination (panel B, Figure 2) required full use of the JLAB DAQ, CIT developed electronics and RIG-developed data processing software for acquisition and analysis of these data. Figure 2. (A): NaI(Tl) detector module and supporting electronics (CIT/RIG); (B): early 511 keV field flood image from this 19 x 42 (43mm x 94 mm) pixel module. Note clear identification of the 2 mm x 2 mm pixels in the gap between the two side-by-side PSPMTs. A custom collimator has been designed for this array where each pixel has its own individual collimator hole. We plan to continue this exploratory work with the goal of turning over the completed dual gamma camera system to MIP scientists in early 2008, followed by a review of accrued technical findings and designation of the next systems level project.

国家癌症研究所的分子成像程序（MIP）负责开发与癌症发育，生长和治疗相关的途径的化学探针。放射性核素标记的化合物是此类药物的重要子集。成功开发的放射性核素标记的化合物为医学诊断和管理目的提供了PET，SPECT和平面成像的最终前景，并且在小型实验室动物中用于探针验证时，在基础科学中同样强大的应用。 MIP放射性核素仪器组通过探索和实施新的放射性核素成像技术来支持这一基础科学任务，从而改善或推进MIP小动物成像状态。钻机及其（基本）合作者进行的开发工作是基于定向探索的概念，在研究级别在研究级别检查了技术机会（面板A，图1），但要牢记特定的系统级别目标（面板B，图1）。 图1。（a）：成像系统开发中的研究领域：（b）：当前的集中系统级别开发项目：针对小鼠单个光子，高速动态全身生物分布研究的双伽马摄像头平面投影成像系统。为了说明这一并行性，现在在图1a所示的每个区域中正在进行工作：Labr3板和NAI（TL）（TL）像素化检测器模块和支持电子开发（CIT-NIH/RIG）； 评估新的模块化DAQ系统（Thomas Jefferson National Accelerator设施（JLAB），Newport News，VA/RIG）；使用Centroid事件定位和高级最大似然（ML）定位（RIG/CIT）创建高速数据处理界面；以及用于图像显示和分析的商业系统（核MAC）的评估（RIG/CIT）。根据当前的系统级别的目标，可以评估这些子系统项目中的每一个，即创建双平面伽马摄像头设备以对小鼠进行成像，同时在每个技术领域提供信息，以在我们的下一个系统级别开发项目中潜在使用。例如，一个检测器模块（图1B中的M1或M2）将由矩形像素化NAI（TL）阵列组成，该阵列耦合到两个并排的Hamamatsu H8500位置敏感的光电兴趣型管（PSPMTS，PSPMTS，图2）。使用此组合获得的初始成像结果（面板B，图2）需要充分使用JLAB DAQ，CIT开发了电子设备和钻机开发的数据处理软件，以获取和分析这些数据。图2。（a）：NAI（TL）检测器模块和支持电子设备（CIT/RIG）； （b）：此19 x 42（43mm x 94毫米）像素模块的511早期kev场洪水图像。请注意，在两个并排PSPMT之间的间隙中，清晰地识别了2 mm x 2 mm像素。为此阵列设计了一个自定义的准直仪，每个像素都有自己的单个准直孔孔。我们计划继续这项探索性工作，目的是在2008年初将完成的双伽马相机系统移交给MIP科学家，然后对下一个系统级项目的应计技术发现和指定进行审查。