EXAMINING THE NEURAL BASES OF AMUSEMENT AND SADNESS

检查娱乐和悲伤的神经基础

• 批准号: 7601873
• 负责人: PHILIPPE R GOLDIN
• 金额: $ 0.58万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7601873
• 关键词: Accounting; Amygdaloid structure; Area; Clip; Computer Retrieval of Information on Scientific Projects Database; Data; Depressed mood; Emotional; Emotions; Film; Functional Magnetic Resonance Imaging; Funding; Grant; Individual; Institution; Left; Light; Lobe; Medial; Methods; National Institute of Mental Health; Nature; Occipital lobe; Participant; Prefrontal Cortex; Rate; Research; Research Personnel; Resources; Source; Stimulus; Thalamic structure; Time; Title; United States National Institutes of Health; Woman; base; emotional experience; experience; neuroimaging; novel; novel strategies; relating to nervous system; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. FULL TITLE: Examining the Neural Bases of Amusement and Sadness: A Comparison of Block Contrast and Dynamic Emotion Intensity Idiographic Regressor Approaches Neuroimaging studies have made substantial progress in elucidating the neural bases of emotion. However, no study to date has taken into account the idiosyncratic, time-varying nature of emotional experience. In the present study, we employed functional magnetic resonance imaging to examine the neural bases of two common emotions: amusement and sadness using both (a) a conventional stimulus-based block contrast approach, and (b) a novel subject-specific, continuous, dynamic emotion intensity rating idiographic regressor approach. Thirteen women twice viewed a set of nine 2-minute amusing, sad, or neutral film clips. On first viewing, participants just watched the films. On second viewing, they made continuous dynamic ratings of amusement and sadness intensity experienced during the first film viewing. Whole-block and idiographic regressor approaches revealed in common that sad films were associated with activations in medial prefrontal cortex (PFC), precuneus, ventral occipital cortex, amygdala and thalamus, and that amusing films were associated predominantly with activations in left PFC and temporal lobes. While the idiographic regressor detected regions similarly identified by the block approach during sad films, it revealed more subcortical and medial PFC areas of activation than the block approach for amusing films. These results suggest a relationship between emotion-specific temporal dynamics and the sensitivity of different data analytic methods for identifying distinct cortical and subcortical regions of activation. These findings shed light on the neural bases of emotion, and suggest a new approach for examining the dynamic aspects of emotional responses that differ so dramatically across individuals. This research was supported by NIMH grant MH58147.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 完整标题：检查娱乐和悲伤的神经基础：块对比和动态情绪强度具体回归方法的比较 神经影像学研究在阐明情绪的神经基础方面取得了实质性进展。然而，迄今为止还没有研究考虑到情感体验的特殊性、随时间变化的性质。在本研究中，我们采用功能磁共振成像来检查两种常见情绪的神经基础：娱乐和悲伤，使用（a）传统的基于刺激的块对比方法，和（b）一种新颖的针对特定主题的连续的、动态情绪强度评级具体回归方法。 13 名女性两次观看了一组 9 个 2 分钟的有趣、悲伤或中性的电影剪辑。第一次观看时，参与者只是观看电影。在第二次观看时，他们对第一次观看电影时经历的娱乐和悲伤强度进行了连续的动态评级。整体块和具体回归方法共同揭示，悲伤电影与内侧前额叶皮层（PFC）、楔前叶、腹侧枕叶皮层、杏仁核和丘脑的激活相关，而有趣的电影主要与左 PFC 和颞叶的激活相关。虽然具体回归器在悲伤电影中检测到了通过块方法类似地识别的区域，但它比有趣电影中的块方法揭示了更多的皮层下和内侧 PFC 激活区域。这些结果表明，情绪特定的时间动态与识别不同皮层和皮层下激活区域的不同数据分析方法的敏感性之间存在关系。这些发现揭示了情绪的神经基础，并提出了一种新方法来检查个体之间差异如此巨大的情绪反应的动态方面。 这项研究得到了 NIMH 拨款 MH58147 的支持。