DNA DESIGNER CRYSTALS

DNA 设计师水晶

• 批准号: 7602336
• 负责人: JENS J BIRKTOFT
• 金额: $ 0.63万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7602336
• 关键词: Binding; Computer Retrieval of Information on Scientific Projects Database; Crystallization; DNA; Funding; Goals; Grant; Institution; Ligands; Memory; Optics; Research; Research Personnel; Resources; Sorting - Cell Movement; Source; Structure; System; United States National Institutes of Health; base; design; macromolecule; nanoelectronics; nanoscale; programs; prototype; scaffold; three dimensional structure

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our research program is designed to utilize new types of macromolecular building blocks, based on branched DNA, as the basis of specific 3D structural designs. The goal of developing the systems is eventually to provide a macromolecular scaffolding, capable of binding, orienting and juxtaposing a variety of molecules, from cellular macromolecules to organic conductors and optical memory components. We propose to determine the structures of 3D periodic arrays, which represent the first designed 3D systems of this sort. The ultimate goal here is to use these arrays to prototype a general form of macromolecular crystallization, in which the DNA components form the host lattice and all crystalline contacts, and macromolecular guests are aligned within the cavities present. This system is likely to enable the initial crystallization of macromolecular species previously intractable to such ordering, and it is also designed to allow analysis of previously crystallized molecules bound to ligands whose presence disrupts their conventional lattices. The ability to produce specific structures on the nanoscale should also enable us to use this system to produce ordered arrangements of so-called cargo hetero-molecules that are attached to the DNA units. Thus, the organization of nanoelectronic components in 3D, leading to smaller and presumably faster computation will likely result from this research

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们的研究计划旨在利用基于分支 DNA 的新型大分子构建模块，作为特定 3D 结构设计的基础。开发该系统的目标最终是提供一种大分子支架，能够结合、定向和并置各种分子，从细胞大分子到有机导体和光学记忆组件。我们建议确定 3D 周期阵列的结构，它代表了此类第一个设计的 3D 系统。这里的最终目标是使用这些阵列来原型化大分子结晶的一般形式，其中 DNA 成分形成主晶格和所有晶体接触，并且大分子客体在存在的空腔内排列。该系统可能能够实现以前难以处理这种排序的大分子物质的初始结晶，并且它还被设计用于分析与配体结合的先前结晶的分子，这些配体的存在破坏了其常规晶格。在纳米尺度上产生特定结构的能力也应该使我们能够使用该系统来产生附着在 DNA 单元上的所谓货物异分子的有序排列。因此，这项研究可能会导致纳米电子元件在 3D 中的组织，从而导致更小且可能更快的计算