Musical Rhythm Sensitivity to Scaffold Social Engagement in Autism Spectrum Disorder

自闭症谱系障碍中音乐节奏对支架社交参与的敏感性

• 批准号: 10016775
• 负责人: Warren Jones
• 金额: $ 56.31万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-11 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10016775
• 关键词: Adult; Affect; Attention; Attenuated; Behavior; Behavior Therapy; Biological; Blinking; Caregivers; Child; Child Development; Child Health; Cognition; Communication; Cues; Data; Development; Disease; Evidence based intervention; Exhibits; Eye; Face; Future; Goals; Health; Human Development; Impairment; Individual; Infant; Infant Behavior; Intervention; Investigation; Measures; Motion; Music; Neurodevelopmental Disorder; Outcome; Periodicity; Process; Randomized; Research; Role; Severities; Social Behavior; Social Development; Social Interaction; Social support; Structure; Systems Biology; Time; Toddler; Training; Unconscious State; arm; autism spectrum disorder; autistic children; base; behavior change; evidence base; experimental study; improved; infancy; insight; millisecond; predicting response; response biomarker; scaffold; social; social communication; social engagement; social interventions; social neuroscience; vocalization

We recently demonstrated that a critical infant adaptive social behavior -- looking into the eyes of an engaging caregiver -- obeys a fundamental biological principle of ‘entrainment’: Infant eye-looking entrains (or becomes time-locked) to the rhythmic social cueing of a caregiver during social musical interactions of infant-directed singing. Equally importantly, caregivers structure their own child-directed behavior to enhance this rhythmic cuing and facilitate the delivery and receipt of meaningful social information. These results inform basic mechanisms of typical social development as well as disruptions in social development in children with ASD. A common and lifelong neurodevelopmental disorder, individuals with ASD exhibit impairments in social and communicative functioning that require specialized support. In pilot data for the current proposal, we observe that toddlers with ASD show attenuated, though present, rhythmic entrainment to predictable child-directed singing. The current project builds upon our findings of rhythmic social entrainment during infancy to advance mechanistic understanding of rhythmic entrainment in social development in typically developing toddlers and those with ASD, as well as propose rhythmic entrainment as an active ingredient of music-based interventions for social communication in toddlers with ASD. In the R61, we first quantify the effects of rhythmic entrainment to child- directed singing in toddlers with and without ASD (R61 Aim 1) and examine predictability as a driver of this entrainment (R61 Aim 2). Successfully establishing rhythmic entrainment during predictable social musical engagement (Go/No-Go criteria) will provide strong evidence of a potential fundamental role of rhythm sensitivity in social entrainment. In the R33, we measure the extent to which individual levels of rhythmic entrainment in ASD are mechanistic predictors of response to music-enhanced and standard evidence-based naturalistic developmental behavioral interventions for ASD (R33 Aim 3). Establishing malleability in social rhythm sensitivity is a crucial step for identifying potential mechanisms of change for future investigations of music-based treatments for functional social communication outcomes in ASD. In alignment with RFA-AT-19-001, Promoting Research on Music and Health, this project will facilitate rigorous studies of child health and development and musical interventions. Through examination of the principles of social entrainment afforded by natural social musical interactions, this research has implications for basic mechanisms of disrupted interpersonal synchrony in ASD, while also identifying potential targets of active engagement for the development of music-based interventions.

我们最近证明了一个关键的婴儿自适应社会行为 - 看着一个引人入胜的眼睛 护理人员 - 遵守“夹带”的基本生物学原理：婴儿眼外观的入口（或变成 时间锁定）在婴儿指导的社交音乐互动中，照顾者的节奏社交提示 歌唱。同样重要的是，护理人员构建了自己的指导行为，以增强这种有节奏的提示 并促进交付和接收有意义的社会信息。这些结果信息基本机制 典型的社会发展以及ASD儿童社会发展的破坏。一个常见和 终身神经发育障碍，ASD暴露在社会和沟通中遭受影响的人 需要专门支持的功能。在当前建议的试点数据中，我们观察到 ASD Show虽然存在，尽管存在，但有节奏的入口，可预测的儿童指导的唱歌。电流 项目基于我们在婴儿期间的节奏社会夹带的发现，以提高机理 了解社会发展中的节奏入口，典型发展幼儿和 ASD，以及建议节奏入口，作为基于音乐的社会干预措施的积极成分 与ASD的幼儿交流。在R61中，我们首先量化了节奏夹带对儿童的影响 指示有和没有ASD的幼儿唱歌（R61 AIM 1）并检查可预测性作为驱动力 盛放（R61 AIM 2）。在可预测的社交音乐期间成功建立节奏 参与（GO/No-Go标准）将提供有力的节奏敏感性潜在基本作用的有力证据 在社会上。在R33中，我们衡量各个节奏含义的程度 ASD是对音乐增强和标准循证自然主义的反应的机械预测指标 ASD的发展行为干预措施（R33 AIM 3）。在社会节奏敏感性方面建立延展性 是确定变革的潜在机制的关键步骤，以便将来调查基于音乐 ASD功能社会沟通成果的治疗方法。在与RFA-AT-19-001保持一致，促进 关于音乐和健康的研究，该项目将促进对儿童健康和发展的严格研究以及 音乐干预措施。通过检查自然社会提供的社会入口原则 音乐互动，这项研究对破坏人际同步的基本机制有影响 在ASD中，同时还确定了积极参与的潜在目标以发展基于音乐 干预措施。