STRUCTURE-FUNCTION STUDIES OF CYSTEINE PROTEASES OF PARASITIC DISEASE AND ALLERG

寄生虫病和过敏症半胱氨酸蛋白酶的结构功能研究

• 批准号: 7597974
• 负责人: LINDA S BRINEN
• 金额: $ 0.26万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7597974
• 关键词: Allergic; Alzheimer' s Disease; Arthritis; Asthma; Bacterial Infections; Biological Process; Chagas Disease; Class; Computer Retrieval of Information on Scientific Projects Database; Cysteine Protease; Disease; Endopeptidases; Enzymes; Eukaryota; Eukaryotic Cell; Funding; Grant; Human; Hypersensitivity; Institution; Life Cycle Stages; Osteoporosis; Papain; Parasitic Diseases; Parasitic infection; Peptide Hydrolases; Play; Protozoa; Pyroglyphidae; Range; Research; Research Personnel; Resolution; Resources; Role; Source; Structure; Therapeutic; Trypanosoma cruzi; United States National Institutes of Health; antigen processing; cancer cell; cruzain; design; inhibitor/antagonist; member; programs; pyroglyphid; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cysteine proteases are present in nearly all groups of eukaryotes and play vital roles in a wide range of biological processes and diseases, including antigen processing, bacterial infection, arthritis, osteoporosis, Alzheimer¿s disease and cancer cell invasion. Several cysteine proteases of the papain superfamily are critical to the life-cycle progression of many pathogenic protozoa and therefore they represent potential targets for selective inhibitor design. It has also been determined that members of this same class of enzyme are required for human allergic and asthmatic response to the common house dust mite. High-resolution structural studies have provided valuable information for the design of anti-parasitic therapeutics that selectively regulate the cysteine protease cruzain, a key enzyme in the lifecycle of T. cruzi, the causative agent of Chagas¿ disease. The studies detailed in this program will expand our understanding and ability to regulate several new protease targets indicated in a variety of parasitic infections as well as proteases of dust mite allergy induced asthma.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以出现在其他 CRISP 条目中 列出的机构是。 对于中心来说，它不一定是研究者的机构。 半胱氨酸蛋白酶几乎存在于所有真核生物中，在多种生物过程和疾病中发挥着至关重要的作用，包括抗原加工、细菌感染、关节炎、骨质疏松症、阿尔茨海默病等。木瓜蛋白酶超家族的几种半胱氨酸蛋白酶对于许多致病性原生动物的生命周期进展至关重要，因此它们代表了选择性抑制剂设计的潜在目标。人类对常见屋尘螨的过敏和哮喘反应需要酶。高分辨率结构研究为选择性调节半胱氨酸蛋白酶 cruzain 的抗寄生虫疗法的设计提供了宝贵的信息。克氏锥虫生命周期中的关键酶，恰加斯病的致病因子¿该计划中详细的研究将扩大我们对调节多种寄生虫感染以及尘螨过敏引起的哮喘的蛋白酶中的几种新蛋白酶靶点的理解和能力。