University of Pennsylvania Patient-derived Xenograft Development and Trials Center

宾夕法尼亚大学患者来源的异种移植开发和试验中心

• 批准号: 10733232
• 负责人: MARTIN CARROLL
• 金额: $ 6.84万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-05 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10733232
• 关键词: Acceleration; Advocate; Award; Awareness; Biostatistics Core; Cancer Patient; Clinic; Clinical Trials; Collaborations; Communication; Communities; Community Outreach; Data Commons; Development; Disabled Persons; Ensure; Goals; Human Resources; Individual; Institution; Leadership; Malignant Neoplasms; Manuscripts; Minority Groups; Outcomes Research; Patients; Pennsylvania; Pilot Projects; Progress Reports; Publications; Research; Research Personnel; Resources; Schedule; Services; Tissue Banks; Tissues; Translational Research; Underrepresented Minority; Universities; Update; Visit; Work; Writing; community engagement; equity, diversity, and inclusion; innovation; lecturer; meetings; patient derived xenograft model; preclinical development; programs; recruit; success; training opportunity; women with disabilities

Summary: The goal of the Administrative Core of the University of Pennsylvania PDX Development and Trials Center is primarily to facilitate innovative translational science that will accelerate the application of new discoveries to the clinic for cancer patients. This will be achieved through a combination of enhancing both the development of unique PDX models at UPENN and through facilitating interaction with the PDXNet. The Administrative Core will be responsible to make sure that the UP-PDTC acts effectively as a research unit of PDXNet. The primary responsibilities of the Administrative Core are to provide scientific leadership, administrative services, and financial oversight, as well as to function as a communication hub for all UP-PDTC-related activities. The Administrative Core will support investigators and personnel in Projects 1-2, the PDX Core, the Pilot Projects and Trans-Network Core, and the Biostatistical Core. The Administrative Core will arrange at least annual meetings of the SAB of the UP-PDTC. Of note, the Administrative Core coordinates all efforts in support of diversity, equity, and inclusion, including ensuring and facilitating wide representation of all minority groups in the tissue banks and PDX models developed by the UP-PDTC. The Administrative Core provides each of these groups with centralized organization and support for their activities, and helps each group stay informed about activities, meetings, opportunities, and other information pertinent to the UP-PDTC. The Administrative Core will be responsible for communication with PDXNet personnel (PDXNet Steering Committee) as well as NCI personnel and will provide support for all collaborations. In particular, the Administrative Core will facilitate interactions between UP-PDTC personnel and the PDXNet Data Commons and Administrative Center. Continuity of support provided by the staff will result in efficient and effective administration for the UP-PDTC.

概括： 宾夕法尼亚大学 PDX 开发和试验中心行政核心的目标是 主要是为了促进创新转化科学，加速新发现的应用 癌症患者的诊所。这将通过加强发展和发展相结合来实现 UPENN 独特的 PDX 模型并通过促进与 PDXNet 的交互。行政部门 Core 将负责确保 UP-PDTC 作为 PDXNet 的研究单位有效运作。这 行政核心的主要职责是提供科学领导、行政服务、 和财务监督，并作为所有 UP-PDTC 相关活动的沟通中心。这 行政核心将为项目 1-2、PDX 核心、试点项目的研究人员和人员提供支持 跨网络核心和生物统计核心。行政核心每年至少安排一次 UP-PDTC 的 SAB 会议。值得注意的是，行政核心协调所有支持的努力 多样性、公平性和包容性，包括确保和促进所有少数群体的广泛代表性 UP-PDTC 开发的组织库和 PDX 模型。管理核心提供以下各项 这些团体的活动得到集中组织和支持，并帮助每个团体随时了解情况 有关 UP-PDTC 的活动、会议、机会和其他信息。行政部门 Core 将负责与 PDXNet 人员（PDXNet 指导委员会）以及 NCI 人员将为所有合作提供支持。特别是，行政核心将促进 UP-PDTC 人员与 PDXNet 数据共享和管理中心之间的交互。 工作人员提供的持续支持将使 UP-PDTC 的管理更加高效和有效。