2022 Sensory Transduction in Microorganisms GRC & GRS

2022年微生物感觉转导GRC

• 批准号: 10374971
• 负责人: Karen M Ottemann
• 金额: $ 0.8万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-11-01 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10374971
• 关键词: Address; Allergic Disease; Antibiotics; Antimicrobial Resistance; Applied Research; Area; Bacteria; Bacteriophages; Basic Science; Behavior; Biochemistry; Biology; Biophysics; Cell physiology; Cells; Cellular biology; Chemicals; Collaborations; Communicable Diseases; Communities; Cryo-electron tomography; Data; Development; Disease; Eating; Environment; Event; Fostering; Goals; Health; Human; Image; Immune System Diseases; Immune system; Institutes; Invaded; Knowledge; Life Style; Macromolecular Complexes; Mammals; Methods; Microbial Biofilms; Microbiology; Microfluidics; Mission; Modeling; Molecular; Molecular Genetics; National Institute of Allergy and Infectious Disease; Output; Participant; Pathogenesis; Pathway interactions; Persons; Plants; Postdoctoral Fellow; Process; Property; Research; Research Personnel; Resolution; Role; Science; Scientist; Sensory; Signal Transduction; Specialist; Structure; System; Systems Biology; Techniques; Time; Tissues; Training; Transcriptional Regulation; Underrepresented Populations; United States National Institutes of Health; Virulence; Virulence Factors; Work; antimicrobial; bacterial genetics; base; career; cell motility; combat; design; educational atmosphere; experimental study; fighting; graduate student; host colonization; host-microbe interactions; innovation; interdisciplinary collaboration; interest; macromolecular assembly; mechanotransduction; meetings; microbial; microbial community; microbiome; microbiota; microorganism; pathogen; pathogenic bacteria; posters; prevent; programs; receptor; response; skills; small molecule; success; supportive environment; symposium; synthetic biology

Project summary The 2022 Gordon Research Conference on Sensory Transduction in Microorganisms to be held in Ventura CA in January 2022 will explore recent advances in understanding signal transduction in bacteria, especially pathogens. Focus will be placed on chemosensory mechanisms and pathways, small molecule intracellular signals (e.g. c-di-GMP), two component systems and the cellular processes they regulate as well as mechanisms of bacterial lifestyle decisions including biofilms, bacterial multicellular behavior and predator-prey interactions. The roles of these systems with respect to pathogenesis, antimicrobial resistance, and synthetic biology will be central themes. An important topic for this conference will be host-microbe interactions. All these critical areas will be addressed through cutting-edge applications of molecular genetics, cell biology, biochemistry, and chemical biology as well as structural, imaging, biophysical, and computational approaches. Data from high-resolution experiments will be paired with modeling to understand and predict the behavior of complex macromolecular assemblies and signaling circuitry. Invited speakers will include both established and early-stage investigators using a wide array of approaches. In addition, short talks will be chosen from the abstracts to give additional early-career scientists a chance to speak, and to round on the program. Participants will benefit from the Conference's open, collegial atmosphere that provides multiple opportunities to engage in scientific discussion, promote scientific rigor, and foster interdisciplinary collaboration. New, innovative efforts will be used to increase participation of scientists from historically under-represented backgrounds, and multiple efforts will be taken to make participants feel welcome and valued. For the fifth time, a Gordon Research Seminar (GRS) for postdocs and graduate students will precede the GRC. The GRS provides a supportive environment for young scientists to present their work, make connections, and receive advice by leaders in the field. The STIM community has long supported junior scientists, and we view the success of the GRS as a necessity to continue on this mission. The GRS will help us not only nurture the development of early stage investigators, but also promote diversity within our community. The GRS will help junior scientists gain the confidence and skills to become full-fledged GRC participants. The well-integrated STIM GRC/GRS will direct established investigators to the most important questions confronting our field and will encourage young scientists to apply their recent training to the exciting new areas of microbiology.

项目摘要 2022年戈登（Gordon）在Ventura CA举行的微生物感官转导研究会议 2022年1月，将探讨了解细菌信号转导的最新进展，尤其是 病原体。重点将放在化学感应机制和途径上，小分子细胞内 信号（例如C-DI-GMP），两个组件系统及其调节的细胞过程以及 细菌生活方式决策的机制，包括生物膜，细菌多细胞行为和捕食者捕集 互动。这些系统在发病机理，抗菌耐药性和合成方面的作用 生物学将是中心主题。本次会议的一个重要主题是主机互动。所有这些 关键领域将通过分子遗传学，细胞生物学， 生物化学和化学生物学以及结构，成像，生物物理和计算方法。 高分辨率实验的数据将与建模配对，以了解和预测 复杂的大分子组件和信号通路。邀请发言人将包括建立和 早期的研究人员使用多种方法。此外，将从 摘要使额外的早期科学家有机会讲话，并可以围绕该计划进行巡回演讲。 参与者将受益于会议的公开氛围，该氛围提供多种机会 进行科学讨论，促进科学严谨和培养跨学科的合作。新的， 创新的努力将用于增加科学家的参与历史不足的人的参与 背景和多项努力将使参与者感到受欢迎和受到重视。第五次 戈登研究研讨会（GRS）针对博士后和研究生将在GRC之前。 GRS 为年轻科学家提供了一个支持环境，以展示他们的工作，建立联系并接收 该领域的领导人的建议。 Stim社区长期以来一直支持初级科学家，我们认为 GRS的成功是继续执行此任务的必要性。 GRS不仅会帮助我们培养 发展早期研究人员，但也促进了我们社区内的多样性。 GRS会有所帮助 初级科学家获得了成熟的GRC参与者的信心和技能。整合的 STIM GRC/GRS将指导既定的调查人员到我们领域面临的最重要问题， 将鼓励年轻科学家将最近的培训应用于微生物学的令人兴奋的新领域。