New Jersey ECHO

新泽西回声

基本信息

批准号：
10745804
负责人：
MARTIN J BLASER
金额：
$ 142.88万
依托单位：
RUTGERS BIOMEDICAL AND HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-01 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10745804
关键词：
Acids Address Age Airway Disease Allergic rhinitis Antibiotics Asian Asthma Basic Science Birth Black race Breast Feeding Cesarean section Child Child Health Childhood Clinical Communities Conceptions County Development Discipline of obstetrics Disease Disparity Drug Exposure Education Ensure Environmental Exposure Ethnic Origin Exposure to Growth Health High Prevalence Hispanic Immigrant Immigrant community Immune Impairment Income Infant Infant Development Infant formula Infection Insurance Intervention Intravenous Knowledge Life Life Cycle Stages Literature Longevity Maternal and Child Health Mediating Medicine Minority Women Modernization Mothers Neonatal New Brunswick New Jersey Outcome Participant Patients Persons Pharmaceutical Preparations Phase Policies Population Heterogeneity Population Study Pregnancy Prospective Studies Prospective cohort Protocols documentation Public Health Race Reporting Research Risk Role Site Skin Structure Time Urbanization Vaginal delivery procedure Woman cohort early childhood epidemiology study ethnic disparity ethnic minority experience feeding health disparity improved infancy marginalized population maternal microbiome microbial microbial signature microbiome microbiome alteration microbiome signature microbiota mouse model neurodevelopment offspring pregnant prenatal public health intervention racial disparity racial minority recruit respiratory health response social determinants sociodemographics socioeconomic disparity

项目摘要

PROJECT SUMMARY/ABSTRACT Early environmental exposures are strongly implicated in the development of later diseases. The early life microbiome provides a developmental context for understanding health and disease across the life course. In the modern era, mothers and children routinely encounter microbiome perturbing exposures including cesarean section, infant formula, and antibiotics during pregnancy and in the child's first year after birth. Compelling basic science and epidemiological research from our group and others shows that perturbation of the pre-conception, prenatal, and early childhood microbiome contributes to adverse health outcomes. These connections are particularly strong for upper and lower airway health. Population-based studies document associations between asthma and early antibiotic exposure, and children with asthma have distinct microbiome signatures from unaffected children. Complementary mouse models show a causal association between perturbed microbiota and airway disease. However, key knowledge gaps remain. First, existing studies lack diversity and are often underpowered to evaluate the extent to which microbiome-perturbing exposures such as medication use, cesarean section, and infant formula underlie racial/ethnic disparities in outcomes such as the higher prevalence of asthma in Black and Hispanic children compared to White children. Second, few studies have examined the microbiome across critical time windows (preconception, pregnancy, delivery, infancy, and early childhood). ECHO provides a unique opportunity to address these gaps and study the developmental role of the early life microbiome in later health in a large, diverse U.S. cohort. We will recruit 500 pregnant people and their resulting offspring from Middlesex County, NJ, one of the most diverse counties in the U.S., into the national ECHO cohort. Our proposed scientific focus is on the early life microbiome and exposure to microbiome-perturbing exposures (cesarean section, infant formula, and medication use) in relation to upper and lower airway health. Our specific aims are to: (1) Characterize social determinants and racial/ethnic disparities in common microbiome-perturbing exposures during critical early life periods in the ECHO-wide cohort and evaluate associations with longitudinal microbiome structures in mothers and children; (2) Estimate associations between microbiome-perturbing exposures and child outcomes, with a focus on upper and lower airway health; (3) Recruit 500 pregnant participants reflecting the unique diversity of Middlesex County, NJ; and (4) (Exploratory) Examine the extent to which maternal microbiome perturbation in the 12 months before conception is associated with adverse upper and lower airway outcomes in children. The addition of NJ contributes unique diversity to the ECHO consortium. In turn, our team's ECHO-wide research at a national scale will yield knowledge that informs clinical and public health interventions that promote a “healthy” microbiome and improve child health.

项目概要/摘要早期的环境暴露与后来疾病的发展密切相关。微生物组为了解整个生命过程中的健康和疾病提供了发展背景。现代，母亲和儿童经常遇到微生物群扰乱的暴露，包括剖腹产怀孕期间和孩子出生后第一年的婴儿配方奶粉和抗生素。我们小组和其他人的科学和流行病学研究表明，受孕前的干扰，产前和儿童早期的微生物组会导致不良的健康结果。基于人群的研究记录了上呼吸道和下呼吸道健康之间的关联。哮喘和早期抗生素暴露有关，患有哮喘的儿童具有独特的微生物组特征未受影响的儿童模型显示出受干扰的微生物群之间存在因果关系。然而，关键的知识差距仍然存在，现有研究缺乏多样性，而且往往缺乏多样性。无力评估微生物群扰乱暴露（例如药物使用）的程度，剖腹产和婴儿配方奶粉导致种族/族裔结果差异，例如较高的患病率其次，很少有研究对黑人和西班牙裔儿童的哮喘发生率进行比较。关键时间窗口（孕前、怀孕、分娩、婴儿期和幼儿期）的微生物组。 ECHO 提供了一个独特的机会来解决这些差距并研究早期生命的发展作用我们将招募 500 名孕妇及其结果，以了解微生物组对以后健康状况的影响。来自新泽西州米德尔塞克斯县（美国最多元化的县之一）的后代进入全国 ECHO 队列。我们提议的科学重点是生命早期微生物组和微生物组扰动暴露（剖腹产、婴儿配方奶粉和药物使用）与上呼吸道和下呼吸道健康的关系。目标是：(1) 描述常见微生物组扰动中的社会决定因素和种族/民族差异在 ECHO 范围的队列中的关键生命早期阶段的暴露，并评估与纵向的关联 (2) 估计微生物组扰动之间的关联（三）招募500名孕妇反映新泽西州米德尔塞克斯县独特多样性的参与者；以及 (4)（探索性）检查其程度受孕前 12 个月内母体微生物群扰动与不良上呼吸道感染相关 NJ 的加入为 ECHO 联盟带来了独特的多样性。反过来，我们团队在全国范围内进行的 ECHO 研究将产生为临床和公众提供信息的知识促进“健康”微生物组并改善儿童健康的健康干预措施。