New Jersey ECHO

新泽西回声

• 批准号: 10745804
• 负责人: MARTIN J BLASER
• 金额: $ 142.88万
• 依托单位: RUTGERS BIOMEDICAL AND HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10745804
• 关键词: Acids; Address; Age; Airway Disease; Allergic rhinitis; Antibiotics; Asian; Asthma; Basic Science; Birth; Black race; Breast Feeding; Cesarean section; Child; Child Health; Childhood; Clinical; Communities; Conceptions; County; Development; Discipline of obstetrics; Disease; Disparity; Drug Exposure; Education; Ensure; Environmental Exposure; Ethnic Origin; Exposure to; Growth; Health; High Prevalence; Hispanic; Immigrant; Immigrant community; Immune; Impairment; Income; Infant; Infant Development; Infant formula; Infection; Insurance; Intervention; Intravenous; Knowledge; Life; Life Cycle Stages; Literature; Longevity; Maternal and Child Health; Mediating; Medicine; Minority Women; Modernization; Mothers; Neonatal; New Brunswick; New Jersey; Outcome; Participant; Patients; Persons; Pharmaceutical Preparations; Phase; Policies; Population Heterogeneity; Population Study; Pregnancy; Prospective Studies; Prospective cohort; Protocols documentation; Public Health; Race; Reporting; Research; Risk; Role; Site; Skin; Structure; Time; Urbanization; Vaginal delivery procedure; Woman; cohort; early childhood; epidemiology study; ethnic disparity; ethnic minority; experience; feeding; health disparity; improved; infancy; marginalized population; maternal microbiome; microbial; microbial signature; microbiome; microbiome alteration; microbiome signature; microbiota; mouse model; neurodevelopment; offspring; pregnant; prenatal; public health intervention; racial disparity; racial minority; recruit; respiratory health; response; social determinants; sociodemographics; socioeconomic disparity; Acids; Address; Age; Airway Disease; Allergic rhinitis; Antibiotics; Asian; Asthma; Basic Science; Birth; Black race; Breast Feeding; Cesarean section; Child; Child Health; Childhood; Clinical; Communities; Conceptions; County; Development; Discipline of obstetrics; Disease; Disparity; Drug Exposure; Education; Ensure; Environmental Exposure; Ethnic Origin; Exposure to; Growth; Health; High Prevalence; Hispanic; Immigrant; Immigrant community; Immune; Impairment; Income; Infant; Infant Development; Infant formula; Infection; Insurance; Intervention; Intravenous; Knowledge; Life; Life Cycle Stages; Literature; Longevity; Maternal and Child Health; Mediating; Medicine; Minority Women; Modernization; Mothers; Neonatal; New Brunswick; New Jersey; Outcome; Participant; Patients; Persons; Pharmaceutical Preparations; Phase; Policies; Population Heterogeneity; Population Study; Pregnancy; Prospective Studies; Prospective cohort; Protocols documentation; Public Health; Race; Reporting; Research; Risk; Role; Site; Skin; Structure; Time; Urbanization; Vaginal delivery procedure; Woman; cohort; early childhood; epidemiology study; ethnic disparity; ethnic minority; experience; feeding; health disparity; improved; infancy; marginalized population; maternal microbiome; microbial; microbial signature; microbiome; microbiome alteration; microbiome signature; microbiota; mouse model; neurodevelopment; offspring; pregnant; prenatal; public health intervention; racial disparity; racial minority; recruit; respiratory health; response; social determinants; sociodemographics; socioeconomic disparity

PROJECT SUMMARY/ABSTRACT Early environmental exposures are strongly implicated in the development of later diseases. The early life microbiome provides a developmental context for understanding health and disease across the life course. In the modern era, mothers and children routinely encounter microbiome perturbing exposures including cesarean section, infant formula, and antibiotics during pregnancy and in the child's first year after birth. Compelling basic science and epidemiological research from our group and others shows that perturbation of the pre-conception, prenatal, and early childhood microbiome contributes to adverse health outcomes. These connections are particularly strong for upper and lower airway health. Population-based studies document associations between asthma and early antibiotic exposure, and children with asthma have distinct microbiome signatures from unaffected children. Complementary mouse models show a causal association between perturbed microbiota and airway disease. However, key knowledge gaps remain. First, existing studies lack diversity and are often underpowered to evaluate the extent to which microbiome-perturbing exposures such as medication use, cesarean section, and infant formula underlie racial/ethnic disparities in outcomes such as the higher prevalence of asthma in Black and Hispanic children compared to White children. Second, few studies have examined the microbiome across critical time windows (preconception, pregnancy, delivery, infancy, and early childhood). ECHO provides a unique opportunity to address these gaps and study the developmental role of the early life microbiome in later health in a large, diverse U.S. cohort. We will recruit 500 pregnant people and their resulting offspring from Middlesex County, NJ, one of the most diverse counties in the U.S., into the national ECHO cohort. Our proposed scientific focus is on the early life microbiome and exposure to microbiome-perturbing exposures (cesarean section, infant formula, and medication use) in relation to upper and lower airway health. Our specific aims are to: (1) Characterize social determinants and racial/ethnic disparities in common microbiome-perturbing exposures during critical early life periods in the ECHO-wide cohort and evaluate associations with longitudinal microbiome structures in mothers and children; (2) Estimate associations between microbiome-perturbing exposures and child outcomes, with a focus on upper and lower airway health; (3) Recruit 500 pregnant participants reflecting the unique diversity of Middlesex County, NJ; and (4) (Exploratory) Examine the extent to which maternal microbiome perturbation in the 12 months before conception is associated with adverse upper and lower airway outcomes in children. The addition of NJ contributes unique diversity to the ECHO consortium. In turn, our team's ECHO-wide research at a national scale will yield knowledge that informs clinical and public health interventions that promote a “healthy” microbiome and improve child health.

项目摘要/摘要 早期的环境暴露与后来的疾病的发展有关。早期生活 微生物组为了解整个生命过程中的健康和疾病提供了发展环境。 现代时代，母亲和孩子通常会遇到微生物组的扰动暴露，包括剖宫产 部分，婴儿配方奶粉和抗生素在怀孕期间以及孩子出生后的第一年。引人注目的基本 我们小组和其他人的科学和流行病学研究表明，召开前的扰动， 产前和幼儿微生物组会导致不良健康结果。这些连接是 对于上和下气道健康特别强。基于人群的研究记录了关联 哮喘和早期抗生素暴露，患有哮喘的儿童具有不同的微生物组特征 未受影响的孩子。互补的小鼠模型显示出扰动的微生物群之间的因果关系 和气道疾病。但是，关键知识差距仍然存在。首先，现有研究缺乏多样性，通常是 无法评估微生物组扰动的暴露（例如使用药物）的程度， 剖宫产部分和婴儿公式是种族/族裔分布的基础，例如较高的患病率 与白人儿童相比，黑人和西班牙裔儿童的哮喘。其次，很少有研究检查 关键时间窗口的微生物组（孕妇，怀孕，分娩，婴儿期和幼儿期）。 Echo提供了一个独特的机会来解决这些差距并研究早期生活的发展作用 以后的卫生中的微生物组在一个大型的美国队列中。我们将招募500名孕妇及其由此产生的 来自新泽西州米德尔塞克斯县的后代是美国最多样化的县之一，进入了国家回声队列。 我们提出的科学重点是早期生活微生物组和暴露于微生物组扰动暴露 （剖宫产部分，婴儿配方和用药）与上下气道健康有关。我们的具体 目的是：（1）表征社会决定者和种族/种族差异 在回声范围的队列中的关键早期生命期间的暴露并评估与纵向的关联 母亲和儿童的微生物组结构； （2）微生物组扰动之间的估计关联 暴露和儿童成果，重点是上下气道健康； （3）招募500名怀孕 参与者反映了新泽西州米德尔塞克斯县的独特多样性； （4）（探索性）检查 在概念前的12个月内，哪个微生物组扰动与不良上部有关 和儿童的气道结局降低。新泽西州的增加为回声财团提供了独特的多样性。 反过来，我们团队在全国范围内的回声整个研究将产生知识，以告知临床和公众 促进“健康”微生物组并改善儿童健康的健康干预措施。