Visible Light Photocatalysis

可见光光催化

• 批准号: 10380452
• 负责人: TEHSHIK P YOON
• 金额: $ 3.76万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-12-01 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10380452
• 关键词: Award; Behavior; Biological; Biology; Biomedical Research; Chemicals; Complex; Copper; Equipment; Generations; Grant; Heart; Life; Light; Methods; Modernization; Molecular Medicine; Molecular Structure; Oxidants; Parents; Pharmaceutical Preparations; Photochemistry; Property; Reaction; Reagent; Request for Proposals; Research; Savings; Structure; System; Techniques; Technology; Visible Radiation; biomedical scientist; catalyst; chemical synthesis; drug discovery; frontier; functional group; irradiation; next generation; novel therapeutics; scaffold; stereochemistry

PROJECT SUMMARY/ABSTRACT Photochemical synthesis represents an exciting frontier for drug discovery and for biomedical research. The ability of small, structurally complex organic molecules to interact with biomolecules and perturb their behavior is at the heart of modern molecular medicine and chemical biology. The discovery of new drugs and biological probes with new properties, therefore, relies critically upon the synthesis of new molecules with unprecedented structures. Photochemistry has long been an underdeveloped technique in chemical synthesis, in part because the irradiation of organic molecules with light results in the generation of highly reactive, high-energy species that can react indiscriminately and unproductively. We are investigating the ways in which addition of various reagents to photochemical reactions can control these photogenerated intermediates in diverse ways. In this proposal, we describe two Specific Aims to study how these reagents can result in powerful new bond forming methods. Aim 1. We are exploring the ability of chiral catalysts to control the stereochemistry of photochemical reactions. Aim 2. We are exploring the ability of copper oxidants to enable the installation of functional groups onto simple unfunctionalized organic scaffolds. These methods enable chemical transformations that cannot otherwise be accomplished using conventional, non-photochemical technologies. Thus, we expect that the results of our research will have significant impacts both in fundamental academic chemical research and on the ability of biomedical scientists to synthesize and discover the next generation of life-saving drugs.

项目摘要/摘要 光化学合成代表了药物发现和生物医学研究的令人兴奋的前沿。这 小，结构复杂的有机分子与生物分子相互作用并扰动其能力 行为是现代分子医学和化学生物学的核心。发现新药 因此，具有新特性的生物探针依赖于新分子的合成 具有前所未有的结构。长期以来，光化学一直是化学欠发达的技术 合成，部分是因为有机分子具有光的照射导致高度产生 反应性的高能物种，可以不加区分和非生产力做出反应。 我们正在研究如何在光化学反应中添加各种试剂的方式 这些光生的中间体以不同的方式。在此提案中，我们描述了两个具体目标 研究这些试剂如何导致强大的新键形成方法。 目标1。我们正在探索手性催化剂控制光化学立体化学的能力 反应。 AIM 2。我们正在探索铜氧化剂使官能团在 简单不官能化的有机脚手架。 这些方法实现了无法使用否则可以使用的化学转化 常规的非光化学技术。因此，我们期望我们的研究结果将有 基本学术化学研究和生物医学能力都有重大影响 科学家综合并发现下一代挽救生命的药物。