SYNTHETIC PHOTOCHEMISTRY

合成光化学

基本信息

批准号：
10330629
负责人：
TEHSHIK P YOON
金额：
$ 22.27万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-01-01 至 2026-12-31
项目状态：
未结题

项目摘要

PROJECT SUMMARY/ABSTRACT Synthetic photochemistry is a powerful tool for biomedical research. The small-molecule therapeutics that constitute the core of modern molecular medicine occupy a relatively narrow segment of chemical diversity space. Photochemistry offers a new capability that can expand the range of chemical structures that can be investigated for their biological activity and their potential as new life-saving drugs. Specifically, reactions that are driven by light can use the energy of a photon to produce highly reactive intermediates that react in ways that are not accessible by other means. Our group's research focuses on the discovery of reaction methods that can control the outcomes of photochemical processes in predictable ways. We have a long-standing interest in the development of mechanistically novel catalytic processes that are directly applicable to the synthesis of complex bioactive compounds. We are also interested in the use of external stimuli that can control or divert the intrinsic reactivity of open-shelled photogenerated intermediates towards desirable synthetic goals. Finally, we are deeply committed to elucidating the mechanisms by which photochemical transformations occur. The next phase of our research will continue to investigate these broad themes. We propose investigations into new strategies for controlling the stereochemistry of diverse photochemical reactions. We will study a new approach towards the generation of carbocationic intermediates from photoredox activation. Finally, we will develop a new class of photoreactions that take advantage of the direct photochemistry of base metal coordination complexes. These studies will result in new, generalizable strategies for the controlled photochemical synthesis of complex organic molecules.

项目概要/摘要合成光化学是生物医学研究的强大工具。小分子疗法构成现代分子医学核心的化学多样性占据相对狭窄的部分空间。光化学提供了一种新功能，可以扩展化学结构的范围研究了它们的生物活性及其作为新救生药物的潜力。具体来说，反应由光驱动的可以利用光子的能量产生高反应性中间体，这些中间体在通过其他方式无法访问的方式。我们小组的研究重点是发现可以控制结果的反应方法以可预测的方式进行光化学过程。我们对以下领域的发展有着长期的兴趣机械新颖的催化过程可直接应用于复杂生物活性物质的合成化合物。我们还对使用可以控制或转移内在的外部刺激感兴趣。开壳光生中间体对理想合成目标的反应性。最后，我们是坚定致力于阐明光化学转化发生的机制。我们研究的下一阶段将继续调查这些广泛的主题。我们建议进行调查成控制不同光化学反应立体化学的新策略。我们将研究一个通过光氧化还原活化生成碳阳离子中间体的新方法。最后，我们将开发一类利用贱金属直接光化学的新型光反应协调配合物。这些研究将为受控光化学合成提供新的、可推广的策略。复杂的有机分子。