2022 Drug Carriers in Medicine and Biology GRC/GRS

2022年医学和生物学药物载体GRC/GRS

基本信息

批准号：
10378904
负责人：
Suzie H. Pun
金额：
$ 1万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-18 至 2022-09-17
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10378904
关键词：
Address Area Basic Science Biodistribution Biological Biology Blood - brain barrier anatomy Blood Vessels Cells Chemistry Clinic Clinical Communities Development Discipline Disease Drug Carriers Drug Delivery Systems Drug Design Drug Formulations Drug Kinetics Engineering Environment Epithelial Faculty Future Goals Hour Immune system Industrialization Industry Institution Knowledge Laboratory Research Learning Lung Mediating Medical Medicine Modern Medicine Molecular Nature Nucleic Acids Oncology Organic Chemistry Pharmaceutical Preparations Pharmacologic Substance Physics Physiological Physiology Postdoctoral Fellow Proteins Research Research Personnel Science Seasons Site Solubility Students System Therapeutic Thinking Time Translations Woman Work base career clinical application design diversity and inclusion engineering design extracellular graduate student innovation insight interdisciplinary approach laboratory development medical specialties meetings multidisciplinary new technology next generation novel strategies novel therapeutics patient oriented posters skills small molecule success symposium

项目摘要

Project Summary The delivery of small molecules, proteins and biologic drugs, nucleic acids, and other molecular therapies relies to the site of the disease-causing target within the body is highly dependent on the ability to manage solubility, stability, biodistribution, and pharmacokinetics of the drug. The Drug Carriers for Medicine and Biology Gordon Research Conference (GRC) and its accompanying Gordon Research Seminar (GRS) provide key platforms for discussion and dissemination of critical developments in the design of drug delivery systems to meet the many unique challenges of this field. Addressing these issues requires an interdisciplinary approach that engages researchers in basic biology and physiology, chemistry, and physics that inform design as well as engineering and clinical perspectives. The GRC provides a unique environment that successfully brings these groups together to discuss and debate fundamental questions about delivery and to share new innovations in the field. The specific aims of this GRC/GRS are: 1) to provide a forum for discussion of the key barriers to delivery and physiological understanding to inform carrier design, 2) to facilitate discussion of delivery systems in an intellectually and culturally diverse, multidisciplinary environment, with input from engineering, physiological, regulatory, and translational perspectives, 3) to enable presentation and discussion of new innovations and cutting-edge research in the drug delivery field, and 4) to create opportunities for young faculty and other early investigators in the field to present their work and to build critical relationships and partnerships for professional advancement. The subtitle for the 2022 GRC is Drug Carriers for Medicine and Biology: “Enabling new therapies through drug carrier design”. Areas of focus in the seminar include new materials for drug delivery, drug carriers in oncology, cell-mediated drug delivery, intracellular delivery of biologics, biological carriers, advances toward translation and carrier interactions with the immune system. The GRS that takes place prior to the GRC enables graduate students and postdoctoral associates to examine the field and address important questions from their own perspectives as early investigators who are thinking toward the future of the field. Speakers will be selected from among research trainees across a broad range of institutions and disciplines. The 2022 GRS theme, which is “Exploring size- based delivery strategies for biologics and novel drug cargos,” will provide a forum for discussion that connects ongoing laboratory research and the kinds of issues that might ultimately determine translational success. The GRS will also feature a plenary speaker who will provide a deep perspective on this question and discussion leaders chosen from among leaders in the field who can provide background and perspective during the discussions.

项目概要小分子、蛋白质和生物药物、核酸和其他分子疗法的输送依赖于体内致病靶标的位置高度依赖于控制溶解度的能力，药物的稳定性、生物分布和药代动力学戈登。研究会议（GRC）及其伴随的戈登研究研讨会（GRS）提供了关键平台讨论和传播药物输送系统设计的关键进展，以满足解决该领域的许多独特挑战需要采取跨学科的方法。吸引基础生物学、生理学、化学和物理学的研究人员参与，为设计和设计提供信息 GRC 提供了一个成功实现这些的独特环境。小组聚集在一起讨论和辩论有关交付的基本问题并分享新的创新该 GRC/GRS 的具体目标是： 1) 提供一个讨论主要障碍的论坛。传递和生理理解，为载体设计提供信息，2) 促进讨论在智力和文化多元化、多学科环境中提供系统，并提供输入从工程、生理、监管和翻译角度，3) 实现演示并讨论药物输送领域的新创新和前沿研究，以及4）创建为该领域的年轻教师和其他早期研究人员提供展示其工作并展示其成果的机会建立重要的关系和伙伴关系以促进职业发展 2022 年 GRC 的副标题。是医学和生物学的药物载体：“通过药物载体设计实现新疗法”。研讨会包括药物输送新材料、肿瘤学药物载体、细胞介导的药物输送、生物制品的细胞内递送、生物载体、翻译和载体相互作用的进展在 GRC 之前进行的 GRS 能够帮助研究生和博士后。员工尽早从自己的角度审视该领域并解决重要问题正在思考该领域未来的研究人员将从研究中选出。 2022 年 GRS 的主题是“探索规模-” 基于生物制品和新型药物货物的交付策略，”将提供一个讨论论坛，将正在进行的实验室研究以及可能最终决定转化成功的各种问题。 GRS 还将邀请一位全体会议发言人就这一问题和讨论提供深入的视角从该领域的领导者中选出的领导者可以在会议期间提供背景和观点讨论。