Multiuser Advanced Confocal Microscope

多用户高级共焦显微镜

• 批准号: 9791445
• 负责人: Zhi Q. Yao
• 金额: --
• 依托单位: JAMES H QUILLEN VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2019-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9791445
• 关键词: Address; Advisory Committees; Basic Science; Cell Communication; Cells; Charge; Clinical; Clinical Sciences; Communicable Diseases; Confocal Microscopy; Contract Services; Core Facility; Data Analyses; Data Quality; Fees; Funding; Grant; HIV/HCV; Health; Home environment; Hour; Hybrids; Image; Imaging Techniques; Imaging technology; Immune; Immune System Diseases; Immunologics; Lasers; Maintenance; Manuals; Medical center; Medicine; Microscope; Minor; Noise; Optics; Population; Radial; Research; Research Personnel; Resolution; Sampling; Scanning; Scientist; Signal Transduction; Speed; Supervision; System; Technology; Time; Tissues; Translational Research; Universities; Veterans; base; chronic infection; cohort; college; confocal imaging; cost; data submission; detector; experience; experimental study; improved; in situ imaging; instrument; live cell imaging; programs; quantitative imaging; response; software systems; square foot; tissue culture; vaccine response

Abstract This request is for a Leica SP8 Confocal Microscope which will function as a multiuser instrument in a core facility at the Mountain Home Medical Center. The system will significantly enhance the research of major users who are conducting VA funded research and multiple minor users. While this microscope will primarily be used for VA funded research, instrument time will also be provided to new investigators and investigators seeking to obtain preliminary data for submission of VA grants. The Mountain Home VA Medical Center currently has no confocal microscope, and currently relies upon a fee-based instrument at the adjacent university. While that microscope continues to be used extensively by the investigators participating in this application, the VA researchers are not a priority for instrument use and the charges for its use are steep. Confocal technology has advanced dramatically in the last several years and the research questions that we are currently asking require that we employ state-of- the-art imaging techniques that are not available on our current instrument. We are clearly at the point where our current fee-based instrument does not meet the needs of VA funded investigators, with multiple VA Merit- and DOD-funded studies relying on confocal microscopy. There are no other confocal microscopes for use within a 200 mile radius of our VA. Therefore, this application addresses a significant research need. The Mountain Home VA has a strong institutional commitment to the acquisition and maintenance of the confocal microscope. A 500 sq. ft. room, that is appropriately outfitted to house the instrument, has been allocated. Provisions have been made to underwrite the service contract once the initial warranty period has expired. An advisory committee has been established. A doctoral level scientist, with experience in confocal microscopy, will supervise the facility with the assistance of an experienced research technician. This instrument will significantly improve the research efforts at Mountain Home VA aimed at improving veterans' health.

抽象的 此请求是对Leica SP8共聚焦显微镜，该显微镜将充当多源 在山区家庭医疗中心的核心设施中进行仪器。该系统将大大 加强进行VA资助研究和多重研究的主要用户的研究 次要用户。虽然该显微镜主要用于VA资助的研究，但仪器 还将向寻求获得初步的新调查人员和调查人员提供时间 提交VA赠款的数据。山地弗吉尼亚州医疗中心目前没有 共聚焦显微镜，目前依靠相邻的收费工具 大学。虽然该显微镜继续被研究者广泛使用 参与此应用程序，VA研究人员不是仪器使用的优先事项， 使用的费用很陡。共焦技术在最近几个 年份以及我们目前要求的研究问题，要求我们采用最新 我们当前仪器上无法使用的ART成像技术。我们显然在 我们当前基于收费的工具无法满足VA资助的需求的点 研究人员进行了多个VA优点和DOD资助的研究，依赖于共聚焦显微镜。 在我们VA的200英里半径内没有其他共聚焦显微镜。所以， 该应用程序解决了巨大的研究需求。 VA山区的房屋有很强的 机构对共聚焦显微镜的获取和维护的承诺。 500 已经分配了适当装备来容纳乐器的平方英尺的房间。 一旦初始保修期，已经制定了为服务合同承销服务合同的规定 已经过期了。已经成立了一个咨询委员会。博士学位科学家，有 具有共焦显微镜的经验，将在一个协助下监督该设施 经验丰富的研究技术员。该工具将大大改善研究工作 在弗吉尼亚州的山地，旨在改善退伍军人的健康。