H/H-ASTHMA HGC

H/H-哮喘 HGC

• 批准号: 7607823
• 负责人: FLOYD J MALVEAUX
• 金额: $ 0.82万
• 依托单位: HOWARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607823
• 关键词: African American; Alleles; Area; Asthma; Complex; Computer Retrieval of Information on Scientific Projects Database; Development; Diagnostic; Disease; Economic Burden; Environmental Risk Factor; Functional disorder; Funding; Genetic; Genetic Variation; Goals; Grant; Human; IgE; Immune response; Incidence; Institution; Morbidity - disease rate; Pathogenesis; Patients; Play; Predisposition; Prevention strategy; Proteins; Publishing; Purpose; Recruitment Activity; Reporting; Research; Research Personnel; Resources; Role; Source; Thinking; United States National Institutes of Health; Universities; Washington; cockroach allergen; genetic risk factor; health economics; improved; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Asthma is a complex, multifactorial disease resulting from biologic interaction between multiple gene products and environmental factors. The current thoughts that genetics play a major role in asthma pathophysiology and published reports of higher incidence of asthma and assoicated morbidity and mortlity in African American, it sems imperative that more studies are needed to identify genetic factors attributable to asthma development. The purpose of this study is to identify genetic risk factors contributing towards development of asthma. We plan to recruit 100 asthma patients in the Washington, D. C. area for this study. With our collaborators at Johns Hopkins University, we aim to identify allelic variants that confer susceptibility towards a specific IgE immune response to cockroach allergen in humans. Identification of asthma susceptible alleles will help in better understanding of its pathogenesis, with the ultimate goal of improving preventive strategies, diagnostic tools, and therapies for this disease which is now a major health and economic burden for peoples especially in African Americans.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 哮喘是一种复杂的多因素疾病，由多种基因产物和环境因素之间的生物相互作用引起。目前认为遗传学在哮喘病理生理学中发挥着重要作用，并且已发表的非裔美国人哮喘发病率及相关发病率和死亡率较高的报告似乎迫切需要更多的研究来确定可归因于哮喘发展的遗传因素。本研究的目的是确定导致哮喘发生的遗传风险因素。我们计划在华盛顿特区招募 100 名哮喘患者进行这项研究。我们与约翰·霍普金斯大学的合作者一起，旨在鉴定赋予人类对蟑螂过敏原特定 IgE 免疫反应易感性的等位基因变异。鉴定哮喘易感等位基因将有助于更好地了解其发病机制，最终目标是改进这种疾病的预防策略、诊断工具和治疗方法，这种疾病现在已成为人们尤其是非裔美国人的主要健康和经济负担。