Development of an SPF Macaca nemestrina Breeding Colony

SPF 猕猴饲养群的开发

基本信息

批准号：
8272803
负责人：
ROBERT J. ADAMS
金额：
$ 60.03万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-09-21 至 2012-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8272803
关键词：
Acquired Immunodeficiency Syndrome Age Alleles Animals Area Biology Bioterrorism Breeding Cell physiology Communities Complex Country Data Databases Development Disease Progression Epidemiology Family suidae Female Funding Future Goals Grant Haplotypes Human Immune response Immunology Laboratories Macaca Macaca mulatta Macaca nemestrina Marketing Medical Research Medicine Methodology Modeling Molecular Genetics Monkeys Phase Price Primates Process Production Publishing Reagent Recording of previous events Records Research Research Activity Research Infrastructure Research Personnel Resources Retroviridae SIV Sales Source Specific Pathogen Frees Tail Testing Tissues United States National Institutes of Health Universities Viral Virginia Virus Washington Western Blotting animal colony cohort comparative computerized experience germ free condition human disease improved male meetings nonhuman primate offspring programs

项目摘要

DESCRIPTION (provided by applicant): The use of pig-tailed macaques (Macaca nemestrina) in all areas of medical research has increased to the point that demand exceeds supply and increased research activity in bioterrorism will undoubtedly increase the demand for nonhuman primates in the near future. The resulting increased prices and increased delays in procuring monkeys hinder the ability to conduct funded research. Researchers in many fields have experienced similar disruptions in their ability to conduct research. The primary objective of this application is to develop a new national resource that will supply SPF pig-tailed macaques to researchers across the country. The proposed resource-related research would also further the usefulness of the pig-tailed macaque as a research model through the development of key reagents for research in the immunology. Pig-tailed macaques are used in a wide variety of medical research. AIDS research is the newest demand on the supply of pig-tailed macaques, but in the last 5 years, 75% of published studies with pig-tailed macaques have been in non-AIDS research areas. As demand for pig-tailed macaques has increased, paradoxically, commercial breeding sources have declined production. Covance, disbanded their pig-tailed macaque breeding program, and LABS of Virginia reduced their breeding stock by one third. The Yerkes and Washington National Primate Research Centers (WaNPRC)/Tulane NRPRC and the New Iberia Primate Research Center are the only facilities with a sizable pig-tailed macaque breeding program. Despite recent increases in their breeding capacity, officials at WaNPRC indicate that they will not be able to meet the current and expected demand for pig-tailed macaques in research. Funding of this application will allow the continued expansion of an existing colony to approximately 125 breeding-age females yielding enough animals to maintain the breeding stock and produce approximately 62 offspring each year. With a colony this size, 50% of the male offspring would be made available for sale at market prices to researchers outside of the Johns Hopkins University. Demand for pig-tailed macaques from NIH funded grants already exceeds current supplies. New national research infrastructure must be developed to help meet existing and future research demands.

描述（由申请人提供）：猪尾猕猴（Macaca nemestrina）在所有医学研究领域的使用已经增加到供不应求的程度，并且生物恐怖主义研究活动的增加无疑将增加近期对非人类灵长类动物的需求未来。由此导致的价格上涨和采购猴子的延误增加阻碍了进行资助研究的能力。许多领域的研究人员的研究能力都经历了类似的破坏。该应用程序的主要目标是开发一种新的国家资源，为全国各地的研究人员提供 SPF 猪尾猕猴。拟议的资源相关研究还将通过开发免疫学研究的关键试剂，进一步提高猪尾猕猴作为研究模型的实用性。猪尾猕猴被广泛用于各种医学研究。艾滋病研究是对猪尾猕猴供应的最新需求，但在过去5年中，已发表的猪尾猕猴研究中有75%属于非艾滋病研究领域。矛盾的是，随着对猪尾猕猴的需求增加，商业养殖来源的产量却下降了。科文斯解散了他们的猪尾猕猴繁育计划，弗吉尼亚实验室减少了三分之一的繁育种群。耶基斯和华盛顿国家灵长类动物研究中心 (WaNPRC)/杜兰 NRPRC 和新伊比利亚灵长类动物研究中心是唯一拥有大规模猪尾猕猴繁育计划的机构。尽管最近其繁殖能力有所提高，但 WaNPRC 的官员表示，他们将无法满足当前和预期的猪尾猕猴研究需求。这项申请的资助将使现有的群体继续扩大到大约 125 只繁殖年龄的雌性，产生足够的动物来维持种畜并每年产生大约 62 只后代。对于如此规模的群体，50% 的雄性后代将以市场价格出售给约翰·霍普金斯大学以外的研究人员。美国国立卫生研究院资助的猪尾猕猴的需求已经超过了目前的供应量。必须开发新的国家研究基础设施，以帮助满足现有和未来的研究需求。