Synaptic processing in the basal ganglia

基底神经节的突触处理

基本信息

批准号：
7591271
负责人：
DAVID J PERKEL
金额：
$ 39.24万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-03-01 至 2013-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7591271
关键词：
6-Cyano-7-nitroquinoxaline-2,3-dione AMPA Receptors Address Adolescent Adult Affect Aggressive behavior Agonist Anterior Area Auditory Autistic Disorder Automobile Driving Axon Basal Ganglia Behavior Bicuculline Biological Models Birds Brain region Cells Cognitive Complex Courtship Denervation Dependence Disease Dopamine Dopamine D2 Receptor Dopamine Receptor Enkephalins Fathers Figs - dietary Foundations Globus Pallidus Glutamate Receptor Goals Human Huntington Disease In Situ Hybridization In Vitro Inhibitory Synapse Interdisciplinary Study Label Learning Light Mammals Measures Mediating Memory Messenger RNA Modeling Modification Molecular Molecular Profiling Motivation Nerve Neural Pathways Neurons Neuropeptides Output Parkinson Disease Pathway interactions Play Population Presynaptic Terminals Process Production Prosencephalon Receptor Activation Research Role Scanning Schizophrenia Signal Transduction Social Behavior Songbirds Speech Structure Substance P Synapses Synaptic plasticity Testing Thalamic Nuclei Thalamic structure Ventral Tegmental Area Vertebrates Whole-Cell Recordings Work auditory feedback autism spectrum disorder cognitive function dopamine system extracellular in vitro activity in vivo information processing insight interest male motor control motor learning neuronal cell body novel patch clamp postsynaptic public health relevance receptor research study response vocal learning zebra finch

项目摘要

DESCRIPTION (provided by applicant): Vocal learning in songbirds is a unique, experimentally accessible model of human vocal learning that also exemplifies the acquisition of complex social behavior. A male songbird learns his courtship song by first memorizing his father's song, and later using auditory feedback to match his own song to his memory of his father's song. One major advantage to this model system is the existence of separate forebrain circuits involved in producing the song and in learning it. The pathway needed for learning song involves the basal ganglia, a set of brain regions known in mammals to be important for motor control, motor learning and a variety of cognitive functions. Because of the relatively simple circuitry for song learning, we hypothesize that understanding vocal learning in songbirds will provide general insights into learning mechanisms in mammals, including humans. Specifically, we propose to explore cellular mechanisms underlying information transfer and processing through the learning circuit. The experiments proposed here will use electrophysiological and neuroanatomical approaches to understand the structural, functional and molecular components of the wiring of this pathway. We will: (1) determine the cellular specializations underlying an unusually powerful inhibitory synapse in the learning circuit; (2) test whether that "inhibitory" synapse can drive activity in postsynaptic neurons in vivo; (3) determine the dopamine receptors and neuropeptides in key neurons in one basal ganglia structure essential for learning; (4) test for functional connections in a novel anatomically characterized pathway that could provide song-related information to neurons of the dopamine system; and (5) measure when dopamine is released in the learning circuit, as a first test of whether dopamine may play a role in song learning. These experiments will provide necessary fundamental information about how the avian learning circuit accomplishes its normal function. Because of the strong foundation that we and others have built comparing avian song learning circuits with basal ganglia circuits in mammals, the results will yield insights more broadly into how basal ganglia circuits can contribute to learning of complex behavior. They will lay the foundation for higher-level experiments aimed at manipulating information processing in the learning circuit to alter learning in a predictable fashion. Although this work is focused on the basic mechanisms underlying cognitive function, because a variety of disorders such as autism spectrum disorder, schizophrenia, Parkinson disease and Huntington disease involve the basal ganglia, this research also has the potential to have long- term impact on those disorders. PUBLIC HEALTH RELEVANCE These experiments take advantage of the strong parallels that we have demonstrated between songbird basal ganglia circuits and those of mammals. Together, they address cellular mechanisms of information processing in the basal ganglia that underlie learning of a complex social behavior in juveniles and modification of such behavior in adults. The results will guide understanding of the role of the basal ganglia in cognitive processes such as learning and ultimately may shed light on disorders in which the basal ganglia are implicated, such as autism and schizophrenia.

描述（由申请人提供）：鸣禽的声音学习是一种独特的、可通过实验获得的人类声音学习模型，也例证了复杂社会行为的习得。雄性鸣禽通过首先记住父亲的歌曲来学习求爱歌曲，然后利用听觉反馈将自己的歌曲与记忆中的父亲歌曲相匹配。该模型系统的一个主要优点是存在独立的前脑回路来参与歌曲的制作和学习。学习歌曲所需的通路涉及基底神经节，这是哺乳动物中已知的一组对运动控制、运动学习和各种认知功能很重要的大脑区域。由于歌曲学习的电路相对简单，我们假设了解鸣禽的声音学习将为包括人类在内的哺乳动物的学习机制提供一般性的见解。具体来说，我们建议通过学习回路探索信息传输和处理背后的细胞机制。这里提出的实验将使用电生理学和神经解剖学方法来了解该通路接线的结构、功能和分子成分。我们将：（1）确定学习回路中异常强大的抑制性突触背后的细胞特化；（2）测试“抑制性”突触是否可以驱动体内突触后神经元的活动； (3) 确定学习所必需的基底神经节结构中关键神经元的多巴胺受体和神经肽； (4) 测试一种新的解剖学特征通路中的功能连接，该通路可以向多巴胺系统的神经元提供与歌曲相关的信息；（5）测量学习回路中多巴胺何时释放，作为多巴胺是否在歌曲学习中发挥作用的第一个测试。这些实验将提供有关鸟类学习回路如何实现其正常功能的必要基本信息。由于我们和其他人在比较鸟类鸣叫学习回路与哺乳动物的基底神经节回路方面建立了坚实的基础，因此结果将更广泛地了解基底神经节回路如何有助于复杂行为的学习。它们将为更高水平的实验奠定基础，这些实验旨在操纵学习回路中的信息处理，以可预测的方式改变学习。尽管这项工作的重点是认知功能的基本机制，但由于自闭症谱系障碍、精神分裂症、帕金森病和亨廷顿病等多种疾病都涉及基底神经节，因此这项研究也有可能对这些疾病产生长期影响。失调。公共健康相关性这些实验利用了我们已经证明的鸣禽基底神经节回路与哺乳动物基底神经节回路之间的强烈相似性。他们共同探讨了基底神经节信息处理的细胞机制，该机制是青少年复杂社会行为学习和成人此类行为修正的基础。这些结果将指导人们理解基底神经节在学习等认知过程中的作用，并最终可能揭示基底神经节所涉及的疾病，例如自闭症和精神分裂症。