Proof of Principle for Zoom in Breast PET/CT

放大乳房 PET/CT 原理证明

• 批准号: 8127492
• 负责人: Felipe Godinez
• 金额: $ 3.28万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8127492
• 关键词: Address; Age-Years; Algorithms; Biomedical Engineering; Blood capillaries; Breast; Breast Cancer Detection; Bronchi; Caliber; Cancer Detection; Cause of Death; Cessation of life; Clinical Trials; Death Rate; Development; Devices; Diagnostic; Disease; Effectiveness; Electronics; Engineering; Equipment; Event; Goals; Gold; Hispanics; Image; Imaging Device; Imaging Techniques; Investigation; Lesion; Lung; Lutetium; Malignant Neoplasms; Mammography; Measurement; Measures; Mechanics; Minority; Modality; Modification; Monitor; Neoadjuvant Therapy; Ocular orbit; Operative Surgical Procedures; Performance; Positioning Attribute; Positron-Emission Tomography; Primary Neoplasm; Publishing; Reading; Research; Research Personnel; Resolution; Resources; Role; Rotation; Sampling; Science; Screening procedure; Source; Specificity; Staging; System; Techniques; Time; TimeLine; Tracer; Training; Tube; Visual; Woman; capillary; chemotherapy; data acquisition; design; detector; experience; fluorodeoxyglucose positron emission tomography; follow-up; image reconstruction; improved; malignant breast neoplasm; millimeter; molecular imaging; novel; photomultiplier; reconstruction; response; tool; tumor; uptake

DESCRIPTION (provided by applicant): Due to increased screenings with better screening tools breast cancer is detected earlier. This implies that higher resolution diagnostic tools are required for managing smaller sized tumors. Fluorodeoxyglucose positron emission tomography (PET) has been known to be an effective modality in staging primary tumors and monitoring chemotherapy. Research has shown that FDG-PET is capable of predicting pathological response of primary tumor to chemotherapy agents, but the spatial resolution of current systems limits them to tumors larger than 2 cm. The goal of this project is to prove that the spatial resolution of present dedicated breast PET/CT systems can be improved to sub millimeter spatial resolution using a high-resolution detector insert. In order to prove this principle this project aims specifically to construct and characterized a detector with tiny scintillating crystals made of lutetium oxyorthosilicate. This detector is then adapted to a dedicated PET system previously designed and fabricated in this lab. After this the combined performance of the high-resolution detector and the moderate resolution detector will be characterized. The spatial resolution after tomographic reconstruction and sensitivity will be measured. The proposed research plan is tailored to engage the applicant in the participation of translational cancer bioengineering research. The sponsor will provide the resources, space, and equipment for the applicant to carry out the necessary science and engineering tasks. A timeline of courses and field related seminars are included in the training plan to enhance the training experience. The accomplishments of the stated goals will better prepare the applicant in becoming a translational researcher and representative of Hispanic minorities in the field, hence promoting diversity. PUBLIC HEALTH RELEVANCE: The proposed research plan is tailored to engage the applicant in the participation of translational cancer bioengineering research. The sponsor will provide the resources, space, and equipment for the applicant to carry out the necessary science and engineering tasks to develop a cancer detection device. The accomplishments of the stated goals will better prepare the applicant in becoming a translational researcher and representative of Hispanic minorities in the field, hence promoting diversity. !

描述（由申请人提供）：由于使用更好的筛查工具增加了筛查，乳腺癌可以更早地被发现。这意味着需要更高分辨率的诊断工具来管理较小尺寸的肿瘤。已知氟脱氧葡萄糖正电子发射断层扫描 (PET) 是对原发肿瘤进行分期和监测化疗的有效方法。研究表明，FDG-PET能够预测原发肿瘤对化疗药物的病理反应，但现有系统的空间分辨率限制了它们只能检测大于2厘米的肿瘤。该项目的目标是证明使用高分辨率探测器插件可以将现有专用乳房 PET/CT 系统的空间分辨率提高到亚毫米空间分辨率。为了证明这一原理，该项目的具体目标是构建和表征具有由氧原硅酸镥制成的微小闪烁晶体的探测器。然后将该探测器适应于本实验室之前设计和制造的专用 PET 系统。此后，将表征高分辨率探测器和中等分辨率探测器的组合性能。将测量断层扫描重建后的空间分辨率和灵敏度。拟议的研究计划是为让申请人参与转化癌症生物工程研究而量身定制的。赞助者将为申请人提供资源、空间和设备，以执行必要的科学和工程任务。培训计划中包含课程时间表和现场相关研讨会，以增强培训体验。实现既定目标将使申请人更好地准备成为该领域的转化研究员和西班牙裔少数族裔的代表，从而促进多样性。 公共健康相关性：拟议的研究计划是为让申请人参与转化癌症生物工程研究而量身定制的。申办者将为申请人提供资源、空间和设备，以执行开发癌症检测设备所需的科学和工程任务。实现既定目标将使申请人更好地准备成为该领域的转化研究员和西班牙裔少数族裔的代表，从而促进多样性。 ！