Regulation of the Warburg Effect in Cancer

癌症中瓦尔堡效应的调节

• 批准号: 8146230
• 负责人: Heather Christofk
• 金额: $ 231万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8146230
• 关键词: Address; Antineoplastic Agents; Drug Delivery Systems; Maintenance; Malignant Neoplasms; Metabolism; Molecular; Normal Cell; Oxidative Phosphorylation; Oxygen; Production; Regulation; Research; Role; Testing; Therapeutic; Warburg Effect; abstracting; aerobic glycolysis; cancer cell; cancer therapy; in vivo; neoplastic cell; novel; public health relevance; tumor growth; tumorigenesis

DESCRIPTION (Provided by the applicant) Abstract: The metabolism of cancer cells is different from that of their normal cell counterparts. Known as the Warburg effect (or aerobic glycolysis), this altered tumor cell metabolism is characterized by enhanced lactate production with reduced oxidative phosphorylation even in the presence of oxygen. Although this observation was first made over 75 years ago, how cancer cells establish this altered metabolism and whether it is important for tumorigenesis remains unknown. Our research aims to determine the molecular mechanisms by which tumor cells establish and maintain the Warburg effect in cancer, to definitively address whether the Warburg effect is necessary for tumor growth, and to identify novel cancer drug targets responsible for maintenance of the Warburg effect in vivo. This study will determine whether targeting cancer metabolism is a viable approach for cancer therapy and will better define the role of metabolism for tumor growth. Public Health Relevance: This proposed research will investigate causes of the altered metabolism found in cancer cells. It will also test whether targeting this altered metabolism is a viable strategy for cancer therapeutics.

描述（申请人提供） 摘要：癌细胞的代谢不同于其正常细胞对应物的代谢。这种改变的肿瘤细胞代谢被称为WARBURG效应（或有氧糖酵解），其特征是乳酸产生增强，即使在存在氧气的情况下，氧化磷酸化也会降低。尽管该观察结果首先是在75年前进行的，但癌细胞如何建立这种改变的新陈代谢以及对肿瘤发生重要性仍然未知。我们的研究旨在确定肿瘤细胞在癌症中建立和维持沃伯格效应的分子机制，以确定解决Warburg效应是否对肿瘤生长是必不可少的，并确定负责维持沃堡效应的新型癌症药物靶标。这项研究将确定靶向癌症代谢是否是癌症治疗的可行方法，并将更好地定义代谢在肿瘤生长中的作用。 公共卫生相关性：这项拟议的研究将调查癌细胞中新陈代谢改变的原因。它还将测试靶向这种改变的新陈代谢是否是癌症治疗剂的可行策略。