Evaluating EHR-based, Point-of-Care Trial Recruitment Across Clinical Settings

评估跨临床环境的基于 EHR 的护理点试验招募

• 批准号: 7939669
• 负责人: PETER J. EMBI
• 金额: $ 14.39万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2010-10-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7939669
• 关键词: Accounting; Address; Affect; Clinical; Clinical Research; Clinical Trials; Communities; Crossover Design; Data; Effectiveness; Electronic Health Record; Engineering; Enrollment; Environment; Evaluation; Funding Agency; General Practitioners; Goals; Group Interviews; Health; Health Information System; Health system; Healthcare; Healthcare Systems; Human; Individual; Informatics; Intervention; Intervention Studies; Interview; Knowledge; Lead; Medical; Medicine; Mission; Modeling; Modification; Patients; Physicians; Population; Primary Health Care; Process; Qualitative Methods; Randomized; Recruitment Activity; Relative (related person); Research; Research Personnel; Science; Series; Solutions; Specialist; Study Subject; Summary Reports; Surveys; Testing; Universities; Work; base; biomedical informatics; health information technology; improved; innovation; knowledge base; medical specialties; point of care; preference; success

DESCRIPTION (provided by applicant): Inadequate recruitment of eligible subjects for clinical trials is a major impediment to the advancement of medicine. Use of an EHR-based, point-of-care Clinical Trial Alert (CTA) approach has been shown to significantly improve recruitment in a prior study and shows promise for wider use. However, fundamental gaps in our knowledge regarding determinants of EHR-based, point-of-care trial recruitment and the applicability of the CTA approach in different clinical settings must be addressed before potential benefits can be realized. Our long-term goal is to improve clinical research by leveraging health information technology. The objective of this particular application is to evaluate the CTA approach's effect on physicians' rates of subject recruitment across different clinical settings and determine the factors that effect this point-of-care recruitment in HER-equipped environments. Our central hypothesis is that by addressing the factors that influence trial recruitment participation, an EHR-based, point-of-care CTA approach will prove broadly efficacious. Guided by our strong preliminary data, we will test our hypotheses by pursuing two specific aims: (1) Determine the impacts on trial recruitment of an EHR-based CTA approach in different clinical settings within and across healthcare systems; (2) Identify the range of stakeholders' perceived barriers, facilitators, and information needs regarding HER-based, point-of-care recruitment in different clinical settings to inform improvements in the CTA approach. Under the first aim, we will perform a series of randomized cross-over designed interventions to evaluate CTA's impact on recruitment among primary care and subspecialist physicians across three healthcare systems. Under the second aim, we will conduct interviews and surveys of stakeholders including clinicians, patients and researchers involved in the CTA-driven process to ascertain their perceived barriers, facilitators, and information needs regarding point-of-care recruitment. Finally, we will analyze the findings from both aims to produce a summary report that will inform modifications to the CTA approach and next steps in this line of inquiry. This approach is innovative in that it will apply complementary methodological approaches to answer important questions regarding the utility of clinical trial recruitment using a promising EHR-based approach in a range of healthcare settings and the factors that influence its impact. The proposed research is significant because it is expected to advance our knowledge regarding EHR-facilitated trial recruitment at the point-of care.

描述（由申请人提供）： 用于临床试验的合格受试者的招募不足是医学进步的主要障碍。已经证明，使用基于EHR的基于EHR的，即保健临床试验警报（CTA）方法可以显着改善先前研究的招聘，并显示出更广泛使用的希望。但是，在我们在实现潜在的益处之前，必须解决有关基于EHR的确定因素，CTA方法招募和CTA方法在不同临床环境中的适用性的基本差距。我们的长期目标是通过利用健康信息技术来改善临床研究。该特定应用的目的是评估CTA方法对医师在不同临床环境中受试者招募率的影响，并确定对具有HERIPERIPPATION环境中这种保健招募的因素。我们的中心假设是，通过解决影响试验招聘参与的因素，基于EHR的CTA CTA方法将被证明是广泛有效的。在我们强大的初步数据的指导下，我们将通过追求两个具体目标来检验我们的假设：（1）确定对医疗保健系统内外不同临床环境中基于EHR的CTA方法的试验招募的影响； （2）确定利益相关者在不同临床环境中基于其基于的，即保健的招聘的感知障碍，促进者和信息需求的范围，以告知CTA方法的改进。在第一个目标下，我们将执行一系列随机跨界设计的干预措施，以评估CTA对三个医疗保健系统中初级保健和专科医师招聘的影响。在第二个目标下，我们将对参与CTA驱动过程的临床医生，患者和研究人员进行访谈和调查，以确定其感知的障碍，促进者以及有关招聘点的招聘的信息需求。最后，我们将分析两种目的的发现，以制定摘要报告，该报告将为CTA方法和此询问的下一步提供修改。这种方法具有创新性，因为它将采用互补的方法学方法来回答有关临床试验招聘效用的重要问题，该问题在一系列医疗保健环境中使用了有希望的基于EHR的方法及其影响其影响的因素。拟议的研究很重要，因为有望提高我们在医疗点上接受EHR的试验招聘的知识。