COCAINE/ALCOHOL EXPOSURE AND INFANT OUTCOME

可卡因/酒精接触和婴儿结局

• 批准号: 2014026
• 负责人: LINDA L LAGASSE
• 金额: $ 7.39万
• 依托单位: WOMEN AND INFANTS HOSPITAL-RHODE ISLAND
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-30 至 1998-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2014026
• 关键词: alcoholism /alcohol abuse; clinical research; cocaine; disease /disorder proneness /risk; drug abuse; embryo /fetus toxicology; ethanol; functional ability; human subject; interview; maternal behavior; medical complication; mother child interaction; newborn human (0-6 weeks); prenatal care; prognosis

Studies on the effects of prenatal cocaine exposure on infant outcome show an inconsistent pattern of results due, in part, to 1) confounding of cocaine with other substances most notably alcohol; 2) problems in the measurement of prenatal substance exposure; 3) failure to include maternal biobehavioral risk factors related to prenatal substance use that may also affect infant neurobehavioral outcome; and 4) problems with neurobehavioral assessments that may not be sensitive to the effects of prenatal drug exposure. The four objectives of the proposed study are to: 1) determine the combined effects of alcohol and cocaine on infant neurodevelopmental outcome; 2) use sophisticated clinical interview measures of cocaine and alcohol use to provide a more reliable estimate of prenatal substance exposure; 3) include measures of maternal biobehavioral risk factors in addition to measures of prenatal substance exposure that may relate to infant neurobehavioral outcome and 4) use "state of the art" measures from the neurobehavioral battery that we developed for NIDA for the NIH Maternal Lifestyles multicenter longitudinal study of prenatal drug exposure and child outcome. The sample will include 100 infants prenatally exposed to cocaine plus alcohol, only alcohol, and unexposed controls. Marijuana and nicotine exposure, gestational age, and prenatal care will be included as covariates. Mothers will be administered the time line follow-back structured interview method to measure prenatal cocaine and alcohol exposure and a biobehavioral risk factor battery that includes measures of pre-pregnancy substance use history, medical complications, neuropsychological function, mental health issues, familial psychiatric and substance use histories. Infants will be tested at birth and one month on the NICU Network Neurobehavioral Scale and at one month on mother-infant feeding interaction. Data analysis will determine if infants exposed to cocaine and alcohol show poorer neurobehavioral outcome at birth and one month than infants exposed only to alcohol and the effects of maternal biobehavioral risk factors on infant neurobehavioral outcome.

研究产前可卡因对婴儿结局的影响 显示出不一致的结果模式，部分应为1）混淆 可卡因与其他物质最著名的酒精； 2）问题 测量产前物质暴露； 3）未包括 与产前药物有关的母体生物行为危险因素 这也可能影响婴儿神经行为预后； 4） 神经行为评估可能对 产前药物暴露。拟议研究的四个目标是： 1）确定酒精和可卡因对婴儿的综合作用 神经发育结果； 2）使用复杂的临床访谈 可卡因和酒精使用的措施以提供更可靠的估计 产前物质暴露； 3）包括孕产妇的措施 生物行为危险因素除了产前物质的措施 可能与婴儿神经行为结局有关的暴露和4）使用 我们从神经行为电池中采取的“最新技术”措施 为NIDA开发的NIH母体生活方式多中心 产前药物暴露和儿童结局的纵向研究。这 样本将包括100名在产前暴露于可卡因加的婴儿 酒精，只有酒精和未暴露的对照。大麻和尼古丁 接触，胎龄和产前护理将被包括在内 协变量。母亲将被管理时间表跟随 测量产前可卡因和酒精的结构化访谈方法 曝光和包括措施的生物行为风险因素电池 孕前药物使用病史，医学并发症， 神经心理学功能，心理健康问题，家族性精神病学 和物质使用历史。婴儿将在出生时进行测试，一个 NICU网络神经行为量表上的月份，一个月 母喂养相互作用。数据分析将确定是否 暴露于可卡因和酒精的婴儿表现出较差的神经行为 出生时的结局和一个月的结果比仅暴露于酒精的婴儿 产妇生物行为风险因素对婴儿的影响 神经行为结果。