OPTION PERIOD ONE (1): TASK AREA B.2. - COHORT EXAM 4 AND EXAM CLOSEOUT FOR JACKSON HEART STUDY (JHS) COORDINATING CENTER (CC).

选择期一 (1)：任务领域 B.2。

基本信息

批准号：
10809556
负责人：
April P Carson
金额：
$ 286.87万
依托单位：
UNIVERSITY OF MISSISSIPPI MED CTR
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-06-13 至 2023-12-12
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10809556
关键词：
Abdomen Adverse event African American African American population Age Ancillary Study Aorta Area Atherosclerosis Risk in Communities Back Behavioral Biochemical Biological Biological Assay Biological Specimen Banks Biomedical Research Blood specimen Candidate Disease Gene Cardiovascular Diseases Certification Clinical Community Health Education Community Outreach Consent Contractor County Cryopreservation DNA Data Data Collection Data Set Disease Echocardiography Educational Status Electronics Enrollment Environmental Risk Factor Event Family Family Sizes Funding Genetic Genome Scan Health Personnel Hospitalization Injury Institutional Review Boards Investigation Jackson Heart Study Lymphocyte Mathematics Measures Monitor National Heart, Lung, and Blood Institute Paper Participant Performance Policies Preparation Procedures Psychosocial Factor Publications Quality Control Recommendation Reporting Research Research Personnel Risk Factors Sampling Science Scientist Socioeconomic Factors System Training Training Programs Validation Vital Status Work X-Ray Computed Tomography aged biomedical profession cardiac magnetic resonance imaging cardiovascular disorder risk career clinically relevant cohort college data cleaning disorder risk follow-up genetic risk factor healthy lifestyle heart imaging high school interest member metropolitan programs quality assurance recruit residence sociocultural determinant undergraduate student underrepresented minority student web site

项目摘要

The Jackson Heart Study (JHS), initiated in 1998, is a longitudinal investigation of genetic and environmental risk factors associated with the disproportionate burden of cardiovascular disease (CVD) in African-Americans. In addition, the JHS performs a variety of community education and outreach activities to promote healthy lifestyles and reduce disease risk burden. It also conducts college undergraduate and graduate-level training programs and high school science and math enrichment programs to prepare and encourage underrepresented minority students to pursue biomedical careers. (www.jacksonheartstudy.org/). The JHS represents an expansion of the Jackson Field Center of the Atherosclerosis Risk in Communities (ARIC) study (www2.cscc.unc.edu/aric/), to broaden data collection in an African- American population and to increase access to and participation of African American populations and scientists in biomedical research and professions. The study recruited 5306 African-American residents, including 3,732 residents also enrolled in ARIC, living in the Jackson, MS, metropolitan area of Hinds, Madison, and Rankin Counties. Enrolled JHS participants, initially aged 20 - 90 years, received three back-to-back examinations (Exam 1, 2000-04; Exam 2, 2005-08; and Exam 3, 2009-13) and have been contacted annually. Findings on the rich set of data on physical, behavioral, genetic, and psychosocial factors have been presented in over 345 publications as of the end of 2016. Participant exams have produced extensive longitudinal data on traditional and putative CVD risk factors, socioeconomic and sociocultural factors, and biochemical analytes; and measures of subclinical disease from echocardiography, cardiac magnetic resonance imaging (MRI), and computed tomography (CT) scans of the heart, aorta, and abdomen. Stored biological samples have been assayed for putative biochemical risk factors and stored for future research. DNA has been extracted and lymphocytes cryopreserved for study of candidate genes, genome-wide scanning, expression, and other –omics investigations. The study included a nested component of 428 families with mean family size of 5 at baseline; today 331 families with at least 1 living member still actively participate. Participation of the surviving cohort has been high: 80% (N=4205) and 72% (N=3820) at each of the two respective follow-up examinations. Today the average cohort age is 68 years. Since baseline, cohort members have also been contacted every 12 months to obtain information on vital status, current residence, major illness or injury, and hospitalizations occurring between contacts to identify incident clinical CVD events of interest. Due to JHS’ shared cohort membership with ARIC, the two studies cooperate with each other on events validation.

杰克逊心脏研究（JHS）于1998年启动，是1998年的纵向，在非裔美国人中，心血管疾病（CVD）的纵向负担，JHS还进行了各种社区教育和外展活动，以促进健康的生活方式和疾病。风险负担。社区动脉粥样硬化风险（ARIC）研究（www2.cscc.unc.edu/）Aden数据收集的JHS杰克逊领域的JHS麻风雨专业人士。 2，2005-08; 3，2009 - 13年），截至2016年底，已经在345个出版物中介绍了有关物理，行为，遗传和心理心理因素的丰富数据。参与者的检查纵向数据，从超声心动摄影，心脏磁共振（MRI）扫描（CT）心脏，Aorta，Aorta和Abdomecorples中，来自超临床疾病的生化分析物以及对亚临床疾病的措施已经进行了方形的风险因素，并储存了未来的研究，并为候选基因的研究，基因组扫描，表达，Andics投资提供了淋巴细胞的淋巴细胞。 TICIPATE的参与度很高：在两个随访期中，每两个随访的年龄都有80％（n = 4205）（n = 4205）（n = 3820）。有关生命状况，当前居住，重大疾病或伤害以及住院的信息，以识别互联网的临床CVD事件。