The Role of Nontraditional Glycemic Markers in Diabetes and Albuminuria

非传统血糖标志物在糖尿病和蛋白尿中的作用

• 批准号: 8508005
• 负责人: April P Carson
• 金额: $ 12.65万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-10 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8508005
• 关键词: Address; Admixture; Adult; Affect; African; African American; Albuminuria; Biological Assay; Cardiovascular Diseases; Characteristics; Chronic; Chronic Disease; Clinic; Clinical; Cohort Studies; Collection; Complications of Diabetes Mellitus; Coronary artery; Cross-Sectional Studies; Data; Data Collection; Development; Diabetes Mellitus; Diabetes prevention; Diabetic Angiopathies; Diagnosis; Discrimination; Elderly; Erythrocytes; Exhibits; Fostering; Fructosamine; Functional disorder; Genetic; Glycosylated Hemoglobin; Glycosylated hemoglobin A; Hemoglobin; Hyperglycemia; Individual; Kidney Diseases; Lead; Life Style; Measurement; Measures; Mentored Research Scientist Development Award; Monitor; Participant; Pathologic; Pathway interactions; Patient Recruitments; Patient Self-Report; Patients; Persons; Physiological; Population; Race; Recruitment Activity; Renal Glycosuria; Reporting; Research; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Research Training; Risk; Risk Factors; Role; Sampling; Scientist; Signal Pathway; Signal Transduction; Specimen; Statistical Methods; Stratification; Training; Training Activity; United States; United States National Institutes of Health; Visit; career development; diabetes risk; experience; glycemic control; glycosylated serum albumin; high risk; improved; metabolomics; new therapeutic target; prevent; prognostic; prospective; public health relevance; racial difference; skills; young adult

DESCRIPTION (provided by applicant): Diabetes is a chronic disease associated with an increased risk of microvascular complications. In the United States, 13% of adults have diabetes and an additional 30% of adults are at high risk of developing diabetes. Nontraditional glycemic markers glycated albumin (GA), fructosamine, and 1,5-anhydroglucitol (1,5-AG)) may provide additional prognostic information to identify individuals at high risk of developing diabetes and microvascular complications. GA, fructosamine, and 1,5-AG reflect short-term hyperglycemia and have been shown to exhibit physiologic effects, including the initiation of signaling pathways, that are active in the development of diabetes microvascular complications. Moreover, important racial differences in GA, fructosamine, and 1,5-AG levels have been reported with African-Americans having higher GA and fructosamine and lower 1,5-AG levels than whites among individuals with and without diabetes. The aims of this research project are: 1) to evaluate the association of GA, fructosamine, and 1,5-AG with incident diabetes; 2) to evaluate the association of GA, fructosamine, and 1,5-AG with prevalent and incident albuminuria; and 3) to evaluate racial differences in the association of GA, fructosamine, and 1,5-AG with diabetes and albuminuria. To address these aims, this study proposes to measure GA, fructosamine, and 1,5- AG using stored specimens from the Coronary Artery Risk Development in Young Adults (CARDIA) Study and build upon the existing infrastructure of this prospective cohort study that has an extensive collection of socio- demographic, lifestyle, and clinical variables. The findings from this study may be used to improve risk stratification and inform the development of new therapeutic targets to prevent diabetes and microvascular complications. This research project will also be instrumental in helping the candidate gain expertise in the relation of glycemic markers and metabolomics with diabetes complications for establishing research independence. To foster the candidate's research training and career development, specific training activities are proposed in: 1) diabetes and renal pathophysiology; 2) advanced statistical methods in risk prediction; 3) metabolomics; and 4) research recruitment, data collection, and study management which will facilitate the candidate's transition to an independent investigator. In summary, this Mentored Research Scientist Development Award will foster the candidate's professional development as an independent scientist by providing an opportunity to gain expertise in glycemic markers and metabolomics and their effects on diabetes and albuminuria risk.

描述（由申请人提供）：糖尿病是一种与微血管并发症风险增加相关的慢性疾病。在美国，13% 的成年人患有糖尿病，另外 30% 的成年人有患糖尿病的高风险。非传统血糖标志物糖化白蛋白 (GA)、果糖胺和 1,5-脱水葡萄糖醇 (1,5-AG) 可提供额外的预后信息，以识别罹患糖尿病和微血管并发症的高风险个体。 GA、果糖胺和 1,5-AG 反映短期高血糖，并已被证明具有生理效应，包括启动信号通路，这些通路在糖尿病微血管并发症的发展中发挥着积极作用。此外，据报道，GA、果糖胺和 1,5-AG 水平存在重要的种族差异，在患有和未患糖尿病的个体中，非裔美国人的 GA 和果糖胺水平高于白人，而 1,5-AG 水平较低。该研究项目的目的是： 1) 评估 GA、果糖胺和 1,5-AG 与糖尿病发生的关系； 2) 评估 GA、果糖胺和 1,5-AG 与流行和偶发蛋白尿的关联； 3) 评估 GA、果糖胺和 1,5-AG 与糖尿病和白蛋白尿相关性的种族差异。为了实现这些目标，本研究建议使用来自年轻人冠状动脉风险发展 (CARDIA) 研究的储存样本来测量 GA、果糖胺和 1,5-AG，并以这项前瞻性队列研究的现有基础设施为基础，该研究具有广泛收集社会人口、生活方式和临床变量。这项研究的结果可用于改善风险分层，并为预防糖尿病和微血管并发症的新治疗靶点的开发提供信息。该研究项目还将有助于帮助候选人获得血糖标志物和代谢组学与糖尿病并发症之间关系的专业知识，以建立研究独立性。为了促进候选人的研究培训和职业发展，建议开展以下具体培训活动：1）糖尿病和肾脏病理生理学； 2）先进的风险预测统计方法； 3）代谢组学； 4) 研究招募、数据收集和研究管理，这将有助于候选人过渡为独立研究者。总之，该指导研究科学家发展奖将通过提供获得血糖标志物和代谢组学及其对糖尿病和蛋白尿风险影响方面的专业知识的机会，促进候选人作为独立科学家的专业发展。