OPTION PERIOD ONE (1): TASK AREA B.2. - COHORT EXAM 4 AND EXAM CLOSEOUT FOR JACKSON HEART STUDY (JHS) FIELD CENTER (FC).

选择期一 (1)：任务领域 B.2。

基本信息

批准号：
10498463
负责人：
MARIO SIMS
金额：
$ 194.05万
依托单位：
UNIVERSITY OF MISSISSIPPI MED CTR
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-06-13 至 2022-06-12
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10498463
关键词：
Abdomen Adverse event African American Age Aorta Area Atherosclerosis Risk in Communities Back Behavioral Genetics Biochemical Biological Biological Assay Biological Specimen Banks Biomedical Research Blood Volume Blood specimen Candidate Disease Gene Cardiac Cardiovascular Diseases Clinic Clinical Cohort Studies Community Health Education Consent County Cryopreservation DNA Data Data Collection Data Set Disease Echocardiography Education and Outreach Educational Status Enrollment Environmental Risk Factor Event Family Family Sizes Funding Genetic Risk Genome Scan Health Personnel Hospitalization Injury Institutional Review Boards Investigation Jackson Heart Study Lymphocyte Magnetic Resonance Imaging Manuals Mathematics Measures Monitor National Heart, Lung, and Blood Institute Notification Observational Study Participant Performance Policies Population Procedures Protocols documentation Psychosocial Factor Publications Quality Control Reporting Risk Factors Sampling Schedule Science Scientist System Training Programs Validation Vital Status Work X-Ray Computed Tomography aged base biomedical profession cardiovascular disorder risk career clinically relevant clinically significant cohort college community living data cleaning data quality disorder risk follow-up healthy lifestyle heart imaging high school interest member metropolitan operation programs quality assurance recruit residence social culture socioeconomics undergraduate student underrepresented minority student web site

项目摘要

The Jackson Heart Study (JHS), initiated in 1998, is a longitudinal investigation of genetic and environmental risk factors associated with the disproportionate burden of cardiovascular disease (CVD) in African-Americans. In addition, the JHS performs a variety of community education and outreach activities to promote healthy lifestyles and reduce disease risk burden. It also conducts college undergraduate and graduate-level training programs and high school science and math enrichment programs to prepare and encourage underrepresented minority students to pursue biomedical careers. (www.jacksonheartstudy.org/). The JHS represents an expansion of the Jackson Field Center of the Atherosclerosis Risk in Communities (ARIC) study (www2.cscc.unc.edu/aric/), to broaden data collection in an African- American population and to increase access to and participation of African American populations and scientists in biomedical research and professions. The study recruited 5306 African-American residents, including 3,732 residents also enrolled in ARIC, living in the Jackson, MS, metropolitan area of Hinds, Madison, and Rankin Counties. Enrolled JHS participants, initially aged 20 - 90 years, received three back-to-back examinations (Exam 1, 2000-04; Exam 2, 2005-08; and Exam 3, 2009-13) and have been contacted annually. Findings on the rich set of data on physical, behavioral, genetic, and psychosocial factors have been presented in over 345 publications as of the end of 2016. Participant exams have produced extensive longitudinal data on traditional and putative CVD risk factors, socioeconomic and sociocultural factors, and biochemical analytes; and measures of subclinical disease from echocardiography, cardiac magnetic resonance imaging (MRI), and computed tomography (CT) scans of the heart, aorta, and abdomen. Stored biological samples have been assayed for putative biochemical risk factors and stored for future research. DNA has been extracted and lymphocytes cryopreserved for study of candidate genes, genome-wide scanning, expression, and other –omics investigations. The study included a nested component of 428 families with mean family size of 5 at baseline; today 331 families with at least 1 living member still actively participate. Participation of the surviving cohort has been high: 80% (N=4205) and 72% (N=3820) at each of the two respective follow-up examinations. Today the average cohort age is 68 years. Since baseline, cohort members have also been contacted every 12 months to obtain information on vital status, current residence, major illness or injury, and hospitalizations occurring between contacts to identify incident clinical CVD events of interest. Due to JHS’ shared cohort membership with ARIC, the two studies cooperate with each other on events validation.

杰克逊心脏研究（JHS）于1998年启动，是对非裔美国人心血管疾病（CVD）不成比例的伯恩（Burnen）相关的遗传和环境危险因素的纵向研究。此外，JHS还进行了各种社区教育和外展活动，以促进健康的生活方式并降低疾病风险伯恩。它还指挥大学本科和研究生级培训课程以及高中科学和数学丰富计划，以准备和鼓励代表性不足的少数民族学生从事生物医学职业。（www.jacksonheartstudy.org/）。 JHS代表了社区动脉粥样硬化风险（ARIC）研究（www2.cscc.unc.edu/aric/）的杰克逊野战中心的扩展，以扩大非裔美国人人口的数据收集，并增加非裔美国人人口和参与生物培训研究和科学家在生物学研究和专业中的参与。该研究招募了5306名非裔美国居民，其中包括3,732名居民，还招募了ARIC，住在杰克逊，MS，Hinds，Hinds，Madison和Rankin县的杰克逊地区。招募的JHS参与者最初年龄在20至90岁之间，接受了三项背靠背考试（考试1，2000-04;考试2，2005-08;和考试3，2009-13），并每年与之联系。截至2016年底，已经在345多个出版物中列出了有关物理，行为，遗传和社会心理因素的丰富数据集的发现。参与者的考试已经产生了有关传统和推定的CVD风险因素，社会经济和社会文化因素以及生化分析物的广泛纵向数据。来自超声心动图，心脏磁共振成像（MRI）以及心脏，主动脉和腹部的计算机断层扫描（CT）扫描的亚临床疾病的度量。存储的生物学样本已被指定针对推定的生化危险因素，并存储用于未来的研究。 DNA已被提取，并保存淋巴细胞，用于研究候选基因，全基因组扫描，表达和其他 - 词素研究。该研究包括基线时平均家庭大小为5的428个家庭的嵌套成分；今天，至少有1名活着成员的家庭仍在积极参与。在两个相对随访检查中的每一个中，幸存的队列的参与度很高：80％（n = 4205）和72％（n = 3820）。今天，平均队列年龄为68岁。自基准以来，也已经每12个月与队列成员联系一次，以获取有关生命状况，当前居住，重大疾病或伤害的信息，并且在接触之间进行住院，以识别事件的临床CVD感兴趣的事件。由于JHS与ARIC共享的队列成员资格，两项研究相互合作就事件验证。