Boston Early Adversity and Mortality Study (BEAMS): Linking Administrative Data to Long-Term Longitudinal Studies

波士顿早期逆境和死亡率研究 (BEAMS)：将行政数据与长期纵向研究联系起来

• 批准号: 10795559
• 负责人: Lewina Onyi Lee
• 金额: $ 10.32万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10795559
• 关键词: Address; Adolescent; Adult; Affect; Age; Aging; Alzheimer' s disease related dementia; Area; Atmosphere; Birth; Birth Records; Birth Weight; Boston; Cardiometabolic Disease; Cardiovascular Diseases; Censuses; Cessation of life; Characteristics; Child; Childhood; Chronic Disease; Cognitive; Data; Data Analytics; Data Set; Data Sources; Databases; Dementia; Dimensions; Disabled Persons; Elderly; Environment; Environmental Hazards; Family; Grant; Health; Hospitals; Individual; Intervention; Knowledge; Lead; Life; Link; Location; Longevity; Longitudinal Studies; Mediating; Mediator; Methods; Military Personnel; Modeling; Modification; Morbidity - disease rate; Municipalities; Neighborhoods; Non-Insulin-Dependent Diabetes Mellitus; Onset of illness; Outcome; Participant; Pathway interactions; Personality Traits; Persons; Policies; Poverty; Premature Mortality; Process; Public Health; Records; Research Design; Resources; Running; Sampling; Science; Siblings; Social support; Socioeconomic Status; Testing; Vital Statistics; Water; Woman; Work; adverse childhood events; age related; arm; cardiometabolic risk; childhood adversity; cognitive reserve; cohort; dementia risk; deprivation; design; digital; disorder risk; diverse data; early life adversity; high risk; human old age (65+); inner city; innovation; lead exposure; low socioeconomic status; male; men; middle age; mortality; mortality risk; novel strategies; offspring; older men; older women; parent grant; premature; prospective; psychosocial; psychosocial resources; psychosocial stressors; socioeconomics; therapy design; therapy development; transmission process; waterborne; young adult

ABSTRACT Adverse childhood experiences, such as poverty, psychosocial stressors, and environmental hazards, have been consistently linked to poor adult health. Despite the public health significance of such early adversity, the processes by which the “long arm of childhood” brings about morbidity in later life, including outcomes such as Alzheimer's disease and related dementias, cardiometabolic disease, and ultimately, mortality, remain largely unknown. Scientific progress in this area has been severely handicapped by two limitations intrinsic to nearly all longitudinal studies of aging: (1) reliance on retrospective assessments of early conditions, and (2) inadequate “lifespan data” on the intervening processes between childhood and old age. The Boston Early Adversity and Mortality Study (BEAMS) will tackle the limitation of retrospective data by using high-quality administrative record linkage. In Aim 1, we link contemporaneous information on early-life health, family, and environmental hazards from multiple databases (including recently digitalized vital and census records, hospital and military records, public data on water- and air-borne lead exposure) to longitudinal data collected on three cohorts of men who have been assessed repeatedly since 1938 (N=724) or 1961 (N=2280) in the greater Boston area. We extend linkage to siblings of the cohorts to include women and allow within-family comparisons. As the cohorts are 74%-94% deceased, record linkage will create an exceptionally rich, cradle- to-death dataset. In Aim 1, we test the hypothesis that early adversities in the psychosocial (e.g., cold or chaotic family environment), socioeconomic (e.g., impoverished neighborhood), and environmental (e.g., lead exposure) domains have independent and additive effects on poor health in older men and women. To address the second limitation noted above, Aim 2 bridges the knowledge gap on processes which transmit the effects of early adversity onto three age-related outcomes: Alzheimer's disease and related dementias, cardiometabolic disease, and all-cause mortality. Leveraging the cradle-to-grave data on these cohorts, we test mediational hypotheses regarding deficiency of socioeconomic (low SES) and psychosocial resources (low social support, extraversion, and conscientiousness), and limited cognitive reserve as candidate pathways. We will examine these mediators as age-specific levels and long-term trajectories in adulthood. We will use a coordinated data analytic approach to inform the replicability and generalizability of findings across the 3 socioeconomically-graded cohorts. Completion of these aims will advance state-of-the-art methods and causal knowledge on how multiple dimensions of early conditions affect late life health outcomes such as Alzheimer's disease and related dementias, cardiometabolic disease, and mortality risk. Findings are expected to inform policy and intervention efforts targeting the upstream determinants of early adversity, and ultimately prolong the span of good health.

抽象的 不良的童年经历，如心理贫困、社会压力和环境危害， 尽管这种早期逆境对公共卫生具有重要意义，但人们一直认为它与成人健康状况不佳有关。 “童年的长臂”导致晚年发病的过程，包括以下结果： 阿尔茨海默氏病和相关痴呆症、心脏代谢疾病以及最终的死亡率仍然在很大程度上 这一领域的科学进步几乎受到两个内在限制的严重阻碍。 所有关于衰老的纵向研究：(1) 依赖于对早期状况的回顾性评估，以及 (2) 关于童年和老年之间的干预过程的“寿命数据”不足。 逆境与死亡率研究（BEAMS）将通过使用高质量的回顾性数据来解决回顾性数据的局限性 在目标 1 中，我们将有关早期生命健康、家庭和健康的同期信息联系起来。 来自多个数据库的环境危害（包括最近数字化的生命和人口普查记录， 医院和军队记录、水和空气中铅暴露的公共数据）到收集的纵向数据 对自 1938 年 (N=724) 或 1961 年 (N=2280) 以来反复接受评估的三组男性进行了研究 我们将与同龄人的兄弟姐妹的联系扩大到包括女性并允许家庭内部成员。 由于队列中 74%-94% 已死亡，记录关联将创建一个异常丰富的摇篮- 在目标 1 中，我们测试了心理社会中的早期逆境（例如寒冷或 混乱的家庭环境）、公民社会（例如贫困社区）和环境（例如铅 暴露）领域对老年男性和女性的健康状况不佳具有独立和累加的影响。 针对上述第二个限制，目标 2 弥合了影响传递过程的知识差距 早期逆境对三种与年龄相关的结果的影响：阿尔茨海默病和相关的痴呆症， 利用这些队列的从摇篮到坟墓的数据，我们测试了心脏代谢疾病和全因死亡率。 关于社会经济资源（低SES）和心理社会资源（低SES）缺乏的中介假设 社会支持、外向性和责任心）和有限的认知储备作为候选途径。 我们将检查这些中介因素的年龄特定水平和成年期的长期轨迹。 协调的数据分析方法，以告知 3 个领域的研究结果的可复制性和普遍性 社会经济分级群体的完成将推进最先进的方法和因果关系。 关于早期疾病的多个维度如何影响晚年健康结果（例如阿尔茨海默病）的知识 疾病及相关痴呆、心脏代谢疾病和死亡风险的研究结果有望提供信息。 针对早期逆境的上游决定因素的政策和干预努力，并最终延长 健康的跨度。

项目成果

A long and resilient life: the role of coping strategies and variability in their use in lifespan among women.

长寿而有弹性的生活：应对策略的作用及其在女性寿命中的使用变化。

• DOI: 10.1080/10615806.2023.2288333
• 发表时间: 2023
• 期刊: Anxiety, stress, and coping
• 作者: Trudel-Fitzgerald,Claudia;Lee,LewinaO;Guimond,Anne-Josée;Chen,Ruijia;James,Peter;Koga,HayamiK;Lee,HaroldH;Okuzono,SakurakoS;Grodstein,Francine;Rich-Edwards,Janet;Kubzansky,LauraD
• 通讯作者: Kubzansky,LauraD

The Roles of General and Domain-Specific Perceived Stress in Healthy Aging.

一般和特定领域的感知压力在健康老龄化中的作用。

• DOI: 10.1093/geronb/gbab134
• 发表时间: 2022
• 期刊: The journals of gerontology. Series B, Psychological sciences and social sciences
• 作者: Luo,Jing;Zhang,Bo;Willroth,EmilyC;Mroczek,DanielK;Roberts,BrentW
• 通讯作者: Roberts,BrentW

Personality and health: Disentangling their between-person and within-person relationship in three longitudinal studies.

• DOI: 10.1037/pspp0000399
• 发表时间: 2022-03
• 期刊: Journal of personality and social psychology
• 影响因子: 7.6
• 作者: Luo J;Zhang B;Estabrook R;Graham EK;Driver CC;Schalet BD;Turiano NA;Spiro A;Mroczek DK
• 通讯作者: Mroczek DK

Personality Predictors of Emergency Department Post-Discharge Outcomes.

急诊科出院后结果的性格预测因素。

• DOI: 10.5964/ps.7193
• 发表时间: 2021
• 期刊: Personality science
• 作者: Atherton,OliviaE;Willroth,EmilyC;Schwaba,Ted;Goktan,AylaJ;Graham,EileenK;Condon,DavidM;Rao,MiteshB;Mroczek,DanielK
• 通讯作者: Mroczek,DanielK

The Costs of Coping: Long-Term Mortality Risk in Aging Men.

应对成本：老年男性的长期死亡风险。

• DOI: 10.1093/geronb/gbae011
• 发表时间: 2024
• 期刊: The journals of gerontology. Series B, Psychological sciences and social sciences
• 作者: Marino,VictoriaR;Trudel-Fitzgerald,Claudia;Aldwin,CarolynM;Spiro3rd,Avron;Lee,LewinaO
• 通讯作者: Lee,LewinaO