Boston Early Adversity and Mortality Study (BEAMS): Linking administrative data to long-term longitudinal studies

波士顿早期逆境和死亡率研究 (BEAMS)：将行政数据与长期纵向研究联系起来

基本信息

批准号：
10213519
负责人：
Lewina Onyi Lee
金额：
$ 21.78万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10213519
关键词：
Address Adolescent Adult Affect Age Aging Air Area Birth Birth Records Birth Weight Boston Cardiovascular Diseases Censuses Cessation of life Characteristics Child Childhood Chronic Disease Cognitive Data Data Analytics Data Set Data Sources Databases Dementia Dimensions Disabled Persons Disease Elderly Environment Environmental Hazards Exposure to Family Grant Health Hospitals Individual Intervention Knowledge Lead Life Link Location Longevity Longitudinal Studies Mediating Mediator of activation protein Methods Military Personnel Modeling Modification Morbidity - disease rate Municipalities Neighborhoods Non-Insulin-Dependent Diabetes Mellitus Onset of illness Outcome Participant Pathway interactions Personality Traits Persons Policies Poverty Premature Mortality Process Public Health Records Research Design Resources Running Sampling Science Siblings Social support Socioeconomic Status Testing Vital Statistics Water Woman Work adverse childhood events age related arm base cardiometabolic risk cardiometabolism childhood adversity cognitive reserve cohort dementia risk deprivation design digital diverse data early life adversity high risk inner city innovation lead exposure low socioeconomic status male men middle age mortality novel strategies offspring older men older women premature prospective psychosocial socioeconomics stressor therapy design therapy development waterborne young adult

项目摘要

ABSTRACT Adverse childhood experiences, such as poverty, psychosocial stressors, and environmental hazards, have been consistently linked to poor adult health. Despite the public health significance of such early adversity, the processes by which the “long arm of childhood” brings about morbidity and mortality in later life remain largely unknown. Scientific progress in this area has been severely handicapped by two limitations intrinsic to nearly all longitudinal studies of aging: (1) reliance on retrospective assessments of early conditions, and (2) inadequate “lifespan data” on the intervening processes between childhood and old age. The Boston Early Adversity and Mortality Study (BEAMS) will tackle the limitation of retrospective data by using high-quality administrative record linkage. In Aim 1, we link contemporaneous information on early-life health, family, and environmental hazards from multiple databases (including recently digitalized vital and census records, hospital and military records, public data on water- and air-borne lead exposure) to longitudinal data collected on three cohorts of men who have been assessed repeatedly since 1938 (N=724) or 1961 (N=2280) in the greater Boston area. We extend linkage to siblings of the cohorts to include women and allow within-family comparisons. As the cohorts are 74%-94% deceased, record linkage will create an exceptionally rich, cradle- to-death dataset. In Aim 1, we test the hypothesis that early adversities in the psychosocial (e.g., cold or chaotic family environment), socioeconomic (e.g., impoverished neighborhood), and environmental (e.g., lead exposure) domains have independent and additive effects on poor health in older men and women. To address the second limitation noted above, Aim 2 bridges the knowledge gap on processes which transmit the effects of early adversity onto three age-related outcomes: cardiometabolic disease, dementia onset, and all-cause mortality. Leveraging the cradle-to-grave data on these cohorts, we test mediational hypotheses regarding deficiency of socioeconomic (low SES) and psychosocial resources (low social support, extraversion, and conscientiousness), and limited cognitive reserve as candidate pathways. We will examine these mediators as age-specific levels and long-term trajectories in adulthood. We will use a coordinated data analytic approach to inform the replicability and generalizability of findings across the 3 socioeconomically-graded cohorts. Completion of these aims will advance state-of-the-art methods and causal knowledge on how multiple dimensions of early conditions affect lifespan health. Findings are expected to inform policy and intervention efforts targeting the upstream determinants of early adversity, and ultimately prolong the span of good health.

抽象的不利的童年经历，例如贫困，社会心理压力源和环境危害，他一直与成人健康不良联系在一起。尽管这种早期广告具有公共卫生的意义，但 “童年的长臂”带来后来的发病率和死亡率的过程很大程度上仍然很大未知。这一领域的科学进步已被固有的两个局限性严重困扰衰老的所有纵向研究：（1）对早期条件的回顾性评估缓解，以及（2）关于童年与老年之间的中间过程的“寿命数据”不足。波士顿早逆境和死亡率研究（Beams）将通过使用高质量来应对回顾性数据的局限性管理记录链接。在AIM 1中，我们将有关早期健康，家庭和家庭的当代信息联系起来来自多个数据库的环境危害（包括最近数字化生命和人口普查记录，医院和军事记录，关于水和空中铅暴露的公共数据）收集的纵向数据自1938年以来反复评估的三名男子（n = 724）或1961年（n = 2280）大波士顿地区。我们将联系与同伙的兄弟姐妹联系起来，以包括女性并允许家庭内部比较。由于队列已故74％-94％，因此创纪录的联系将创造出异常富裕的摇篮待命数据集。在AIM 1中，我们检验了一个假设，即心理社会中的早期逆境（例如，寒冷或混乱的家庭环境），社会经济（例如，贫困社区）和环境（例如，铅暴露域）领域对老年男女健康的健康不良影响。解决上面指出的第二个限制，aig 2弥合了传递效果的过程的知识差距早期广告与三个与年龄有关的结果：心脏代谢疾病，痴呆发作和全因疾病死亡。利用这些队列上的摇篮到宽度的数据，我们检验有关中介的假设社会经济（低SES）和社会心理资源（社会支持低，外向和外向性和尽职尽责），有限的认知储备作为候选途径。我们将将这些调解人视为成年时代特定年龄的水平和长期轨迹。我们将使用协调的数据分析方法来告知在3个社会经济分级的人群中发现的可复制性和普遍性。这些目标的完成将提高最新方法和因果知识早期条件的维度会影响寿命健康。期望发现将为政策和干预提供信息针对早期广告上游决定者的努力，并最终延长了身体健康的跨度。