Anxiety, Stressful Life Events, and Physical Health in Older Adults

老年人的焦虑、压力生活事件和身体健康

• 批准号: 7409822
• 负责人: Lewina Onyi Lee
• 金额: $ 3.91万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7409822
• 关键词: Address; Adoption; Adult; Affect; Age; Aging; Anxiety; Anxiety Disorders; Attention; Biometry; Cause of Death; Cessation of life; Condition; Data; Data Reporting; Diagnosis; Elderly; Environment; Equation; Event; Expectancy; Fellowship; Frequencies; Genetic; Growth; Half-Life; Health; Healthcare; Healthy People 2010; High Prevalence; Hospitalization; Impaired cognition; Impairment; Individual; Inpatients; Institutes; Intervention; Knowledge; Lead; Life; Light; Literature; Mediator of activation protein; Mental Health; Methodology; Modeling; Mood Disorders; Morbidity - disease rate; Names; Outcome; Participant; Patient Self-Report; Personal Satisfaction; Pharmaceutical Preparations; Population; Prevention; Process; Quality of life; Questionnaires; Records; Registries; Relative (related person); Research; Research Priority; Risk; Role; Sampling; Score; Standards of Weights and Measures; Stressful Event; Suicide; Survival Analysis; Sweden; Symptoms; Testing; Twin Multiple Birth; Twin Studies; age group; age related; base; cost; disability; health care service utilization; health disparity; improved; mortality; service utilization

DESCRIPTION (provided by applicant): The broad objective of the proposed project is to understand the association of anxiety, stressful life events (SLE), and physical health in late life. Little research has been conducted on anxiety in older adults, although anxiety disorders are more prevalent than affective disorders in this age group. Among adults, anxiety is associated with high prevalence of illness, disability, excessive health care usage and poor quality of life. Less is known about the impact of anxiety on the physical health of older adults. The proposed research aims at (1) understanding the temporal association of anxiety, SLE, and physical illness in late life; (2) testing whether anxiety and SLE increase the risk of death in older adults; and (3) understanding genetic and environmental influences underlying these processes. The study will draw from a sample of reared-apart and reared-together twins from a large scale population twin registry. Self-report data on anxiety, SLE and physical health were collected through questionnaires at 8 occasions over a 20-year period; linkage to national registries will further provide data on hospitalization records and mortality. Temporal association will be examined with latent difference score (LDS) structural equation models. Compared to the commonly used cross-lagged or growth curve models, LDS models allow us to evaluate whether increases in (versus mean levels of) anxiety and SLE are predictive of later onset of physical illness, and vice versa. Calculation of mortality risk due to anxiety and stressful life events after adjusting for potential covariates will be performed with survival analysis. Analyses will be performed at both phenotypic and genotypic levels to estimate the effects of anxiety and SLE on illness and mortality after partialling genetic influences. This project directly addresses the research priorities stated by the National Institute on Aging and the Healthy People 2010 initiative: understanding late-life anxiety and its impact on morbidity and mortality are necessarily to improve prevention, diagnosis and intervention of these comorbid conditions. Prevention, diagnosis and intervention efforts can in turn prolong active life and health expectancies in older adults, and reduce unnecessarily costs due to excessive service utilization, medications and impairment in the later half of life.

描述（由申请人提供）：拟议项目的广泛目标是了解焦虑，压力性生活事件（SLE）和后期身体健康的关联。关于老年人焦虑的研究很少，尽管焦虑症比该年龄段的情感障碍更为普​​遍。在成年人中，焦虑与疾病，残疾，过度医疗保健使用率和生活质量差有关。关于焦虑对老年人身体健康的影响知之甚少。拟议的研究旨在（1）了解后期焦虑，SLE和身体疾病的时间关联； （2）测试焦虑和SLE是否会增加老年人死亡的风险； （3）了解这些过程的遗传和环境影响。这项研究将从大规模人口登记册中的饲养和养育双胞胎样本中汲取灵感。关于焦虑，SLE和身体健康的自我报告数据是在20年的8次中通过问卷收集的；与国家注册表的联系将进一步提供有关住院记录和死亡率的数据。时间关联将使用潜在差异评分（LDS）结构方程模型进行检查。与常用的交叉滞后或生长曲线模型相比，LDS模型使我们能够评估焦虑和SLE的增加（相对于平均水平）和SLE是否可以预测身体疾病后来的发作，反之亦然。在调整潜在协变量后，由于焦虑和压力的生活事件而导致的死亡率风险将通过生存分析进行。分析将在表型和基因型水平上进行，以估计焦虑和SLE对疾病和死亡的影响 部分遗传影响。该项目直接解决了国家国家规定的研究优先事项 衰老与健康人民学院2010年倡议：了解后期焦虑及其对 发病率和死亡率必须改善这些合并症的预防，诊断和干预 状况。预防，诊断和干预工作可以延长积极的寿命和健康 老年人的期望，并因服务过多而降低不必要的成本， 生命后期的药物和损害。