Anxiety, Stressful Life Events, and Physical Health in Older Adults

老年人的焦虑、压力生活事件和身体健康

• 批准号: 7409822
• 负责人: Lewina Onyi Lee
• 金额: $ 3.91万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7409822
• 关键词: Address; Adoption; Adult; Affect; Age; Aging; Anxiety; Anxiety Disorders; Attention; Biometry; Cause of Death; Cessation of life; Condition; Data; Data Reporting; Diagnosis; Elderly; Environment; Equation; Event; Expectancy; Fellowship; Frequencies; Genetic; Growth; Half-Life; Health; Healthcare; Healthy People 2010; High Prevalence; Hospitalization; Impaired cognition; Impairment; Individual; Inpatients; Institutes; Intervention; Knowledge; Lead; Life; Light; Literature; Mediator of activation protein; Mental Health; Methodology; Modeling; Mood Disorders; Morbidity - disease rate; Names; Outcome; Participant; Patient Self-Report; Personal Satisfaction; Pharmaceutical Preparations; Population; Prevention; Process; Quality of life; Questionnaires; Records; Registries; Relative (related person); Research; Research Priority; Risk; Role; Sampling; Score; Standards of Weights and Measures; Stressful Event; Suicide; Survival Analysis; Sweden; Symptoms; Testing; Twin Multiple Birth; Twin Studies; age group; age related; base; cost; disability; health care service utilization; health disparity; improved; mortality; service utilization

DESCRIPTION (provided by applicant): The broad objective of the proposed project is to understand the association of anxiety, stressful life events (SLE), and physical health in late life. Little research has been conducted on anxiety in older adults, although anxiety disorders are more prevalent than affective disorders in this age group. Among adults, anxiety is associated with high prevalence of illness, disability, excessive health care usage and poor quality of life. Less is known about the impact of anxiety on the physical health of older adults. The proposed research aims at (1) understanding the temporal association of anxiety, SLE, and physical illness in late life; (2) testing whether anxiety and SLE increase the risk of death in older adults; and (3) understanding genetic and environmental influences underlying these processes. The study will draw from a sample of reared-apart and reared-together twins from a large scale population twin registry. Self-report data on anxiety, SLE and physical health were collected through questionnaires at 8 occasions over a 20-year period; linkage to national registries will further provide data on hospitalization records and mortality. Temporal association will be examined with latent difference score (LDS) structural equation models. Compared to the commonly used cross-lagged or growth curve models, LDS models allow us to evaluate whether increases in (versus mean levels of) anxiety and SLE are predictive of later onset of physical illness, and vice versa. Calculation of mortality risk due to anxiety and stressful life events after adjusting for potential covariates will be performed with survival analysis. Analyses will be performed at both phenotypic and genotypic levels to estimate the effects of anxiety and SLE on illness and mortality after partialling genetic influences. This project directly addresses the research priorities stated by the National Institute on Aging and the Healthy People 2010 initiative: understanding late-life anxiety and its impact on morbidity and mortality are necessarily to improve prevention, diagnosis and intervention of these comorbid conditions. Prevention, diagnosis and intervention efforts can in turn prolong active life and health expectancies in older adults, and reduce unnecessarily costs due to excessive service utilization, medications and impairment in the later half of life.

描述（由申请人提供）：拟议项目的总体目标是了解焦虑、压力生活事件 (SLE) 和晚年身体健康之间的关系。尽管焦虑症在这个年龄段比情感障碍更普遍，但对老年人焦虑的研究很少。在成年人中，焦虑与高患病率、残疾、过度使用医疗保健和生活质量差有关。人们对焦虑对老年人身体健康的影响知之甚少。拟议的研究旨在 (1) 了解晚年焦虑、系统性红斑狼疮和身体疾病之间的时间关联； (2) 测试焦虑和系统性红斑狼疮是否会增加老年人的死亡风险； (3) 了解这些过程背后的遗传和环境影响。该研究将从大规模双胞胎登记处的分开抚养和共同抚养的双胞胎样本中抽取。 20 年间，通过 8 次问卷调查收集了有关焦虑、SLE 和身体健康的自我报告数据；与国家登记处的联系将进一步提供有关住院记录和死亡率的数据。将使用潜在差异评分 (LDS) 结构方程模型检查时间关联。与常用的交叉滞后或生长曲线模型相比，LDS 模型使我们能够评估焦虑和 SLE 的增加（相对于平均水平）是否可以预测身体疾病的后期发作，反之亦然。调整潜在协变量后，将通过生存分析来计算由于焦虑和压力生活事件导致的死亡风险。将在表型和基因型水平上进行分析，以估计焦虑和 SLE 对疾病和死亡率的影响。 偏向遗传影响。该项目直接涉及国家规定的研究重点 老龄化与健康人群研究所 2010 年倡议：了解晚年焦虑及其对健康的影响 发病率和死亡率有必要改善这些共病的预防、诊断和干预 状况。预防、诊断和干预工作反过来可以延长积极的生命和健康 老年人的期望，并减少由于过度使用服务而产生的不必要的成本， 药物治疗和后半生的损伤。