Sleep disturbance and inflammation as determinants of social cognition and behavior: An intensive longitudinal study of adults with schizophrenia-spectrum disorders (NIH Supplemental)

睡眠障碍和炎症作为社会认知和行为的决定因素：对患有精神分裂症谱系障碍的成年人进行的深入纵向研究（NIH 补充）

• 批准号: 10792235
• 负责人: Kelsey A. Bonfils
• 金额: $ 21.96万
• 依托单位: UNIVERSITY OF SOUTHERN MISSISSIPPI
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-15 至 2025-06-14
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10792235
• 关键词: Acute; Address; Adult; Aftercare; Area; Award; Blood; C-reactive protein; Cognitive; Cognitive deficits; Complement; Computer software; Country; Data; Data Sources; Dryness; Ecological momentary assessment; Education; Financial Support; Funding; Future; Goals; Inflammation; Inflammatory; Interleukin-6; Intervention; Investigation; Knowledge; Light; Link; Longitudinal Studies; Measurement; Measures; Mentors; Mentorship; Methods; Mississippi; National Institute of Mental Health; Outcome; Parents; Participant; Patient Self-Report; Perception; Persons; Pittsburgh Sleep Quality Index; Positioning Attribute; Psychology; Qualitative Research; Quality of life; Reporting; Research; Resources; Sampling; Schizophrenia; Schools; Sleep; Sleep disturbances; Social Behavior; Social Functioning; Social outcome; Spottings; Strategic Planning; Students; Symptoms; TNF gene; Testing; Time; Training; Travel; United States National Institutes of Health; Universities; Work; actigraphy; cytokine; deficit syndrome; depressive symptoms; equity, diversity, and inclusion; experience; functional improvement; functional outcomes; graduate student; improved; inflammatory marker; interest; multimodal data; multimodality; novel; phenomenological models; poor sleep; programs; schizophrenia spectrum disorder; severe mental illness; social; social cognition; social determinants; student training; symposium; therapy development; tool; training opportunity; undergraduate student

ABSTRACT People with schizophrenia-spectrum disorders (SSDs) experience deficits in social cognition, which contribute to real-world functional outcomes. As such, social cognition is an important treatment target in SSDs. Yet, current research has not adequately focused on determinants of social cognition, and intervention efforts do not reliably improve functional outcomes or produce durable gains. The parent study associated with this supplement application (1 R15 MH129814-01) aims to address this gap by examining sleep disturbance and inflammation as novel determinants of social cognition in people with SSDs. This supplement application will scientifically extend the parent award in two keys. First, in addition to inflammatory markers including C-reactive protein (CRP) and interleukin-6 (IL-6), this supplement will fund analysis of tumor necrosis factor-alpha (TNF-α). TNF-α is a proinflammatory cytokine that is heightened in people with SSDs, both during acute illness and after treatment, and linked to important outcomes such as depressive symptoms, cognitive deficits, and functioning and quality of life. Especially in light of the link between TNF-α and negative symptoms, it is an important area of investigation with regard to social cognition for those with schizophrenia. Second, this supplement would expand the multi- modal approach of the parent study to include qualitative inquiry. Several qualitative investigations of sleep have been undertaken in samples of people with serious mental illnesses, including schizophrenia. Yet, no study to date has specifically focused on participants’ perceptions of the impact of their sleep on social and other functional outcomes; thus, work is needed in this realm to complement our knowledge from quantitative studies and build depth in our understanding of participants’ perceptions of the detrimental impacts of disturbed sleep. This will be particularly important for future intervention development targeted to improve social outcomes. Together, these aims extend our ability to examine inflammation and incorporate participant perspectives into our understanding of the relationship between sleep and social outcomes for people with SSDs. Thus, impact of the parent study’s results will be increased and better contextualized, while staying within the scope of the original award. In addition to scientific extensions, this supplement will significantly expand the training footprint of the parent award and increase impact for students from diverse and/or underrepresented backgrounds in the School of Psychology at the University of Southern Mississippi. This will be achieved by increasing availability of training opportunities in qualitative research and access to appropriate tools (e.g., NVivo software) and providing financial support and close, individualized mentoring for five additional funded students from diverse and/or underrepresented backgrounds. These aims are consistent both with the goals of the notice of special interest regarding excellence in diversity, equity, inclusion, and accessibility (DEIA) mentorship (NOT-OD-23-002) and the parent award, which is funded by the Research Enhancement Award Program (REAP).

抽象的 患有精神分裂症谱系障碍 (SSD) 的人会出现社会认知缺陷，这会导致 因此，社会认知是当前 SSD 的一个重要治疗目标。 研究没有充分关注社会认知的决定因素，干预措施也没有可靠地 改善功能结果或产生持久的收益与此补充剂相关。 应用程序（1 R15 MH129814-01）旨在通过检查睡眠障碍和炎症来解决这一差距 作为SSD患者社会认知的新决定因素，该补充应用程序将科学地。 延长家长奖有两个重点：首先，除了炎症标志物，包括C反应蛋白（CRP）。 和白介素-6 (IL-6)，该补充品将资助肿瘤坏死因子-α (TNF-α) 的分析。 促炎性细胞因子，即 SSD 患者的哮喘，无论是在急性疾病期间还是在治疗后， 并与抑郁症状、认知缺陷以及功能和质量等重要结果相关 特别是考虑到 TNF-α 与阴性症状之间的联系，这是一个重要的研究领域。 其次，这种补充剂将扩大精神分裂症患者的社会认知。 家长研究的模式方法包括对睡眠的几项定性调查。 对患有严重精神疾病（包括精神分裂症）的人的样本进​​行了研究，但尚无研究表明。 date 特别关注参与者对其睡眠对社交和其他方面影响的看法 因此，需要在这一领域开展工作来补充我们从定量研究中获得的知识 加深我们对参与者对睡眠障碍不利影响的看法的理解。 这对于未来旨在改善社会成果的干预措施的发展尤为重要。 总之，这些目标扩展了我们检查炎症并将参与者的观点纳入其中的能力 我们对 SSD 患者睡眠与社交结果之间关系的理解。 家长研究的结果将得到增加并更好地结合实际，同时保持在原始范围内 除了科学扩展之外，该补充品还将显着扩大该项目的培训范围。 家长奖励并增加对学校中来自不同背景和/或代表性不足的学生的影响 南密西西比大学心理学系将通过增加培训的可用性来实现这一目标。 定性研究和获得适当工具（例如 NVivo 软件）的机会以及提供财务 为另外五名来自不同和/或不同国家的受资助学生提供支持和密切、个性化的指导 这些目标与特殊利益通知的目标一致。 关于卓越的多样性、公平性、包容性和可及性 (DEIA) 指导 (NOT-OD-23-002) 以及 家长奖，由研究增强奖计划（REAP）资助。