Sleep disturbance and inflammation as determinants of social cognition and behavior: An intensive longitudinal study of adults with schizophrenia-spectrum disorders

睡眠障碍和炎症作为社会认知和行为的决定因素：对患有精神分裂症谱系障碍的成年人进行的深入纵向研究

• 批准号: 10438972
• 负责人: Kelsey A. Bonfils
• 金额: $ 44.38万
• 依托单位: UNIVERSITY OF SOUTHERN MISSISSIPPI
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-15 至 2025-06-14
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10438972
• 关键词: Activities of Daily Living; Address; Adult; Age; Award; Behavior; Behavioral; Biological; Bipolar Disorder; Blood; C-reactive protein; Clinical; Clinical Psychology; Cognitive; Cognitive deficits; Collection; Complex; Data; Data Collection; Doctor of Philosophy; Ecological momentary assessment; Environment; Etiology; Exhibits; Exposure to; Future; Health; Impairment; Individual; Inflammation; Influentials; Infrastructure; Interleukin-6; Intervention; Link; Literature; Longitudinal Studies; Measures; Mediating; Mental disorders; Methodology; Methods; Mississippi; National Institute of Mental Health; Neurocognition; Neurocognitive; Outcome; Participant; Patient Self-Report; Persons; Population; Prevalence; Prevention; Process; Quality of life; Research; Research Methodology; Severities; Sleep; Sleep disturbances; Social Behavior; Social Functioning; Spottings; Strategic Planning; Students; Suicide attempt; Surveys; Testing; Time; Universities; Variant; Work; actigraphy; biobehavior; cognitive ability; cognitive testing; endophenotype; experience; experimental study; functional outcomes; graduate student; improved; mental training; multimodality; novel; programs; recruit; schizophrenia-spectrum disorder; severe mental illness; social; social cognition; social determinants; social skills; suicidal risk; symptomatology; training opportunity; undergraduate student

ABSTRACT People with schizophrenia-spectrum disorders (SSDs) experience significant deficits in social cognition. Social cognition independently contributes to real-world outcomes, including social competence and social functioning. As such, social cognition is an important treatment target in SSDs. Yet, current research has not adequately focused on determinants of social cognition, and intervention efforts do not reliably improve functional outcomes or produce durable gains. This study addresses that gap by examining sleep disturbance and inflammation as novel determinants of social cognition in people with SSDs. Up to 80% of people with SSDs experience sleep disturbance, which is linked to increased symptomatology, risk for suicide attempts, and reduced functional capacities and quality of life. Sleep disturbance is also linked to heightened inflammation in those with SSDs and other severe mental illnesses, like bipolar disorders (BDs), including increased C-reactive protein (CRP) and interleukin (IL)-6. Inflammation is elevated in people with SSDs and BDs, and experimental studies in healthy groups show that increased inflammation causes reduced social behavior and social cognition. While a small body of literature links sleep disturbance and inflammation to neurocognitive domains in SSDs, the relationships between sleep disturbance, inflammation, and social cognition are unexplored. This study will use an intensive longitudinal approach to 1) test the relationships between sleep disturbance, inflammation, and social cognition and behavior in those with SSDs, BDs, and healthy control (HC) participants; 2) compare SSD, BD, and HC participants on social cognition, inflammation, and ecologically assessed sleep and social parameters; and 3) develop methods to ecologically assess social cognition and use those methods to explore stability of social cognition as a day-to-day process. Twenty-five participants will be recruited per group (N=75) and asked to wear actigraphs and complete daily surveys (7 per day) over a period of 14 days, followed by a comprehensive social cognitive assessment. Dried blood spots will be collected pre- and post-intensive longitudinal data collection to provide inflammation data. Results will inform social cognitive intervention targets for SSDs and BDs (consistent with the NIMH 2020 Strategic Plan) and support a larger, definitive R01 application. Additionally, consistent with the aims of the Research Enhancement Award Program (REAP), this study will provide ample training opportunities for graduate and undergraduate students, tailored to provide exposure to groups with severe mental illnesses and training in social cognitive research methodology, intensive longitudinal assessment of biobehavioral processes, and collection and analysis of inflammation data. This project will significantly improve the research environment at the University of Southern Mississippi and establish infrastructure to support future projects, leading to a lasting positive impact on the research environment and student opportunities in the USM Clinical Psychology PhD Program.

抽象的 患有精神分裂症谱系障碍 (SSD) 的人会出现严重的社会认知缺陷。 社会认知独立地对现实世界的结果做出贡献，包括社会能力和社会能力 发挥作用。因此，社会认知是 SSD 的重要治疗目标。然而，目前的研究尚未 充分关注社会认知的决定因素，干预措施并不能可靠地改善功能 成果或产生持久收益。这项研究通过检查睡眠障碍和 炎症是 SSD 患者社会认知的新决定因素。高达 80% 的人拥有 SSD 经历睡眠障碍，这与症状增加、自杀企图风险增加以及 功能能力和生活质量下降。睡眠障碍也与炎症加剧有关 患有 SSD 和其他严重精神疾病的人，例如双相情感障碍 (BD)，包括 C 反应性增加 蛋白质（CRP）和白细胞介素（IL）-6。患有 SSD 和 BD 的人炎症加剧，并且实验性的 对健康群体的研究表明，炎症增加会导致社会行为和社会认知减少。 虽然一小部分文献将睡眠障碍和炎症与 SSD 中的神经认知领域联系起来， 睡眠障碍、炎症和社会认知之间的关系尚未被探索。这项研究将 使用强化纵向方法 1) 测试睡眠障碍、炎症和疾病之间的关系 SSD、BD 和健康控制 (HC) 参与者的社会认知和行为； 2）比较SSD， BD 和 HC 参与者的社会认知、炎症以及生态评估的睡眠和社交 参数; 3）开发生态评估社会认知的方法并使用这些方法进行探索 社会认知作为日常过程的稳定性。每组将招募 25 名参与者（N=75） 并要求佩戴活动记录仪并在 14 天内完成每日调查（每天 7 次），然后进行 综合社会认知评估。将在强化前和强化后收集干血斑 纵向数据收集以提供炎症数据。结果将告知社会认知干预目标 适用于 SSD 和 BD（与 NIMH 2020 战略计划一致）并支持更大、更明确的 R01 应用。此外，与研究增强奖励计划 (REAP) 的目标一致，本次 研究将为研究生和本科生提供充足的培训机会，量身定制 接触患有严重精神疾病的群体并接受社会认知研究方法的强化培训 生物行为过程的纵向评估以及炎症数据的收集和分析。这 项目将显着改善南密西西比大学的研究环境，并建立 支持未来项目的基础设施，对研究环境和产生持久的积极影响 USM 临床心理学博士课程的学生机会。