Swine Somatic Cell Gene Editing Testing Center

猪体细胞基因编辑检测中心

基本信息

批准号：
10773796
负责人：
JONATHAN A GREEN
金额：
$ 132.98万
依托单位：
UNIVERSITY OF MISSOURI-COLUMBIA
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-12 至 2028-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10773796
关键词：
Address Animal Experiments Animal Model Animal Testing Animals Basic Science Breeding Clinic Collaborations Communication Communities Cryopreservation Data Storage and Retrieval Development Discipline Effectiveness Emerging Technologies Ensure Evaluation Family suidae Fee-for-Service Plans Foundations Funding Future Genes Genetic Genome Goals Housing Human Impact evaluation Income Individual Inflammation Infrastructure Logistics Maintenance Methods Mission Modeling Physiological Procedures Process Production Reagent Reporter Reporting Research Resources Role Safety Services Standardization System Technology Testing Therapeutic Therapeutic Intervention United States National Institutes of Health biosafety level 2 facility clinically relevant cohort comparative efficacy evaluation experience genetic resource genome editing human disease human model immunogenicity in vivo new therapeutic target novel novel therapeutic intervention porcine model preservation programs reduce symptoms somatic cell gene editing testing services therapy duration tool translational therapeutics

项目摘要

PROJECT SUMMARY: OVERALL The overall purpose of this project is to provide services to the somatic cell genome editing community. Those serviced include to 1) produce, import, cryopreserve, and supply swine biomedical models for the somatic cell genome editing research community, 2) evaluate the safety and efficacy of somatic cell genome editing strategies, and 3) determine the therapeutic value, window of opportunity, and duration of therapies. It is anticipated that these services will advance basic research through testing of novel reagents as well as facilitating translation of therapeutic interventions into the clinic. The role of the Genome Editing Coordination Section will be to manage communication and logistics associated with Swine SCGE Center. These responsibilities include reporting to NIH and regulatory agencies when appropriate as well as communicating with Center Users, the Program Steering Committee, and various collaborators. The role of the Genome Editing Resource Section will be to produce, import, cryopreserve, validate, and supply unique swine models. The Resource Section will also maintain breeding colonies and produce cohorts of experimental animals, and it will be responsible for assembly and maintenance of BSL2 facilities for use by the Testing Section. The role of the Genome Editing Testing Section will be to provide novel delivery methods and reagents for the Somatic Cell Genome Editing community. The Genome Editing Testing Section will streamline the testing process while maintaining a comprehensive and rigorous comparative analysis of new genome editing tools and delivery systems. Our group is ideally suited to provide this testing due to our unique composition of individuals that are experienced with pig production, swine biomedical models, operate successful labs that routinely test cutting-edge genome editing technology, and are associated with world-renowned National Swine Resource and Research Center (NSRRC) and the sunsetting Swine Somatic Cell Genome Editing Consortium Large Animal Testing Center.

项目概要：总体该项目的总体目的是为体细胞基因组编辑界提供服务。那些服务包括 1) 生产、进口、冷冻保存和供应猪体细胞生物医学模型基因组编辑研究界，2）评估体细胞基因组编辑的安全性和有效性策略，3) 确定治疗价值、机会窗和治疗持续时间。这是预计这些服务将通过测试新型试剂以及促进治疗干预措施转化为临床。基因组编辑协调的作用该部门将负责管理与猪 SCGE 中心相关的通讯和物流。这些职责包括在适当的时候向 NIH 和监管机构报告以及沟通与中心用户、项目指导委员会和各种合作者一起。基因组的作用编辑资源部分将生产、导入、冷冻保存、验证和提供独特的猪模型。资源部门还将维护繁殖群并生产实验动物群，并且将负责测试部分使用的 BSL2 设施的组装和维护。的作用基因组编辑测试部分将为体细胞提供新颖的递送方法和试剂细胞基因组编辑社区。基因组编辑测试部分将简化测试过程同时保持对新基因组编辑工具的全面和严格的比较分析输送系统。由于我们独特的个人组成，我们的团队非常适合提供此测试在养猪生产、猪生物医学模型方面经验丰富，运营着定期测试的成功实验室尖端基因组编辑技术，并与世界知名的国家猪资源中心联动和研究中心 (NSRRC) 以及正在衰落的猪体细胞基因组编辑联盟大型动物测试中心。