Environmental Contaminants and Reproductive Health of Akwesasne Mohawk Women

阿克维萨斯尼莫霍克族妇女的环境污染物和生殖健康

• 批准号: 7684444
• 负责人: LAWRENCE M SCHELL
• 金额: $ 50.53万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT ALBANY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-04 至 2013-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7684444
• 关键词: Age-Years; Back; Blood; Characteristics; Cities; Collection; Communities; Data; Diet; Endocrine disruption; Enrollment; Environmental Pollution; Exposure to; Growth; Lead; Life; Measures; Menstrual cycle; Mohawk Indian; Pituitary Gland; Polychlorinated Biphenyls; Property; Questionnaires; Reproductive Health; Risk; Saliva; Sampling; Structure-Activity Relationship; Techniques; Testing; Universities; Urine; Woman; density; diaries; gonad function; health disparity; innovation; minority health; pollutant; reproductive; superfund site; toxicant

The project led by Drs. Schell and Carpenter, entitled "Environmental contaminants and reproductive health of Akwesasne Mohawk women" builds on a collaborative relationship between the Akwesasne Mohawk Nation and the University at Albany reaching back some 20 years, while also representing an expansion of the Center's focus to the region beyond Albany and Amsterdam. The study's objective is to determine the effect of exposure to PCBs, other persistent organic pollutants and lead on characteristics of the menstrual cycle among Mohawk women who are between 20 and 35 years of age and living in Akwesasne, which is adjacent to a federal and two state Superfund sites. The study will enroll 180 women who will be followed through one menstrual cycle with collection of blood, urine and daily saliva samples to investigate the relationship of PCB congeners and other toxicants to gonadal function, pituitary function and other characteristics of the menstrual cycle measured through diaries and questionnaires. This study has several innovative methodological features: the simultaneous consideration of multiple toxicants with endocrine disrupting properties, the congener specific analysis of PCBs for testing structure-function relationships with regard to reproductive effects, the consideration of these effects within the context of other common influences on reproductive parameters, and the application of statistical techniques and growth curve analyses that take full advantage of the density of data obtained throughout the cycle. The project is equally notable for its meaning and salience to the community. Activities that express and reaffirm Mohawk identity and culture may increase exposure to local contaminants such as PCBs, particularly through diet. The findings of this study will have great significance not only for the promotion of good reproductive health (critical to the survival of the nation as a culture and a people) but also for understanding the risk possibly related to activities that have been traditionally associated with Mohawk ways of life.

该项目由Drs领导。 Schell和Carpenter，名为“环境污染物和生殖健康 Akwesasne Mohawk的妇女“建立在Akwesasne Mohawk之间的合作关系的基础上 国家和奥尔巴尼的大学回到了20年，同时也代表 该中心集中于奥尔巴尼和阿姆斯特丹以外的地区。该研究的目标是确定 暴露于PCB的影响，其他持续的有机污染物以及月经特征的影响 在20至35岁之间且住在阿克维萨斯（Akwesasne）的莫霍克族妇女中的周期 毗邻联邦和两个州超级基金站点。这项研究将招募180名妇女 通过一个月经周期，收集血液，尿液和每日唾液样本，调查 PCB同类物和其他有毒物质与性腺功能，垂体功能和其他关系的关系 通过日记和问卷测量月经周期的特征。这项研究有几个 创新的方法论特征：同时考虑多种毒物的内分泌 破坏特性，同类物的特定于PCB的特定分析，用于测试结构功能与与 考虑到生殖作用，在其他共同的背景下考虑这些效果 对生殖参数的影响以及统计技术和生长曲线的应用 分析充分利用了整个周期中获得的数据密度。该项目同样 以其对社区的意义和显着性而闻名。表达和重申莫霍克身份的活动 培养可能会增加对当地污染物（例如PCB）的接触，尤其是通过饮食。这 这项研究的结果不仅对促进良好的生殖健康具有重要意义 （对国家作为一种文化和人民的生存至关重要），也可能了解风险 与传统上与莫霍克族生活方式相关的活动有关。