Environmental Contaminants and Reproductive Health of Akwesasne Mohawk Women

阿克维萨斯尼莫霍克族妇女的环境污染物和生殖健康

• 批准号: 8374797
• 负责人: LAWRENCE M SCHELL
• 金额: $ 46.56万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT ALBANY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-01-11 至 2013-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8374797
• 关键词: Aborigine; Address; Adult; Affect; Age; Age-Years; Animals; Antibodies; Assimilations; Autoimmune Diseases; Back; Blood; Body Burden; Body Composition; Characteristics; Cities; Collaborations; Collection; Communities; Complex; Data; Demographic Factors; Dichlorodiphenyl Dichloroethylene; Diet; Disasters; Economic Factors; Endocrine Disruptors; Endocrine disruption; Enrollment; Environment; Environmental Pollutants; Environmental Pollution; Estradiol; Exposure to; Female; Fertility; Follicle Stimulating Hormone; Food; Gonadotropins; Growth; Health; Hexachlorobenzene; Human; Individual; Industry; Laboratory Study; Lead; Life; Luteinizing Hormone; Mammals; Measures; Menstrual cycle; Methodology; Methods; Minority; Mirex; Mohawk Indian; Needs Assessment; Overweight; Personal Satisfaction; Phase; Physical activity; Physical environment; Pituitary Gland; Political Factor; Pollution; Polychlorinated Biphenyls; Population; Predisposition; Progesterone; Property; Public Health; Questionnaires; Recruitment Activity; Religion and Spirituality; Reporting; Reproduction; Reproductive Health; Reproductive system; Research; Risk; Rivers; Role; Saliva; Sampling; Sexual Development; Shapes; Site; Source; Steroids; Structure-Activity Relationship; System; Techniques; Testing; Thyroid Function Tests; Thyrotropin; Thyroxine; Toxic Environmental Substances; Triiodothyronine; Universities; Urine; Woman; density; diaries; gonad function; health disparity; indexing; innovation; lifestyle factors; minority health; neurobehavioral; pollutant; pressure; reproductive; reproductive function; steroid hormone; superfund site; toxicant

The project led by Drs. Schell and Carpenter, entitled "Environmental contaminants and reproductive health of Akwesasne Mohawk women" builds on a collaborative relationship between the Akwesasne Mohawk Nation and the University at Albany reaching back some 20 years, while also representing an expansion of the Center's focus to the region beyond Albany and Amsterdam. The study's objective is to determine the effect of exposure to PCBs, other persistent organic pollutants and lead on characteristics of the menstrual cycle among Mohawk women who are between 20 and 35 years of age and living in Akwesasne, which is adjacent to a federal and two state Superfund sites. The study will enroll 180 women who will be followed through one menstrual cycle with collection of blood, urine and daily saliva samples to investigate the relationship of PCB congeners and other toxicants to gonadal function, pituitary function and other characteristics of the menstrual cycle measured through diaries and questionnaires. This study has several innovative methodological features: the simultaneous consideration of multiple toxicants with endocrine disrupting properties, the congener specific analysis of PCBs for testing structure-function relationships with regard to reproductive effects, the consideration of these effects within the context of other common influences on reproductive parameters, and the application of statistical techniques and growth curve analyses that take full advantage of the density of data obtained throughout the cycle. The project is equally notable for its meaning and salience to the community. Activities that express and reaffirm Mohawk identity and culture may increase exposure to local contaminants such as PCBs, particularly through diet. The findings of this study will have great significance not only for the promotion of good reproductive health (critical to the survival of the nation as a culture and a people) but also for understanding the risk possibly related to activities that have been traditionally associated with Mohawk ways of life. Considerable concern exists over possible effects of endocrine disrupting compounds such as polychlorinated biphenyls (PCBs) and lead (Pb) on human reproductive health. Effects on mammalian reproduction are known, but evidence regarding non-occupational exposure to environmental toxicants on parameters related to human fertility is lacking. Reproductive health is of great concern to the Akwesasne Mohawk Nation which is located on the St. Lawrence River. Like many minority communities, Akwesasne is located near a site of major environmental contamination: it is adjacent to a federal and two state Superfund sites. Important local food sources are contaminated, and exposure is perceived as a threat to the community already under pressure of assimilation and dispersal. Good reproductive health is seen as essential to the survival of the nation as a culture and a people. The project builds on a 12 year collaborative relationship between the Akwesasne Mohawk Nation and the University at Albany. This study aims to determine the effects of PCBs, other persistent organic pollutants, and lead (understudied for its endocrine disrupting properties) on characteristics of the menstrual cycle among Mohawk women between the ages of 20 and 35. It will follow 180 women through one menstrual cycle collecting blood, urine and daily saliva samples to investigate the relationship of PCB congeners and other toxicants to: 1) gonadal function as indexed by steroid estradiol and progesterone levels throught the cycle measured in saliva, 2) pituitary function indexed by gonadotropin levels, and 3) other characteristics of the menstrual cycle reported through diary and questionnaire. The project is innovative in its' simultaneous consideration of multiple toxicants with endocrine disrupting properties, the congener specific analysis of PCBs that allows testing structure-function relationships with regard to reproductive effects and the consideration of these effects within the context of other common influences on reproductive parameters (measures of thyroid function, autoimmune disease, overweight, and of physical activity) using standard statsitical methods and growth curve analyses to take full advantage of the density of data obtained throughout the cycle and which have not been applied before in studies of this matter.

该项目由Drs领导。 Schell和Carpenter的名字为“ Akwesasne Mohawk妇女的环境污染物和生殖健康”建立在Akwesasne Mohawk Nation和Albany大学之间的协作关系上，同时还可以扩展到Albany and Amsterdam以外的该中心的焦点。该研究的目的是确定暴露于PCB，其他持续的有机污染物的影响，并导致20至35岁之间的月经周期的特征，并居住在Akwesasne，该妇女与联邦和两个州超级网站相邻。这项研究将招募180名女性，她们将在一个月经周期中，并收集血液，尿液和每日唾液样本，以研究PCB同类物和其他有毒物质与性腺功能，垂体功能以及通过日益习惯和问卷测量的月经周期的其他特征的关系。这项研究具有几个创新的方法论特征：同时考虑多种毒物具有内分泌干扰性能的多种毒物，对生殖效应的结构功能关系的PCB的特定特定分析，在其他对生殖参数的其他常见影响中对这些效果的考虑，以及对统计技术的应用以及在整个统计技术中的应用，以及在整个统计技术中的应用程序的应用程序，这些效果需要获得完整的cerve curve curve curve curve curve curve curve curve curve curve curve curve curve copter的效果。该项目以其对社区的含义和显着性而引人注目。表达和重申Mohawk的身份和文化的活动可能会增加对PCB等局部污染物的接触，尤其是通过饮食。这项研究的结果不仅对促进良好的生殖健康（对国家作为一种文化和人民的生存至关重要）的意义将具有重要意义。 对于内分泌干扰化合物（例如多氯联苯（PCB））和铅（PB）对人类生殖健康的可能影响，存在相当大的关注。已知对哺乳动物繁殖的影响，但是缺乏有关非占领的环境有毒物质对与人类生育有关的参数的证据。生殖健康非常关注位于圣劳伦斯河上的Akwesasne Mohawk Nation。像许多少数民族社区一样，Akwesasne位于重大环境污染的地点附近：它毗邻联邦和两个州超级基金地点。重要的当地食物来源受到污染，并且接触被视为对已经在已经在压力下的社区的威胁 同化和分散。良好的生殖健康被视为对国家作为一种文化和人民的生存至关重要。该项目建立在Akwesasne Mohawk Nation和Albany大学之间的12年合作关系的基础上。 This study aims to determine the effects of PCBs, other persistent organic pollutants, and lead (understudied for its endocrine disrupting properties) on characteristics of the menstrual cycle among Mohawk women between the ages of 20 and 35. It will follow 180 women through one menstrual cycle collecting blood, urine and daily saliva samples to investigate the relationship of PCB congeners and other toxicants to: 1) gonadal function as通过类固醇雌二醇和孕激素水平在整个周期中索引 在唾液中测量，2）垂体功能由促性腺激素水平索引，以及3）通过日记和问卷报告的月经周期的其他特征。该项目的同时考虑多种毒物具有内分泌干扰性能，对PCB的特定分析，可以测试与生殖效应的结构功能关系的特定分析，并在其他常见影响的背景下对这些效应的考虑对这些效应的考虑，对生殖功能的增长和统计型统计疾病的测量，策略和跨度的效果，策略和策略，以及策划的效果，策划和策略，以及策划，以及策略，以及，以及策略，以及均为型号的效果。分析以充分利用整个周期中获得的数据密度，并且 在研究此事之前没有应用。