Muscular Dystrophy Center Core Laboratories

肌营养不良症中心核心实验室

• 批准号: 7668115
• 负责人: JOHN W DAY
• 金额: $ 60.02万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7668115
• 关键词: Muscular; Dystrophy; Center; Core; Laboratories

DESCRIPTION (provided by applicant): The University of Minnesota Muscular Dystrophy Center (UMN-MDCenter) has grown in scope and breadth since being organized to improve collaboration in basic, clinical and translational investigation of muscle biology and disease. Success of the MDCenter has recently helped recruit several prominent muscle investigators to Minnesota, capitalizing on existing strength to create what is now a unique multifaceted program focused on understanding muscle and treating muscle disease. To maximize interaction, collaboration and productivity of the expanding MDCenter, we are applying for NIAMS Core Center support with the following specific aims: 1) Core B: To strengthen and increase accessibility of a research core that provides clinical specimens to muscle investigators, and uses the CLIA-certified muscle biopsy laboratory to characterize human and animal muscle with comprehensive histological and immunostaining methods. 2) Core C: To strengthen and expand a repository of murine muscular dystrophy models for muscle investigators, which is coupled with the unique ability of our Center to characterize human and animal muscle force generation at molecular, cellular and whole tissue levels. 3) Core A: To provide administrative support for the research cores, and to establish a pilot and feasibility program for new independent investigators, which will strengthen and extend current MDCenter programs for undergraduate, graduate and post-doctoral trainees. 4) To increase institutional, regional and national awareness of UMN-MDCenter and CCMBM to enhance provision of institutional resources commensurate with the potential of this program.

描述（由申请人提供）：明尼苏达大学肌营养不良中心 (UMN-MDCenter) 自从成立以来，其范围和广度不断扩大，旨在改善肌肉生物学和疾病的基础、临床和转化研究方面的合作。 MD中心的成功最近帮助明尼苏达州招募了几位著名的肌肉研究人员，利用现有的实力创建了一个独特的多方面项目，重点是了解肌肉和治疗肌肉疾病。为了最大限度地提高不断扩大的 MD 中心的互动、协作和生产力，我们正在申请 NIAMS 核心中心的支持，其具体目标如下： 1) 核心 B：加强和提高研究核心的可及性，为肌肉研究人员提供临床标本，并使用CLIA 认证的肌肉活检实验室，利用综合组织学和免疫染色方法来表征人类和动物肌肉。 2) 核心 C：为肌肉研究人员加强和扩展小鼠肌营养不良模型库，再加上我们中心在分子、细胞和整个组织水平上表征人类和动物肌肉力量产生的独特能力。 3) 核心A：为研究核心提供行政支持，并为新的独立研究者建立试点和可行性计划，这将加强和扩展现有MDCenter针对本科生、研究生和博士后培训生的项目。 4) 提高机构、区域和国家对 UMN-MDCenter 和 CCMBM 的认识，以加强提供与该计划潜力相称的机构资源。