Genomics Alcohol Research Core

基因组酒精研究核心

• 批准号: 7858949
• 负责人: ROBERT J. HITZEMANN
• 金额: $ 46.2万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7858949
• 关键词: Address; Affect; Alcohol abuse; Alcohol consumption; Alcoholism; Alcohols; Am 80; Animals; Applications Grants; Appointment; Area; Behavioral; Bioinformatics; Biological; Biomedical Research; Biometry; Blood alcohol level measurement; Brain; Center Core Grants; Chronic; Communities; Consumption; Coupled; Data; Development; Drug abuse; Educational process of instructing; Emerging Technologies; Experimental Designs; Faculty; Funding; Gene Expression; Genes; Genetic Models; Genetic Polymorphism; Genomics; Goals; Grant; Individual; Joints; Liver; Macaca mulatta; Medical Genetics; Medical Informatics; Modeling; Molecular; Monkeys; Mus; National Institute on Alcohol Abuse and Alcoholism; Needs Assessment; Network-based; Neurosciences; Oregon; Pancreas; Positioning Attribute; Primates; Problem Solving; Protocols documentation; Quantitative Trait Loci; Recovery; Recruitment Activity; Regulation; Research; Research Personnel; Research Project Grants; Resources; Role; Scientist; Self Administration; Services; Substance abuse problem; System; Techniques; Testing; Tissues; United States National Institutes of Health; Universities; Wages; alcohol exposure; alcohol research; biological systems; brain tissue; clinical epidemiology; interest; medical schools; multidisciplinary; next generation; nonhuman primate; professor; programs; public health relevance; ranpirnase; repository; response; skills

DESCRIPTION (provided by applicant): The following grant application is submitted in response to RFA-OD-09-005 (Recovery Act Limited Competition: Supporting New Faculty Recruitment to Enhance Research Resources through Biomedical Research Core Centers [P30]). We believe that the application is responsive to the RFA In that we seek to hire, provide appropriate start-up packages and develop pilot research projects for newly-independent investigators, with the goal of augmenting and expanding OHSU's community of multidisciplinary researchers focusing on areas of biomedical research relevant to NIH. This P30 focuses on a Bioinformatics Core with the goal of recruiting individual(s) with interests in alcohol and drug abuse coupled with interests in mouse and non-human primate genomics. The emphasis on alcohol and drug abuse aligns with the interests and grant portfolio of the applicant department - Behavioral Neuroscience. Thus, we feel the application is best directed to the National Institute on Alcohol Abuse and Alcoholism (NIAAA). The primary partner in this application, the Oregon National Primate Research Center (ONPRC) supports this alignment; here we note the relatively recent joint hiring (Behavioral Neuroscience and the ONPRC) of Dr Kathy Grant, a leading expert on primate models of alcohol abuse and a collaborator on this application. However, we (Behavioral Neuroscience and the ONPRC) view the indlvidual(s) recruited through the P30 mechanism as also having a larger role in developing bioinformatic resources at OHSU. The bulk of the P30 funding will be used to help recruit junior faculty and to develop a pilot research program. The successful applicant(s) will be appointed as an Assistant Professor in the Department of Behavioral Neuroscience (tenure track) and as a Staff Scientist at the ONPRC, with joint appointments in the Departments of Molecular & Medical Genetics and Medical Informatics and Clinical Epidemiology. The successful applicant(s) for the position within the Core will be individual(s) with expertise in a field we have termed "systems bioinformatics". The intent of using this term is that we will recruit an individual not only with the analytical skills to effectively utilize emerging technologies such as mRNAseq or ChiPseq but also with interests in solving problems related to the Center. PUBLIC HEALTH RELEVANCE: The Core Center supported by the P30 mechanism will be used to recruit new faculty to study from a biological perspective, alcohol abuse and alcoholism. The research will involve initially the use of sophisticated analytical approaches to study gene expression in brain and other tissues affected by chronic alcohol exposure. The goal is to detect the underlying pathological mechanisms.

描述（由申请人提供）：以下拨款申请是为了响应 RFA-OD-09-005（恢复法案有限竞争：支持新教师招聘以通过生物医学研究核心中心增强研究资源 [P30]）而提交的。我们相信该申请是对 RFA 的回应，因为我们寻求雇用、提供适当的启动包并为新独立研究人员开发试点研究项目，其目标是增强和扩大 OHSU 的多学科研究人员社区，重点关注以下领域：与 NIH 相关的生物医学研究。该 P30 重点关注生物信息学核心，目标是招募对酒精和药物滥用感兴趣以及对小鼠和非人类灵长类动物基因组学感兴趣的个人。对酒精和药物滥用的重视符合申请部门——行为神经科学的兴趣和资助组合。因此，我们认为申请最好直接向国家酒精滥用和酒精中毒研究所 (NIAAA) 提出。该应用程序的主要合作伙伴俄勒冈国家灵长类动物研究中心 (ONPRC) 支持这种对齐方式；在这里，我们注意到最近联合聘用了 Kathy Grant 博士（行为神经科学和 ONPRC），她是灵长类动物酗酒模型方面的领先专家，也是该应用程序的合作者。然而，我们（行为神经科学和 ONPRC）认为通过 P30 机制招募的个人在 OHSU 开发生物信息资源方面也发挥着更大的作用。 P30 的大部分资金将用于帮助招聘初级教师和开发试点研究项目。成功的申请人将被任命为行为神经科学系的助理教授（终身教授）和 ONPRC 的职员科学家，并在分子与医学遗传学、医学信息学和临床流行病学系联合任命。核心职位的成功申请人将是在我们称为“系统生物信息学”的领域具有专业知识的个人。使用该术语的目的是，我们将招募不仅具有有效利用 mRNAseq 或 ChiPseq 等新兴技术的分析技能，而且对解决与中心相关问题感兴趣的个人。 公共卫生相关性：P30机制支持的核心中心将用于招募新教师，从生物学角度研究酒精滥用和酗酒。该研究最初将涉及使用复杂的分析方法来研究受长期酒精暴露影响的大脑和其他组织中的基因表达。目标是检测潜在的病理机制。