Population-environment dynamics influencing malaria risk in the Peruvian Amazon

影响秘鲁亚马逊地区疟疾风险的人口环境动态

• 批准号: 7672561
• 负责人: WILLIAM KUANG-YAO PAN
• 金额: $ 13.41万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7672561
• 关键词: Area; Biometry; Camping; Commit; Communities; Data; Deforestation; Development Plans; Ecology; Environment; Epidemiology; Genotype; Goals; Habitats; Health; Household; Human; Image; Knowledge; Larva; Latin America; Malaria; Malaria prevention; Measures; Mentored Research Scientist Development Award; Mentors; Modeling; National Institute of Allergy and Infectious Disease; National Institute of Child Health and Human Development; Pan Genus; Pattern; Peru; Plasmodium; Policies; Population; Population Research; Prevalence; Reading; Research; Research Infrastructure; Research Personnel; Risk; Rivers; Sampling; Series; Surveys; Testing; Time; To specify; Training; Transportation; Water; career development; density; experience; forest; informant; land cover; land use; multilevel analysis; novel; programs; remote sensing; response; skills; vector

DESCRIPTION (provided by applicant): This application is being submitted in response to Notice NOT-HD-01-004, "Expansion of the NICHD Mentored Research Scientist Development Award (K01): Population Research." The objectives of this MRSDA are to expand Dr. William Pan's training and knowledge in the field of population, environment and health dynamics toward the goal of becoming an expert and independent investigator in this growing field. Dr. Pan will build upon his experience and expertise in household and use, biostatistics, multilevel modeling and spatial analysis by obtaining training in remote sensing (RS), ecology (vector ecology and biogeography), and malaria epidemiology. This new set of skills and knowledge will be obtained through a well-defined career development plan consisting of coursework, directed readings, and mentored research. Coursework and readings will be conducted in all areas, with a particular focus on RS and ecology. An expert group of mentors and collaborators have committed themselves to helping Dr. Pan achieve his goal and provide guidance for his proposed Mentored Research. The long-term objectives for his study are: (1) Identify household, community, and infrastructure factors associated with land use and land cover (LULC); and (2) Determine the extent to which LULC, and determinants thereof, are associated with malaria vector presence and human malaria risk towards the eventual control and eradication of P. vivax. The project tests the central hypothesis that community settlement areas have more diverse LULC, less land cleared, and better environmental management than areas managed by nearby labor camps; and therefore, malaria vector density will be greater in areas managed by labor camps than by household settlers. To achieve the objectives and test hypotheses, the study proposes to combine a population-environment and vector ecology study in the northern Peruvian Amazon along the Mazan and Napo Rivers. Data to be combined include survey information from households and key informants in communities and labor camps, locational data of relevant infrastructure and transportation networks, a time series of RS images, and a longitudinal sample of bodies of water to collect malaria vector larvae. Spatially-explicit models using traditional and Bayesian multilevel frameworks will be specified to test hypotheses. The findings from this study will have a wide impact on malaria prevention and control programs throughout Latin America.

描述（由申请人提供）：该申请是为了回应通知NOT-HD-01-004，“扩展NICHD指导研究科学家发展奖（K01）：人口研究”。 MRSDA的目标是将威廉·潘博士在人口，环境和健康动态领域的培训和知识扩展到成为这个不断发展的领域的专家和独立调查员的目标。 Pan博士将通过获得遥感（RS），生态学（Vector Ecology and Biogeography）以及疟疾流行病学的培训来基于他在家庭和使用，生物统计学，多级建模和空间分析方面的经验和专业知识。这套新的技能和知识将通过定义明确的职业发展计划获得，该计划包括课程，定向阅读和指导的研究。课程和读数将在所有领域进行，特别关注RS和生态。一群专家的导师和合作者致力于帮助Pan博士实现自己的目标，并为他拟议的指导研究提供指导。他的研究的长期目标是：（1）确定与土地使用和土地覆盖相关的家庭，社区和基础设施因素（LULC）； （2）确定LULC及其决定因素与疟疾载体的存在和人类疟疾的风险有关最终控制和消除Vivax的风险。该项目检验了一个中心假设，即社区和解地区的多样性多样化，清理土地较少，环境管理比附近劳动营管理的地区更好。因此，劳动营管理的疟疾载体密度将比家庭定居者更大。为了实现目标和检验假设，该研究建议在北部秘鲁亚马逊沿线沿着Mazan和Napo Rivers的北部亚马逊结合种群环境和媒介生态研究。要合并的数据包括来自社区和劳动营的家庭和主要线人的调查信息，相关基础设施和运输网络的位置数据，RS图像的时间序列以及水体的纵向水样本以收集疟疾载体幼虫。将指定使用传统和贝叶斯多级框架的空间解释模型来检验假设。这项研究的发现将对整个拉丁美洲的疟疾预防和控制计划产生广泛影响。