MOLECULAR BIOLOGY AND TISSUE ENGINEERING CORE

分子生物学和组织工程核心

• 批准号: 7715330
• 负责人: KASTURI RANGANNA
• 金额: $ 41.03万
• 依托单位: TEXAS SOUTHERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715330
• 关键词: 3-Dimensional; Arts; Biological Models; Biomedical Research; California; Collaborations; Complex; Computer Retrieval of Information on Scientific Projects Database; Core Facility; County; Cultured Cells; Doctor of Philosophy; Educational workshop; Faculty; Funding; Grant; Hand; Health Sciences; Institution; Journals; Laboratories; Molecular Biology; Oranges; Outcome; Pediatric Hospitals; Pharmacologic Substance; Pharmacy facility; Preparation; Publications; Purpose; Research; Research Activity; Research Infrastructure; Research Personnel; Research Support; Resources; Services; Source; Students; Technology; Tissue Engineering; Tissues; Training; United States National Institutes of Health; Universities; abstracting; college; in vitro Model; instrumentation; interest; planetary Atmosphere; programs; research and development; two-dimensional

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Molecular Biology and Tissue Engineering (MBTE) Core Facility The MBTE core facility consists of two components, Molecular Biology (MB) and Tissue Engineering (TE). The core facility was created at the College of Pharmacy and Health Sciences (COPHS) to support biomedical research activities. The purpose of the MBTE core facility is to maintain and enhance the existing molecular biology and 2-dimensional (2-D) cell culture component (MB); and to develop and establish a new tissue engineering section (TE) component that supports 3-dimensional (3-D) tissue-equivalent cell culture technology to provide biomedical researchers at TSU with state-of-the-art molecular biology and cell culture research infrastructure. The specific aims of the MBTE core facility are to: 1. Continue to provide the technical and hands-on support services in molecular biology and 2- dimensional cell culture, and requisite instrumentation to TSU investigators. 2. Add a new tissue engineering (TE) section to establish a complex 3-D tissue-equivalent in vitro model system and provide technical support services to TSU faculty and graduate students interested in utilizing this technology in their biomedical research. 3. Create a stimulating and supportive scientific atmosphere for the researchers at TSU through research development activities, seminar programs, journal club meetings, and research presentations. 4. Establish collaborative research efforts, and pursue exchange of technical capabilities with investigators at TSU and other research-intensive universities; and by attending technology workshops. In the previous year, the activities of MBTE core facility, through the technical and hands-on research support services, and instrumentation to the research investigators at TSU have resulted in significant outcomes. The facility provided support for a total of 26 projects, which resulted in: 12 abstract presentations; 7 publications; and 5 proposals, of which one is pending, two are not funded and two are in preparation for resubmission. Additionally, the MBTE facility facilitated training and povided research resource support to four pharmaceutical sciencesis MS/PhD students. Furthermore, the MBTE core director and assistant director have established a total of ten collaborations within TSU (Drs. Rambis Chu, Mohammad Newaz, Kasturi Ranganna and Zivar Yousefipour) and outside TSU (Drs. Frank M. Yatsu, UT Health Science Center, Houston, Bruce Hammock, and Christopher Morisseau from University of California, Davis, CA, and Philip Schwartz, Children's Hospital of Orange County, University of California, Irvine, CA, Basalingappa Hungund, Columbia University, NY and Betsy Southerland, Brookhaven National Laboratory, Upton, NY.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 分子生物学和组织工程（MBTE）核心设施 MBTE 核心设施由两个部分组成：分子生物学 (MB) 和组织工程 (TE)。核心设施是在药学与健康科学学院 (COPHS) 创建的，旨在支持生物医学研究活动。 MBTE核心设施的目的是维持和增强现有的分子生物学和二维（2-D）细胞培养成分（MB）；开发和建立新的组织工程部分 (TE) 组件，支持 3 维 (3-D) 组织等效细胞培养技术，为 TSU 的生物医学研究人员提供最先进的分子生物学和细胞培养研究基础设施。 MBTE 核心设施的具体目标是： 1. 继续为 TSU 研究人员提供分子生物学和二维细胞培养方面的技术和实践支持服务以及必要的仪器。 2. 增加新的组织工程（TE）部分，以建立复杂的3D组织等效体外模型系统，并为有兴趣在生物医学研究中利用该技术的 TSU 教师和研究生提供技术支持服务。 3. 通过研究开发活动、研讨会项目、期刊俱乐部会议和研究报告，为托国立大学的研究人员创造一个激励和支持性的科学氛围。 4. 建立合作研究工作，并与托国立大学和其他研究密集型大学的研究人员进行技术能力交流；并参加技术研讨会。 去年，MBTE 核心设施的活动通过为 TSU 的研究人员提供技术和实践研究支持服务以及仪器，取得了重大成果。该设施为总共 26 个项目提供了支持，最终产生了： 12 个摘要演示； 7 种出版物； 5 项提案，其中一项待决，两项尚未资助，两项正在准备重新提交。此外，MBTE 设施还为四名药物科学硕士/博士生提供了培训并提供研究资源支持。 此外，MBTE 核心主任和助理主任在 TSU 内部（Rambis Chu 博士、Mohammad Newaz、Kasturi Ranganna 和 Zivar Yousefipour 博士）和 TSU 外部（休斯顿 UT 健康科学中心 Frank M. Yatsu 博士）建立了总共十项合作，来自加州大学戴维斯分校的 Bruce Hammock 和 Christopher Morisseau，以及加州大学欧文分校奥兰治县儿童医院的 Philip Schwartz，纽约哥伦比亚大学的 Basalingappa Hungund 和纽约州厄普顿布鲁克海文国家实验室的 Betsy Southerland。