OZONE DOSE TO THE HUMAN RESPIRATORY TRACT: THE EFFECTS OF CIGARETT SMOKING

臭氧对人体呼吸道的剂量：吸烟的影响

• 批准号: 7378528
• 负责人: James S Ultman
• 金额: $ 6.11万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378528
• 关键词: OZONE; DOSE; HUMAN; RESPIRATORY; TRACT

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We previously developed a continuous inhalation method that measures the overall dose of O3 to an intact human lung, and a bolus inhalation method that characterizes the relative uptake of O3 into different regions of the respiratory tract. In the current student, we will apply these methods to healthy smokers and nonsmokers to determine how smoking influences O3 uptake into the conducting airways compared to O3 uptake into the alveolated airspaces. The physiological responses of the conducting airways and respiratory airspaces will also be measured so that regional dose-response relationships can be determined. We will utilize 30 healthy smokers and 30 healthy nonsmokers who each participate in three research sessions. During session I, the distribution of O3 uptake will be measured by the bolus inhalation method while employing a standard breathing pattern. During session II, overall O3 uptake will be measured on a breath-by-breath basis while a subject continuously breathes 0.30 ppm O3 while exercising on a cycle ergometer. During session III, intended to be a control study, each subject will exercise for one hour while breathing clean air. Physiological responses in sessions II and III will be determined from decrements in FEV1 as well as from the peripheral airspace area (AP) obtained from a CO2 expirogram.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。我们先前开发了一种连续吸入方法，该方法可测量O3对完整的人肺的总剂量，以及一种推注吸入方法，该方法表征O3相对吸收到呼吸道不同区域。在目前的学生中，我们将把这些方法应用于健康的吸烟者和非吸烟者，以确定吸烟如何影响O3对导电通风的吸收，而O3吸收了流动气球空间。还将测量导电通风道和呼吸空间的生理反应，以便可以确定区域剂量反应关系。 我们将利用30名健康吸烟者和30位健康的不吸烟者参加三个研究课程。在第I期中，使用标准呼吸模式时，将通过推注吸入法测量O3摄取的分布。在第二会议期间，总体O3吸收将以呼吸呼吸的基础测量，而受试者在循环测量器上进行锻炼时连续呼吸0.30 ppm O3。在第三节期间，旨在作为对照研究，每个受试者在呼吸干净的空气时将锻炼一小时。会议II和III中的生理反应将取决于FEV1的减少以及从CO2期刊获得的外围空域区域（AP）确定。