International Retroviral Symposium: Assembly, Maturation and Uncoating

国际逆转录病毒研讨会：组装、成熟和脱壳

基本信息

批准号：
10762858
负责人：
Saveez Saffarian
金额：
$ 2.5万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-14 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10762858
关键词：
Acquired Immunodeficiency Syndrome Antiviral Agents Area Australia Binding Biochemical Biochemistry Bioinformatics Biophysical Process Biophysics Boston Cells Chromosomes Collaborations Complex Country Development Discipline Disease Ensure Environment Enzymes Europe Exposure to Female Funding Genome Goals HIV-1 Human Infection Integrase International International Cooperation Life Cycle Stages Location Malignant Neoplasms Membrane Mentors Microscopy Nature Nucleocapsid Proteins Outcome Participant Persons Postdoctoral Fellow Principal Investigator Process Proteolytic Processing Proteomics RNA RNA-Directed DNA Polymerase Research Research Personnel Resolution Retroviridae Reverse Transcription Role Scientist Students System Techniques Time Training Translating Underrepresented Minority United States National Institutes of Health Utah Viral Virion Virus Virus Assembly broadening participation research combat gag-pol Fusion Proteins human disease male meetings minority scientist next generation novel strategies patient engagement programs symposium therapeutic target virology web site young woman

项目摘要

ABSTRACT During the past decades, the International Retroviral Symposium has focused on identifying key interactions essential for viral assembly and maturation with a particular focus on the nucleocapsid protein and its role. The last meeting of the international retroviral symposium was held in Boston at 2019 where we emphasized the role of NC/Gag in assembly highlighting what has been significant progress in this exciting area. In the 12th International Retroviral Symposium (IRS), we aim to expand the conference focus to include uncoating, and more broadly identify molecular interactions that connect various stages of assembly, maturation and uncoating. The conference has traditionally attracted a group of approximately 100 participants from around the globe. In the 12th IRS, we expect a slightly larger pool of participants, approximately 150, based on the broader focus of the symposium and the long period of time since the 11th symposium held in August 2019. Snowbird Utah provides an idyllic location due to its secluded nature and excellent conference support facility, which maximizes participant engagement. The goal of the 12th IRS is to provide a forum and facilitate identification of fundamental biophysical, biochemical, and virological principles governing retroviruses. These principles will in turn guide development of new antivirals, potent lentiviral systems, and better understanding of the role of retroviruses in human disease, all of which are within the focus of NIH. Our invited speakers are a mix of more junior and established principal investigators, represent countries with active retroviral research and include a significant number of female researchers. The majority of NIH funding will be used to broaden the participation of younger and less represented researchers within the symposium. NIH support is critical for training the next generation as well as injecting new ideas into the field. Conference website: https://ramm2023.utah.edu/

抽象的在过去的几十年里，国际逆转录病毒研讨会一直致力于确定关键的病毒组装和成熟所必需的相互作用，特别关注核衣壳蛋白质及其作用。国际逆转录病毒研讨会的最后一次会议于 2017 年在波士顿举行。 2019 年，我们强调了 NC/Gag 在装配中的作用，强调了重要的内容在这个令人兴奋的领域取得进展。在第 12 届国际逆转录病毒研讨会 (IRS) 中，我们的目标是扩大会议重点包括脱涂层，并更广泛地确定分子相互作用连接组装、熟成和脱衣的各个阶段。传统上，该会议吸引了来自世界各地的约 100 名与会者地球。在第 12 届国税局中，我们预计参与者人数会稍多一些，大约为 150 人，根据自第十一届研讨会以来，本次研讨会的关注点更广泛，时间也更长。 2019 年 8 月。犹他州雪鸟 (Snowbird Utah) 因其僻静的自然环境和卓越的地理位置而提供了一个田园诗般的位置。会议支持设施，最大限度地提高参与者的参与度。第 12 个 IRS 的目标是提供一个论坛并促进基本生物物理学、控制逆转录病毒的生化和病毒学原理。这些原则将反过来指导开发新的抗病毒药物、有效的慢病毒系统以及更好地了解其作用人类疾病中的逆转录病毒，所有这些都属于 NIH 的重点范围。我们邀请的演讲者包括初级研究人员和成熟的主要研究人员，代表逆转录病毒研究活跃的国家，其中包括大量女性研究人员。这 NIH 的大部分资金将用于扩大年轻人和代表性较少的人的参与研讨会上的研究人员。 NIH 的支持对于培训下一代以及为该领域注入新的理念。会议网站：https://ramm2023.utah.edu/