Colorado Clinical and Translational Sciences Institute (CCTSI)

科罗拉多临床与转化科学研究所 (CCTSI)

• 批准号: 10764161
• 负责人: JANINE A HIGGINS
• 金额: $ 772.27万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2030-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10764161
• 关键词: Abbreviations; Acceleration; Address; Adult; Advisory Committees; Applications Grants; Authorization documentation; Biomedical Research; Biometry; COVID-19 pandemic; Center for Translational Science Activities; Child; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Colorado; Communities; Contracts; Data Science; Discipline of Nursing; Diverse Workforce; Education; Effectiveness; Electronic Health Record; Environment; Epidemiology; Equity; Evaluation; Exposure disparity; Faculty; Funding; Funding Opportunities; Future; Goals; Grant; Health; Health Alliance; Health system; Healthcare; Hospitals; Ice; Informatics; Infrastructure; Innovation Corps; Institution; Institutional Review Boards; Jews; Lead; Maps; Maternal and Child Health; Medical; Medical center; Mentored Clinical Scientist Development Program; Mentors; Methodology; Minority Groups; Monitor; Outcomes Research; Patient Care; Pediatric Hospitals; Performance; Pharmacologic Substance; Pharmacy Schools; Play; Process; Program Development; Public Health; Public Health Informatics; Public Health Schools; Reduce health disparities; Research; Research Design; Research Personnel; Research Support; Research Training; Review Committee; Role; Rural Community; Rural Population; Safety; School Dentistry; Science; Site; Special Population; System; TNFSF15 gene; Technology; Time; Training; Training Programs; Translating; Translational Research; Translations; Underserved Population; United States Department of Veterans Affairs; United States National Institutes of Health; Universities; Vision; Workforce Development; authority; career development; clinical translation; collaborative environment; college; community based participatory research; community center; community engagement; community organizations; community partnership; data sharing; design; electronic data; health data; health disparity; health inequalities; improved; innovation; medical schools; minority communities; next generation; pandemic disease; pre-doctoral; process improvement; programs; public health emergency; resilience; response; skills; success; translational impact; translational scientist

PROJECT SUMMARY/ABSTRACT Funded by NIH in 2008, 2013 and 2018, the Colorado Clinical and Translational Sciences Institute (CCTSI) at the University of Colorado Denver (CU Denver) has transformed the clinical and translational research and training enterprise in the Colorado region with the vision of accelerating the translation of discoveries into improved, equitable patient care and public health for all. The CCTSI, headquartered at the CU Anschutz Medical Campus, is a partnership of CU Denver, CU Boulder, Colorado State University (CSU), 5 hospital systems and 20 community organizations, which has advanced translational science by educating a diverse workforce, creating a collaborative environment that supports local and multi-site research, engaging communities through its unique community engagement program, creating methodologies that support research in special populations, and greatly enhancing our informatics and data science capabilities. The CCTSI infrastructure played a critical role in the Colorado response to the COVID pandemic and led to new innovations in research processes and implementation, while recognizing the health inequities and disparities exposed by the pandemic in rural, minority and underserved populations in Colorado. Despite the successes, there remain many challenges to overcoming inefficiencies and roadblocks in clinical translational science (CTS) processes locally and nationally and in reducing health disparities and inequities. This application maps our collaborative path forward to meet these challenges. In the next grant cycle, we will enhance our efforts to improve efficiency and coordination with Partners and across the CTSA Consortium, reinforce our extensive community partnerships, develop innovative informatics and technology solutions to advance CTS, and develop a diverse highly-skilled translational workforce for the future. This UM1 will be tightly coordinated with our other 6 CTSA grant applications, to accomplish the following 6 Overall Strategic Goals: Goal 1: Advance CTS by developing, demonstrating, and disseminating innovative programs to improve the efficiency and impact of translation across the entire T0.5 to T4 spectrum. Goal 2: Promote collaboration, team and data science, and partnerships to accelerate CTS locally, regionally and nationally. Goal 3: Partner locally, regionally and nationally with institutions, stakeholders and communities to develop innovative research programs that will address health inequities and disparities. Goal 4: Further develop operational efficiencies to enhance the quality, safety, efficiency, effectiveness and informativeness of clinical research. Goal 5: Promote a nimble research environment that can rapidly respond to urgent public health needs. Goal 6: Develop and disseminate CTS training programs that educate and sustain a resilient, diverse team of clinical research professionals and investigators. Special efforts will be made to enhance diversity in our workforce. Progress will be monitored and improved by our Evaluation Core and CQI program and we will make mid-course corrections as needed to achieve these goals and ultimately improve the health of our state and the nation.

项目概要/摘要 科罗拉多临床与转化科学研究所 (CCTSI) 于 2008 年、2013 年和 2018 年获得 NIH 资助，位于 科罗拉多大学丹佛分校 (CU Denver) 改变了临床和转化研究 科罗拉多地区的培训企业，其愿景是加速将发现转化为 改善、公平的患者护理和所有人的公共卫生。 CCTSI，总部位于 CU Anschutz Medical Campus 是 CU Denver、CU Boulder、科罗拉多州立大学 (CSU)、5 个医院系统和 20 个社区组织通过教育多元化的劳动力来推进转化科学， 创建一个支持本地和多站点研究的协作环境，通过以下方式吸引社区参与： 其独特的社区参与计划，创建支持特殊研究的方法 人口，并大大提高我们的信息学和数据科学能力。 CCTSI 基础设施 在科罗拉多州应对新冠病毒大流行的过程中发挥了关键作用，并带来了新的研究创新 流程和实施，同时认识到大流行所暴露的健康不平等和差异 科罗拉多州的农村、少数民族和服务不足的人群。尽管取得了成功，但仍有许多 克服临床转化科学 (CTS) 流程中的低效率和障碍的挑战 地方和国家层面以及减少健康差距和不平等。该应用程序映射了我们的 应对这些挑战的合作之路。在下一个资助周期中，我们将加大努力 提高与合作伙伴以及整个 CTSA 联盟的效率和协调，加强我们广泛的 社区伙伴关系，开发创新的信息学和技术解决方案以推进 CTS，并开发 面向未来的多元化高技能翻译队伍。这个 UM1 将与我们的其他 UM1 紧密配合 6 CTSA 拨款申请，以实现以下 6 个总体战略目标： 目标 1：通过以下方式推进 CTS： 制定、展示和传播创新计划，以提高效率和影响力 整个 T0.5 到 T4 频谱的翻译。目标 2：促进协作、团队和数据科学，以及 合作伙伴关系，以加速本地、区域和国家的 CTS。目标 3：在本地、区域和国家范围内开展合作 与机构、利益相关者和社区一起制定解决健康问题的创新研究计划 不平等和差距。目标 4：进一步提高运营效率，以提高质量、安全、 临床研究的效率、有效性和信息量。目标 5：促进灵活的研究 能够快速响应紧急公共卫生需求的环境。目标 6：开发和传播 CTS 培训计划，教育和维持一支有弹性、多元化的临床研究专业人员团队， 调查人员。我们将特别努力增强员工队伍的多样性。将监测进展情况并 通过我们的评估核心和 CQI 计划进行改进，我们将根据需要进行中期修正 实现这些目标并最终改善我们国家和民族的健康。

项目成果

High magnitude exposure to repetitive head impacts alters female adolescent brain activity for lower extremity motor control.

剧烈的重复性头部撞击会改变女性青少年下肢运动控制的大脑活动。

• 发表时间: 2024-04-01
• 影响因子: 2.9
• 作者: Zuleger, Taylor M;Slutsky;Grooms, Dustin R;Yuan, Weihong;Barber Foss, Kim D;Howell, David R;Myer, Gregory D;Diekfuss, Jed A
• 通讯作者: Diekfuss, Jed A