HIV and Substance Use Cohort Coordinating Center for Emerging and High Impact Scientific Cross Cohort Studies: HIV SUCCESS

艾滋病毒和药物使用队列协调中心新兴和高影响科学跨队列研究：艾滋病毒成功

• 批准号: 10676432
• 负责人: GEETANJALI CHANDER
• 金额: $ 93.9万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10676432
• 关键词: Abbreviations; Acceleration; Acquired Immunodeficiency Syndrome; Address; Adherence; Aging; American; Area; Award; Biological Markers; Biological Specimen Banks; Biometry; COVID-19 risk; Caring; Clinical; Clinical Informatics; Code; Cohort Studies; Collaborations; Communities; Complex; Data; Data Analyses; Data Collection; Data Linkages; Data Science; Data Sources; Development; Disparate; Disparity; Dissemination and Implementation; Documentation; Drug usage; Ensure; Epidemic; Epidemiologist; Epidemiology; Evaluation; Funding; Future; Future Generations; Generations; Genetic; HIV; HIV/AIDS; Health; Individual; Infrastructure; Infusion procedures; Intervention; Knowledge; Leadership; Learning; Link; Longitudinal cohort; Mentors; Mentorship; Methamphetamine; Methodology; Molecular Epidemiology; National Institute of Drug Abuse; North America; Opioid; Outcome; Patient Outcomes Assessments; Pattern; Persons; Population; Population Heterogeneity; Positioning Attribute; Prevalence; Provider; Public Health; Public Health Informatics; Publications; Publishing; Regimen; Research; Research Personnel; Research Priority; Resources; Risk; Risk Factors; Running; Rural; Scientist; Site; Statistical Methods; Stimulant; Subgroup; System; Target Populations; Testing; Training; Translations; United States; Work; adjudication; antiretroviral therapy; clinical care; clinical epidemiology; clinical research site; cohort; comorbidity; data harmonization; data integration; data management; data repository; data tools; design; experience; health data; implementation intervention; improved; informatics infrastructure; innovation; method development; multidisciplinary; opioid epidemic; opioid use; pre-exposure prophylaxis; programs; protocol development; social health determinants; spelling; substance use; substance use treatment; syndemic; tool; tool development; transmission process; uptake; web site; working group

The purpose of the HIV and Substance Use Cohort Coordinating Center for Emerging and High Impact Scientific Cross Cohort Studies: HIV SUCCESS is to support National Institute on Drug Abuse funded cohorts as they implement research strategies to better understand and address substance use and its consequences among people with HIV (PWH). Substance use prevalence among PWH is high, and substance use patterns, including increasing concurrent methamphetamine/opioid use as part of the 4th wave of the opioid epidemic, continue to evolve. Substantial challenges remain to improve understanding and implementation of interventions to address substance use and its impacts among PWH. Addressing these challenges is the overarching purpose of the cohorts and requires a coordinating center (CC) experienced in data integration and harmonization, health informatics, multi-site coordination, clinical care and intervention experience, and HIV and substance use research to support the cohorts and comprehensively integrate cross-cohort data. The resulting resource of comprehensively integrated data will give researchers the potential to address important scientific and public health questions that would otherwise not be possible in individual cohorts. We will work with cohorts to allow complex, careful and complete analyses of outcomes and results across diverse populations using harmonized data. We will bring in data from other cohorts and studies as needed to ensure that adequate clinical, biomarker, and/or genetic data are available to address key questions. Careful data harmonization where appropriate will improve the statistical power to identify areas or sub-groups for research focus and to understand what interventions are proving successful in the broader context of the whole population of PWH (as opposed to the target population of a single cohort). This team brings vast experience with HIV cohort data; data linkage and harmonization; methods development; statistical support including causal inference from longitudinal observational data; health informatics platform and tool infrastructure and development including data repositories and tools for efficient and accurate electronically collected patient reported outcomes and outcomes adjudication; providing overall coordination for large collaborations of cohorts and studies; a strong background in clinical epidemiology of HIV and substance use; and expertise in applying this information to clinical care and interventions. We also have a comprehensive mentoring approach to develop a new generation of HIV and substance use researchers. We will support cohorts to enhance data collection where appropriate, merge and harmonize data when feasible, and work together to address key questions on HIV, substance use, and outcomes that cannot be addressed by individual cohorts. By providing project management, mentorship, and support, as well as developing a robust data repository, and accomplishing the integration and linkage of data, we will achieve a multi-disciplinary integrated network with multi-site data with sufficient sizes needed to address substance use and its impacts among PWH.

新兴和高影响力艾滋病毒和药物使用队列协调中心的目的 科学跨队列研究：HIV SUCCESS 将支持国家药物滥用研究所资助的队列 他们实施研究策略以更好地理解和解决药物使用及其后果 艾滋病毒感染者（PWH）。艾滋病毒感染者的药物使用流行率很高，而且药物使用模式、 包括增加甲基苯丙胺/阿片类药物的同时使用，作为第四波阿片类药物流行的一部分， 继续发展。在增进理解和实施方面仍存在重大挑战 解决艾滋病毒感染者的药物使用及其影响的干预措施。应对这些挑战的关键是 队列的总体目标，需要一个在数据集成方面经验丰富的协调中心（CC） 和协调、健康信息学、多站点协调、临床护理和干预经验，以及 HIV 和药物使用研究支持队列并全面整合跨队列数据。这 由此产生的全面整合的数据资源将使研究人员有可能解决重要的问题 科学和公共卫生问题在个别群体中是不可能解决的。我们将工作 与队列一起对不同的结果进行复杂、仔细和完整的分析 使用统一数据的人群。我们将根据需要引入其他队列和研究的数据，以确保 有足够的临床、生物标志物和/或遗传数据来解决关键问题。细心的数据 适当的协调将提高确定研究领域或分组的统计能力 重点关注并了解哪些干预措施在更广泛的整体背景下被证明是成功的 PWH 人群（相对于单个队列的目标人群）。这个团队带来了丰富的经验 HIV 队列数据；数据链接和协调；方法开发；统计支持包括 从纵向观察数据进行因果推断；健康信息学平台和工具基础设施以及 开发包括用于高效、准确地电子收集患者的数据存储库和工具 报告结果和结果裁决；为大型合作提供总体协调 队列和研究；具有艾滋病毒临床流行病学和药物滥用方面的深厚背景；和专业知识 将这些信息应用于临床护理和干预措施。我们还有全面的指导方法 培养新一代艾滋病毒和药物滥用研究人员。我们将支持队列增强数据 在适当的情况下收集数据，在可行的情况下合并和协调数据，并共同解决关键问题 有关艾滋病毒、药物滥用和结果的问题无法由个体群体解决。通过提供 项目管理、指导和支持，以及开发强大的数据存储库，以及 完成数据的整合和联动，实现多学科的综合网络 需要足够规模的多站点数据来解决药物使用及其对艾滋病毒感染者的影响。