A Novel Pediatric Pulsatile Rotary Ventricular Pump

新型儿科脉动旋转心室泵

基本信息

批准号：
7394308
负责人：
DANIEL Edward MAZUR
金额：
$ 12.28万
依托单位：
MC3, INC.
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-02-15 至 2009-02-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7394308
关键词：
1 year old Accidental Injury Acute Address Adult Animals Benchmarking Biomedical Research Blood Blood flow Bos taurus Bypass Cardiac Cardiac Surgery procedures Cardiopulmonary Cardiopulmonary Bypass Cardiovascular system Cattle Cerebrovascular Circulation Cerebrum Characteristics Childhood Clinic Computer Simulation Computers Condition Cost Savings Department of Defense Depth Development Device Safety Devices Electronics Equipment Equipment Failure Failure Fever Figs - dietary Goals Grant Heart Heart Arrest Hemodilution Hemolysis Hour In Vitro Incidence Industry Indwelling Catheter Injury Left Length Liquid substance Literature Marketing Medical Device Modeling Morbidity - disease rate Nature Numbers Operative Surgical Procedures Organ Output Patients Pattern Pediatric Research Pediatric Surgical Procedures Performance Perfusion Phase Physicians Physiological Population Postoperative Period Production Protocols documentation Pulsatile Flow Pump Quality of Care Range Rate Recovery Relative (related person)Reporting Research Research Personnel Resources Rewarming Risk Running Safety Sales Sampling Signal Transduction Simulate Standards of Weights and Measures Stroke Sturnus vulgaris System Techniques Technology Testing Value Meaning Variant Ventricular Work base blood pump career cold temperature comparative cost design desire engineering design experience hemodynamics hyperthermia treatment improved indexing innovation models and simulation natural flow neonate novel older patient pressure prevent prototype research and development success total artificial heart

项目摘要

DESCRIPTION (provided by applicant): A novel Pediatric Pulsatile Rotary Ventricular (PRVP) pump will be researched for pediatric Cardiopulmonary Bypass surgery which offers physiologic pulsatile blood flow, inherently safe management of low extracorporeal volumes, highly accurate very low flow control, and extended durability for long term cardiopulmonary support. These features address ongoing morbidity concerns due to vital organ injury in pediatric CPB patients caused by non-physiologic blood flows, excessive hemodilution, poor cerebral blood flow, and acute injury due to equipment failure and operator error. In addition, the pediatric PRVP presents a new option for pediatric extended cardiac support. The RPVP uses a passively filled compliant pumping chamber and operates under Starling principles, like the natural heart. The compliant pump chamber passively fills, and the pump produces a discharge flow based on the volume of fluid that is provided. A physiologic pulsatile flow is created under constant RPM conditions through a novel lengthwise variation of the pumping chamber geometry. Inherent safety advantages prevent retrograde flow, maintain safe circuit pressures, and prevent inadvertent draining of the venous reservoir. Phase I research will concentrate on designing the novel pump chamber, and validating safety and hydraulic performance on a pediatric mock loop. Computer modeling will be conducted to develop a hydraulic mock loop to simulate a one year old patient model as reported in the literature. The hydraulic mock loop will be manufactured and validated on the bench. The pump design will be tuned through iterative prototyping to generate a physiologic pulsatile flow and pressure in the patient mock loop while operating in a CPB extracorporeal loop configuration. Comparative testing will be conducted in the hydraulic circuit with a standard pulsatile roller pump over a range of flow conditions representative of pediatric CPB and post operative ventricular support. The PRVP design will be bench tested for verification of performance relative to durability and hemolysis. Phase II activities will focus on fabricating preproduction prototypes and conducting animal studies to verify device performance.This grant will result in the development of a novel pediatric blood pump for pediatric Cardiopulmonary Bypass surgery with extended durability to allow for long term cardiac support following surgery. Currently, no pump system of this type exists for pediatric patients so physicians have limited options when cardiac support post surgery is necessary.

描述（由申请人提供）：将研究一种新型儿科脉动旋转心室 (PRVP) 泵，用于儿科心肺旁路手术，该泵提供生理脉动血流、低体外容量的本质安全管理、高精度极低流量控制和延长的耐用性用于长期心肺支持。这些功能解决了儿科 CPB 患者因非生理性血流、过度血液稀释、脑血流不良以及设备故障和操作失误造成的急性损伤导致的重要器官损伤所导致的持续发病率问题。此外，儿科 PRVP 为儿科扩展心脏支持提供了新的选择。 RPVP 使用被动填充的顺应泵室，并按照 Starling 原理运行，就像自然心脏一样。柔性泵室被动填充，并且泵根据所提供的流体体积产生排出流量。通过泵室几何结构的新颖的纵向变化，在恒定的 RPM 条件下产生生理脉动流。固有的安全优势可防止逆流、维持安全回路压力并防止静脉储液器意外排空。第一阶段的研究将集中于设计新颖的泵室，并在儿科模拟回路上验证安全性和液压性能。将进行计算机建模来开发液压模拟回路，以模拟文献中报道的一岁患者模型。液压模拟回路将在工作台上制造和验证。泵设计将通过迭代原型设计进行调整，以在 CPB 体外循环配置中运行时在患者模拟循环中产生生理脉动流量和压力。将在代表儿科 CPB 和术后心室支持的一系列流量条件下，使用标准脉动滚子泵在液压回路中进行比较测试。 PRVP 设计将进行台架测试，以验证与耐用性和溶血相关的性能。第二阶段的活动将侧重于制造预生产原型并进行动物研究以验证设备性能。这笔赠款将导致开发一种用于儿科心肺搭桥手术的新型儿科血泵，该泵具有更长的耐用性，以便在手术后提供长期心脏支持。目前，还没有适用于儿科患者的这种类型的泵系统，因此当术后需要心脏支持时，医生的选择有限。

项目成果

期刊论文数量（2）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

A novel rotary pulsatile flow pump for cardiopulmonary bypass.

一种用于体外循环的新型旋转脉动流泵。

DOI：
发表时间：
2014-05
期刊：
影响因子：
0
作者：
Teman, Nicholas R;Mazur, Daniel E;Toomasian, John;Jahangir, Emilia;Alghanem, Fares;Goudie, Marcus;Rojas;Haft, Jonathan W
通讯作者：
Haft, Jonathan W

A novel, low cost, disposable, pediatric pulsatile rotary ventricular pump for cardiac surgery that provides a physiological flow pattern.

一种新型、低成本、一次性儿科脉动旋转心室泵，用于心脏手术，提供生理流动模式。