Effect of Prenatal DHA Supplements on Infant Development

产前 DHA 补充剂对婴儿发育的影响

• 批准号: 7735889
• 负责人: USHA RAMAKRISHNAN
• 金额: $ 51.13万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-16 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7735889
• 关键词: 5 year old; Acids; Address; Adverse effects; Age; Area; Asthma; Attention; Behavior assessment; Birth; Child; Child Development; Child health care; Cognitive; Cohort Studies; Collaborations; Data; Development; Dietary intake; Docosahexaenoic Acids; Double-Blind Method; Exposure to; Fishes; Funding; Grant; Growth and Development function; Head circumference; Health; Health Status; Heavy Metals; High birth weight infant; Home environment; Human; Hypersensitivity; Infant Development; Institutes; Life; Light; Link; Live Birth; Measurement; Measures; Memory; Mercury; Mexican; Mexico; Mothers; Motor; N-3 polyunsaturated fatty acid; Parents; Performance; Pesticides; Placebos; Policies; Polyunsaturated Fatty Acids; Population Study; Positioning Attribute; Pregnancy; Pregnant Women; Principal Investigator; Process; Protocols documentation; Public Health; Randomized; Randomized Controlled Trials; Readiness; Recommendation; Recruitment Activity; Role; Schools; Science; Seafood; Source; Supplementation; Technology; Time; Training; Umbilical Cord Blood; Universities; Update; Visit; Woman; cognitive function; cohort; early childhood; executive function; experience; first grade; follow-up; improved; instrument; interest; kindergarten; member; mental development; offspring; prenatal; primary outcome; public health relevance

DESCRIPTION (provided by principal investigator): This competing renewal builds on successful completion of a double blind randomized controlled trial (RCT) of DHA supplementation during pregnancy in Cuernavaca, Mexico, and is a collaborative effort between the Hubert Department of Global Health, Emory University in Atlanta GA and the National Institute of Public Health (INSP) in Cuernavaca, Mexico. The overall objective is to extend to age 5 y our examination of the effects on the offspring of maternal supplementation during pregnancy with docosahexaenoic acid (DHA). Our central hypothesis is that DHA supplementation during pregnancy will improve early childhood development. In the original trial, 1094 pregnant women were randomized to receive daily a supplement of 400 mg of DHA or a placebo from 18-22 weeks of pregnancy. The 973 live births are currently being followed up to age 18 mos for measures of growth and development. We propose to study the birth cohort at age 5 y. We plan to collect a comprehensive set of measures of early childhood development (ECD) that are known to predict later intellectual functioning. The primary outcomes include global motor and mental development, executive functioning, specifically attention and memory, and inhibitory processes. Additional data on dietary intakes, health and exposure to early childhood stimulation both at the home and outside will also be obtained. All measurements will be obtained by a well trained and experienced field team; many team members participated in the parent study and have developed good rapport with the study population. We expect to recruit at least 85 percent of the eligible birth cohort and will have adequate power to detect effect sizes of 0.3 S.D. We will link these new data to our extraordinarily rich array of data that we collected prenatally, at birth, and at ages 1, 3, 6, 9, 12 and 18 mos. In addition to analyses that focus on the overall impact of supplementation with DHA, we will explore hypotheses concerning developmental trajectories. These data will also position us to continue to follow this cohort during their early school years. PUBLIC HEALTH RELEVANCE: The objective of this competing renewal of grant HD43099 is to continue our examination of the effects of docosahexanoic acid (DHA) during pregnancy on child development at 5 years of age. This project builds on our successful completion of a large double blind randomized controlled trial of prenatal DHA supplementation in Cuernavaca, Mexico; we propose to resurvey the birth cohort (973 live births) at 4 years to maintain contact and at 5 years to obtain on a comprehensive set of measures of early childhood development (ECD). This renewal will strengthen our ongoing collaboration between Emory and National Institute of Public Health in Cuernavaca, Mexico and will provide the scientific evidence for making appropriate dietary recommendations for DHA during pregnancy to enhance human health and performance, especially educability.

描述（由首席研究员提供）：这种竞争性更新是在墨西哥库尔纳瓦卡怀孕期间成功完成DHA补充双重盲随机对照试验（RCT）的基础，并且是Hubert全球健康系亚特兰大大学Emory University的Hubert全球健康系与公共健康研究所（National Health of Public Health）的合作努力（cuernavaca）。总体目标是扩展到5岁，我们检查对二十六烯酸（DHA）怀孕期间孕产妇补充后代的影响。我们的中心假设是，怀孕期间补充DHA将改善幼儿发展。在最初的试验中，将1094名孕妇随机分配，每天接受400毫克DHA或安慰剂的补充，从怀孕18-22周。目前，有973个活产的直到18岁的MOS进行了生长和发展的措施。我们建议研究5年龄的出生队列。我们计划收集一系列幼儿发展（ECD）的综合度量，这些度量可以预测以后的智力功能。主要结果包括全球运动和心理发展，执行功能，特别是注意力和记忆以及抑制过程。还将获得有关饮食摄入量，健康摄入量和对幼儿刺激的其他数据。所有测量都将由训练有素且经验丰富的现场团队获得；许多团队成员参加了家长研究，并与研究人群建立了良好的融洽关系。我们预计将招募至少85％的符合条件的出生队列，并具有足够的能力来检测0.3 s.d的效应大小。我们将将这些新数据与我们在产前，出生时以及1，3、6、9、9、12和18 MOS时收集的非常丰富的数据联系起来。除了侧重于补充DHA的总体影响的分析外，我们还将探讨有关发育轨迹的假设。这些数据还将使我们在早期学年继续遵循这一队列。公共卫生相关性：授予HD43099的这种竞争续约的目的是继续我们对怀孕期间5岁儿童发育过程中二十六己酸（DHA）的影响进行检查。该项目基于我们成功完成了墨西哥Cuernavaca的大型双盲随机对照试验；我们建议在4年时重新恢复出生队列（973个活产），以维持接触，并在5年以后获得一套全面的幼儿发展措施（ECD）。这种更新将加强我们在墨西哥库尔纳瓦卡的埃默里和国家公共卫生研究所之间的持续合作，并将提供科学证据，以在怀孕期间为DHA提出适当的饮食建议，以增强人类健康和绩效，尤其是可教育性。