Effect of prenatal DHA supplements on infant development
产前补充 DHA 对婴儿发育的影响
基本信息
- 批准号:7009998
- 负责人:
- 金额:$ 58.54万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2004
- 资助国家:美国
- 起止时间:2004-04-16 至 2008-01-31
- 项目状态:已结题
- 来源:
- 关键词:child physical developmentclinical researchcord bloodcyclic aciddevelopmental neurobiologydiet therapydietary supplementsevoked potentialsgestational agegrowth /developmenthuman subjecthuman therapy evaluationinfant human (0-1 year)nutrition related tagpatient oriented researchpregnancyprenatal caresocioeconomicsunsaturated fatty acids
项目摘要
DESCRIPTION (provided by applicant): Our research is about the significance of polyunsaturated fatty acids (PUFAs) for human development. Specifically, we will assess the effect of docasohexanoic acid (DHA) supplementation during pregnancy on infant growth and development through a randomized controlled intervention trial in Cuernavaca, Mexico. This will be a collaborative effort among the Department of International Health, Rollins School of Public Health, Emory University, the Instituto Nacional de Salud Publica (INSP) and the Instituto Mexicano del Seguro Social (IMSS), Cuernavaca, Mexico. Pregnant women (n=994) attending the IMSS General Hospital I will be recruited at 20-24 wks gestation and assigned randomly to receive either DHA (200 mg) or a placebo daily until delivery. The main study endpoints include a) birth outcomes: birth size, gestational age, cord blood levels of DHA and neurodevelopment, b) maternal blood and breast milk DHA levels at 1 and 3 mo post-partum), c) postnatal growth and development during the first 18 mo of age and d) infant DHA status at 3, 12 and 18 mo. All data collection will be carried out at the study headquarters (IMSS) except for home environment that will be assessed during home visits at 6 and 12 mo. Physical growth (length, weight, and head circumference) and infant development (Brazelton & Fagan test, visual and auditory evoked potentials, and Bayley scales of infant development) will be measured at birth, 1, 3, 6, 9, 12 and 18 mo by trained nurses and psychologists, respectively. Data will also be obtained on socioeconomic status, obstetric history, maternal diet, anthropometry and intelligence, quality of home environment and infant feeding practices. Data analyses will include group comparisons (intent-to-treat) after ensuring effectiveness of randomization, and structural equation modeling to examine the various pathways by which DHA supplementation during pregnancy affects child growth and development. The findings of this project will contribute significantly to our understanding of the functional consequences of DHA supplementation during pregnancy.
描述(由申请人提供):我们的研究是关于多不饱和脂肪酸(PUFAS)对人类发育的重要性。具体而言,我们将通过在墨西哥Cuernavaca进行的随机对照干预试验来评估妊娠期间docasohexanoic Acid(DHA)补充对婴儿生长和发育的影响。这将是国际卫生部,罗林斯公共卫生学院,埃默里大学,埃默里大学,INSP)和墨西哥Cuernavaca的墨西哥墨西哥人社会(IMSSS)的合作努力。 孕妇(n = 994)将在IMSS综合医院就读I将在20-24周妊娠招募,并随机分配以每天接受DHA(200 mg)或安慰剂,直到分娩为止。 主要研究终点包括a)出生结果:出生大小,胎龄,DHA和神经发育的脐带血水平,b)产后1和3 mo的母亲血液和母乳DHA水平),C)在第3、12和18 mo处的前18 mo和DHA状态的前18 mo和DHA状态的产后生长和发育。所有数据收集将在研究总部(IMS)进行,除了家庭访问期间6和12月期间评估的家庭环境。身体生长(长度,体重和头围)和婴儿发育(Brazelton&Fagan测试,视觉和听觉诱发的潜力以及婴儿发育的Bayley量表)将分别通过训练有素的护士和心理学家在出生时测量1、3、6、9、9、12和18 MO。还将获得有关社会经济状况,产科历史,孕产妇饮食,人体测量和智力,家庭环境质量和婴儿喂养实践的数据。数据分析将包括在确保随机效率和结构方程建模后的组比较(意图对治疗),以检查怀孕期间补充DHA会影响儿童成长和发育的各种途径。该项目的发现将极大地有助于我们理解怀孕期间补充DHA的功能后果。
项目成果
期刊论文数量(0)
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会议论文数量(0)
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USHA RAMAKRISHNAN其他文献
USHA RAMAKRISHNAN的其他文献
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{{ truncateString('USHA RAMAKRISHNAN', 18)}}的其他基金
Effect of Prenatal DHA Supplements on Infant Development
产前 DHA 补充剂对婴儿发育的影响
- 批准号:
8305032 - 财政年份:2004
- 资助金额:
$ 58.54万 - 项目类别:
Effect of Prenatal DHA Supplements on Infant Development
产前 DHA 补充剂对婴儿发育的影响
- 批准号:
7735889 - 财政年份:2004
- 资助金额:
$ 58.54万 - 项目类别:
Effect of Prenatal DHA Supplements on Infant Development
产前 DHA 补充剂对婴儿发育的影响
- 批准号:
7933673 - 财政年份:2004
- 资助金额:
$ 58.54万 - 项目类别:
Effect of prenatal DHA supplements on infant development
产前补充 DHA 对婴儿发育的影响
- 批准号:
6886819 - 财政年份:2004
- 资助金额:
$ 58.54万 - 项目类别:
Effect of prenatal DHA supplements on infant development
产前补充 DHA 对婴儿发育的影响
- 批准号:
7183613 - 财政年份:2004
- 资助金额:
$ 58.54万 - 项目类别:
Effect of prenatal DHA supplements on infant development
产前补充 DHA 对婴儿发育的影响
- 批准号:
6772920 - 财政年份:2004
- 资助金额:
$ 58.54万 - 项目类别:
Effect of Prenatal DHA Supplements on Infant Development
产前 DHA 补充剂对婴儿发育的影响
- 批准号:
8122407 - 财政年份:2004
- 资助金额:
$ 58.54万 - 项目类别:
DHA in Pregnancy and Immune Function in Mexican Infants
DHA 在妊娠期和墨西哥婴儿免疫功能中的作用
- 批准号:
6967372 - 财政年份:2002
- 资助金额:
$ 58.54万 - 项目类别:
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