Partnership for advancing cervical cancer prevention in women living with HIV (CASCADE - Research Hub)

促进艾滋病毒感染女性宫颈癌预防的伙伴关系（CASCADE - 研究中心）

基本信息

批准号：
10707249
负责人：
Carla J Chibwesha
金额：
$ 65.01万
依托单位：
WEILL MEDICAL COLL OF CORNELL UNIV
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-20 至 2027-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10707249
关键词：
AIDS Malignancy Consortium AIDS clinical trial group Adherence Adoption Affect Aftercare Area Cancer Prevention Trial Cervical Cervical Cancer Screening Characteristics Clinic Clinical Clinical Research Clinical Trials Cold Therapy Collaborations Colposcopy Communication Consolidated Framework for Implementation Research Data Decision Making Detection Development Division of Cancer Prevention Effectiveness Fluorouracil Fostering Frequencies Future Goals HIV HPV-High Risk Human Papilloma Virus-Related Malignant Neoplasm Human Papillomavirus Individual Infrastructure Institution International Intervention Investigation Leadership Maintenance Malignant neoplasm of cervix uteri Mentors Patients Performance Persons Physicians Positioning Attribute Pragmatic clinical trial Prevention trial Primary Care Process Recording of previous events Research Research Personnel Resource-limited setting Sampling Sensitivity and Specificity Site Specimen Squamous intraepithelial lesion Testing Treatment outcome Triage Visual Woman Work antiretroviral therapy automated visual evaluation base career career development cervical cancer prevention clinical care clinical research site community engagement cost design effectiveness evaluation effectiveness outcome experience implementation evaluation implementation outcomes implementation science improved improved outcome loop electrosurgical excision procedure low and middle-income countries member point of care pragmatic trial premalignant prevention service protocol development randomized, clinical trials repository scale up screening screening services skills standard of care treatment trial uptake

项目摘要

PROJECT ABSTRACT The overarching goal of the “Partnership for Advancing Cervical Cancer Prevention in Women Living with HIV” is to improve the cascade of cervical cancer prevention for women living with HIV (WLWH) including increasing uptake of cervical cancer screening services, improving management of screen positive women, and optimizing precancer treatment outcomes, particularly in resource-constrained settings. Research base members have established collaborations with a history of conducting successful clinical trials and impacting clinical care. As a CASCADE Research Base, we will provide impactful scientific and statistical direction for pragmatic clinical trials to be conducted at the CASCADE Clinical Sites. We will establish a central administrative infrastructure to facilitate the conduct of three pragmatic trials. The proposed trials will include an investigation of primary HPV screening to facilitate uptake of cervical cancer screening, triage strategies for women who screen positive with high-risk HPV, and adjunctive treatment to improve outcomes to cervical pre-cancer treatments. We will also provide opportunities for early-stage investigators to develop clinical research skills within CASCADE. We have administrative expertise and experience in operationalizing international clinical trials and supporting clinical research sites in the timely implementation of projects. Our highly experienced investigators and our proposed trials will be of substantial benefit to the CASCADE network and the shared goal of eliminating cervical cancer in WLWH.

项目摘要 “在艾滋病毒妇女中预防宫颈癌预防的伙伴关系”的总体目标是是为了改善艾滋病毒（WLWH）女性的宫颈癌预防级联宫颈癌筛查服务的吸收，改善屏幕正面女性的管理以及优化预科治疗结果，特别是在资源约束的设置中。研究基础成员有建立了与进行成功的临床试验并影响临床护理的历史的合作。作为级联研究基础，我们将为实用临床试验提供有影响力的科学和统计方向在级联临床部位进行。我们将建立一个中央行政基础设施，以促进三项务实试验的行为。拟议的试验将包括对主要HPV筛查的投资，以促进宫颈癌的摄取筛查，针对高风险HPV筛选阳性的女性的分类策略以及辅助治疗改善宫颈前治疗的结果。我们还将为早期提供机会调查人员在级联中发展临床研究技能。我们在运营国际临床试验和支持方面拥有行政专业知识和经验及时实施项目中的临床研究站点。我们经验丰富的调查员和我们的拟议的试验将对级联网络有很大的好处，并且取消颈椎的共同目标 WLWH的癌症。