Patient Oriented Research In Clinical Nutrition
以患者为中心的临床营养研究
基本信息
- 批准号:8384510
- 负责人:
- 金额:$ 17.75万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-07-16 至 2017-06-30
- 项目状态:已结题
- 来源:
- 关键词:AreaBioinformaticsBiological MarkersClinicalClinical InvestigatorClinical NutritionClinical ResearchClinical SciencesCommitCritical CareCritical IllnessCystic FibrosisDevelopmentDietDietary InterventionDisciplineDiscipline of NursingDoctor of PhilosophyDoseFacultyFemaleFoundationsFundingFunding ApplicantGenerationsGlutamineGoalsGrantHealth SciencesIndustryInstitutesInternationalJournalsJunior PhysicianLeadershipLinkMedicalMedical StudentsMedicineMentorsMetabolicMetabolismMethodsMid-Career Clinical Scientist Award (K24)Midcareer Investigator Award in Patient-Oriented ResearchMinority GroupsMolecularNutrition AssessmentNutritionalNutritional StudyOperative Surgical ProceduresOutcomeOxidation-ReductionPatientsPediatricsPhysiciansPlasmaPostdoctoral FellowProductivityPublicationsPulmonary TuberculosisRecording of previous eventsResearchResearch ActivityResearch DesignResearch InstituteResearch PersonnelResearch TrainingResourcesRoleSamplingScienceServicesShort Bowel SyndromeSickle Cell AnemiaSocietiesSourceSpecialistStudy SectionTherapeuticTimeTrainingTraining and EducationTranslational ResearchUnited States National Institutes of HealthVitamin DWagesWestern Asia Georgiacareer developmenteditorialethnic minority populationglobal healthgraduate studentinnovationinvestigator trainingmembermetabolomicsmultidisciplinarynovelnutritionpatient orientedpatient oriented researchpatient populationpost-doctoral trainingpre-doctoralprofessorprogramsskillstoolundergraduate student
项目摘要
DESCRIPTION (provided by applicant): This competing renewal application for the Midcareer Investigator Award in Patient Oriented Research (K24) "Patient-Oriented Research in Clinical Nutrition" seeks support for an accomplished physician nutrition specialist and established investigator in clinical and translational nutrition science. The P.I. remains highly committed to performing patient-oriented research (POR), focused on nutrition, and in mentoring undergraduates, graduate and medical students, postdoctoral fellows, clinical residents, and junior faculty in clinical nutrition research to continue to develop a needed new cadre of well-trained investigators in Clinical Nutrition. Renewal of this proposal will provide protected time t enable the P.I. to continue to advance his research and mentoring efforts in nutrition-oriented research, and provide additional training and resources in state-of-the-art metabolomics methods that will in turn enhance his ability to mentor physicians and other clinical investigators
in nutrition-related studies. The applicant has a unique training background in nutrition and medicine and an excellent record of federal, foundation and industry funding for his investigator-initiated POR and translational research. He maintains a strong and growing publication record, renewed independent funding for POR from NIH and other sources, a continued history of leadership roles in national nutrition- related societies, and increasing service on the editorial boards of front-line nutrition-oriented research journals. At Emory, the P.I. serves in the leadership of the NIH-funded CTSA grant, the Atlanta Clinical and Translational Science Institute (ACTSI), including as Co-Program Director of the ACTSI Research Education, Training and Career Development (RETCD) program, Co-Program Director of the ACTSI/RETCD KL2 postdoctoral training grant, and Program Director of the ACTSI/RETCD TL1 predoctoral training grant (TL1 RR025010). He serves in leadership roles with the Center for Clinical and Molecular Nutrition, several T32 training grants and the Emory graduate program in Nutrition and Health Science - all of which provide opportunities for continued mentoring in POR. Since the initial funding of this K24 grant (07/01/07), the P.I. has mentored the clinical/translational research activities of 32 trainees, from the level of undergraduate student to junior faculty, including a current cadre of 3 physician junior faculty members from the Emory Departments of Medicine and Pediatrics, respectively; 2 Ph.D. junior faculty investigators; 4 international physician investigators from the former Soviet Republic of Georgia; 3 physician postdoctoral fellows; 4 Ph.D.-trained postdoctoral fellows; a Pharm.D. specialist in clinical nutrition support; 3 Emory Ph.D. graduate students (2 in Nutrition and Health Sciences and 1 in Nursing) and an Emory undergraduate student. The candidate's POR program provides a rich training substrate for current and potential mentees and includes ACTSI-leveraged studies on the efficacy and metabolic impact of glutamine in catabolic states, including critical care, short bowel syndrome, cystic fibrosis. sickle cell anemia, diet-related redox control and metabolomics analysis.
PUBLIC HEALTH RELEVANCE: There is a national need to train new investigators, including physicians, in nutrition-oriented clinical research. The candidate for this K24 grant renewal has a
well-established track record of research publications, NIH and other funding, and leadership roles and mentoring in patient-oriented clinical nutrition research. Renewal of his K24 grant will provide the protected time and resources to allow the applicant to continue to grow his cadre of multidisciplinary mentees in this area, and to further develop the novel research area of nutritional metabolomics as a tool for biomarker discovery, nutritional assessment and outcome prediction.
描述(由申请人提供):这项以患者为导向的研究(K24)“以患者为导向的临床营养研究”中的职业生涯中期调查员奖的竞争性续展申请寻求对一位有成就的医师营养专家和临床和转化营养科学领域知名调查员的支持。 P.I.仍然高度致力于开展以患者为中心的研究(POR),重点关注营养,并指导临床营养研究领域的本科生、研究生和医学生、博士后研究员、临床住院医师和初级教师,以继续培养所需的新骨干队伍-经过培训的临床营养研究人员。更新该提案将为 P.I. 提供受保护的时间。继续推进他在营养导向研究方面的研究和指导工作,并提供最先进的代谢组学方法的额外培训和资源,从而增强他指导医生和其他临床研究人员的能力
在营养相关的研究中。申请人在营养和医学方面拥有独特的培训背景,并在其研究者发起的 POR 和转化研究中获得联邦、基金会和行业资助的良好记录。他保持着强劲且不断增长的发表记录,从 NIH 和其他来源为 POR 提供了新的独立资助,在国家营养相关学会中持续担任领导角色,并在一线营养导向研究期刊的编辑委员会中提供越来越多的服务。在埃默里大学,P.I.领导 NIH 资助的 CTSA 资助的亚特兰大临床和转化科学研究所 (ACTSI),包括担任 ACTSI 研究教育、培训和职业发展 (RETCD) 项目的联合项目主任、 ACTSI/RETCD KL2 博士后培训补助金,以及 ACTSI/RETCD TL1 博士前培训补助金 (TL1 RR025010) 的项目总监。他在临床和分子营养中心、多项 T32 培训补助金和埃默里大学营养与健康科学研究生项目中担任领导职务,所有这些都为 POR 方面的持续指导提供了机会。自这项 K24 拨款的初始资助(2007 年 7 月 1 日)以来,P.I.指导了 32 名从本科生到初级教员的学员的临床/转化研究活动,其中包括目前分别来自埃默里大学医学系和儿科系的 3 名初级医师教员; 2 博士初级教师调查员; 4名来自前苏联格鲁吉亚共和国的国际医师调查员;医师博士后3名;博士培养博士后4名;药学博士临床营养支持专家; 3 埃默里大学博士研究生(2 名营养与健康科学专业和 1 名护理专业)和埃默里大学本科生。候选人的 POR 计划为当前和潜在的学员提供了丰富的培训基础,包括利用 ACTSI 进行的研究,研究谷氨酰胺在分解代谢状态下的功效和代谢影响,包括重症监护、短肠综合征、囊性纤维化。镰状细胞性贫血、饮食相关的氧化还原控制和代谢组学分析。
公共卫生相关性:国家需要培训新的研究人员,包括医生,进行以营养为导向的临床研究。此次 K24 补助金续展的候选人有
在研究出版物、NIH 和其他资金以及以患者为导向的临床营养研究中的领导作用和指导方面拥有良好的记录。续订 K24 补助金将提供受保护的时间和资源,使申请人能够继续发展该领域的多学科受训者骨干队伍,并进一步开发营养代谢组学的新研究领域,作为生物标志物发现、营养评估和研究的工具。结果预测。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Thomas R Ziegler其他文献
Thomas R Ziegler的其他文献
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{{ truncateString('Thomas R Ziegler', 18)}}的其他基金
Patient Oriented Research In Clinical Nutrition
以患者为中心的临床营养研究
- 批准号:
8692755 - 财政年份:2012
- 资助金额:
$ 17.75万 - 项目类别:
Patient Oriented Research In Clinical Nutrition
以患者为中心的临床营养研究
- 批准号:
9103104 - 财政年份:2012
- 资助金额:
$ 17.75万 - 项目类别:
Patient Oriented Research In Clinical Nutrition
以患者为中心的临床营养研究
- 批准号:
8511625 - 财政年份:2012
- 资助金额:
$ 17.75万 - 项目类别:
Comparative effectiveness of energy dose in critical illness
能量剂量在危重疾病中的比较效果
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8294603 - 财政年份:2011
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$ 17.75万 - 项目类别:
Comparative effectiveness of energy dose in critical illness
能量剂量在危重疾病中的比较效果
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8114637 - 财政年份:2011
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$ 17.75万 - 项目类别:
Efficacy and Mechanisms of GLN Dipeptide in the SICU
GLN二肽在SICU中的疗效及机制
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7908371 - 财政年份:2009
- 资助金额:
$ 17.75万 - 项目类别:
Patient Oriented Research in Clinical Nutrition
以患者为中心的临床营养研究
- 批准号:
8113332 - 财政年份:2007
- 资助金额:
$ 17.75万 - 项目类别:
Patient Oriented Research in Clinical Nutrition
以患者为中心的临床营养研究
- 批准号:
7185258 - 财政年份:2007
- 资助金额:
$ 17.75万 - 项目类别:
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